M. A. Whitehead
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View article: CRISPRa-Mediated Increase of OPA1 Expression in Dominant Optic Atrophy
CRISPRa-Mediated Increase of OPA1 Expression in Dominant Optic Atrophy Open
Dominant Optic Atrophy (DOA) is the most common inherited optic neuropathy and presents as gradual visual loss caused by the loss of retinal ganglion cells (RGCs). Over 60% of DOA cases are caused by pathogenic variants in the OPA1 gene, w…
View article: Disruption of mitochondrial homeostasis and permeability transition pore opening in OPA1 iPSC-derived retinal ganglion cells
Disruption of mitochondrial homeostasis and permeability transition pore opening in OPA1 iPSC-derived retinal ganglion cells Open
Dominant optic atrophy (DOA) is the most common inherited optic neuropathy, characterised by the selective loss of retinal ganglion cells (RGCs). Over 60% of DOA cases are caused by pathogenic variants in the OPA1 gene, which encodes a dyn…
View article: Disruption of mitochondrial homeostasis and permeability transition pore opening in OPA1 iPSC-derived retinal ganglion cells
Disruption of mitochondrial homeostasis and permeability transition pore opening in OPA1 iPSC-derived retinal ganglion cells Open
Dominant optic atrophy (DOA) is the most common inherited optic neuropathy, characterised by the selective loss of retinal ganglion cells (RGCs). Over 60% of DOA cases are caused by pathogenic variants in the OPA1 gene, which encodes a dyn…
View article: Real time measurement of shock pressure
Real time measurement of shock pressure Open
A fiber-based optical pressure-sensor, made using semiconductor nanocrystal quantum dots (NQDs) as the active transducing material, provides response time fast enough for shock wave measurements. For NQDs, the shift in band gap as a result…
View article: Immunobiology of a rationally-designed AAV2 capsid following intravitreal delivery in mice
Immunobiology of a rationally-designed AAV2 capsid following intravitreal delivery in mice Open
Adeno-associated virus serotype 2 (AAV2) is a viral vector that can be used to deliver therapeutic genes to diseased cells in the retina. One strategy for altering AAV2 vectors involves the mutation of phosphodegron residues, which are tho…
View article: Humoral immune responses to <scp>AAV</scp> gene therapy in the ocular compartment
Humoral immune responses to <span>AAV</span> gene therapy in the ocular compartment Open
Viral vectors can be utilised to deliver therapeutic genes to diseased cells. Adeno‐associated virus (AAV) is a commonly used viral vector that is favoured for its ability to infect a wide range of tissues whilst displaying limited toxicit…
View article: Angiopoietins in Diabetic Retinopathy: Current Understanding and Therapeutic Potential
Angiopoietins in Diabetic Retinopathy: Current Understanding and Therapeutic Potential Open
Diabetic retinopathy (DR) is the commonest cause of blindness in the working-age population of the developed world. The molecular pathophysiology of DR is complex, and a complete spatiotemporal model of the disease is still being elucidate…
View article: Diabetic retinopathy: a complex pathophysiology requiring novel therapeutic strategies
Diabetic retinopathy: a complex pathophysiology requiring novel therapeutic strategies Open
INTRODUCTION: Diabetic retinopathy (DR) is the leading cause of vision loss in the working age population of the developed world. DR encompasses a complex pathology, and one that is reflected in the variety of currently available treatment…