Michael Wiest
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View article: Conscious active inference II: quantum orchestrated objective reduction among intraneuronal microtubules naturally accounts for discrete perceptual cycles
Conscious active inference II: quantum orchestrated objective reduction among intraneuronal microtubules naturally accounts for discrete perceptual cycles Open
View article: Old theory, new evidence: inhalational anesthetics disrupt a collective quantum state of intraneuronal microtubules to cause unconsciousness
Old theory, new evidence: inhalational anesthetics disrupt a collective quantum state of intraneuronal microtubules to cause unconsciousness Open
View article: AI discovery of TLR agonist-driven phenotypes reveals unique features of peripheral cells from healthy donors and ART-suppressed people living with HIV
AI discovery of TLR agonist-driven phenotypes reveals unique features of peripheral cells from healthy donors and ART-suppressed people living with HIV Open
Background Selective and potent Toll-like receptor (TLR) agonists are currently under evaluation in preclinical models and clinical studies to understand how the innate immune system can be harnessed for therapeutic potential. These molecu…
View article: Conscious active inference I: A quantum model naturally implements the path integral needed for real-time planning and control
Conscious active inference I: A quantum model naturally implements the path integral needed for real-time planning and control Open
View article: Corrigendum to “Conscious active inference II: Quantum orchestrated objective reduction among intraneuronal microtubules naturally accounts for discrete perceptual cycles” [Comput Struct Biotechnol J 30 (2024) 3314]
Corrigendum to “Conscious active inference II: Quantum orchestrated objective reduction among intraneuronal microtubules naturally accounts for discrete perceptual cycles” [Comput Struct Biotechnol J 30 (2024) 3314] Open
[This corrects the article DOI: 10.1016/j.csbj.2025.09.016.].
View article: A quantum microtubule substrate of consciousness is experimentally supported and solves the binding and epiphenomenalism problems
A quantum microtubule substrate of consciousness is experimentally supported and solves the binding and epiphenomenalism problems Open
Recent experimental evidence, briefly reviewed here, points to intraneuronal microtubules as a functional target of inhalational anesthetics. This finding is consistent with the general hypothesis that the biophysical substrate of consciou…
View article: Morphological map of under- and over-expression of genes in human cells
Morphological map of under- and over-expression of genes in human cells Open
Cell Painting images offer valuable insights into a cell’s state and enable many biological applications, but publicly available arrayed datasets only include hundreds of genes perturbed. The JUMP (Joint Undertaking in Morphological Profil…
View article: A combined AI and cell biology approach surfaces targets and mechanistically distinct Inflammasome inhibitors
A combined AI and cell biology approach surfaces targets and mechanistically distinct Inflammasome inhibitors Open
Inflammasomes are protein complexes that mediate innate immune responses whose dysregulation has been linked to a spectrum of acute and chronic human conditions, which dictates therapeutic development that is aligned with disease variabili…
View article: Using beam polarization to study anomalous electroweak physics and supersymmetry
Using beam polarization to study anomalous electroweak physics and supersymmetry Open
View article: A Combinatorial AI and Cell Biology Approach Identifies Mechanistically Distinct Inflammasome Inhibitors and Implicates the Raf Pathway in Inflammasome Signaling
A Combinatorial AI and Cell Biology Approach Identifies Mechanistically Distinct Inflammasome Inhibitors and Implicates the Raf Pathway in Inflammasome Signaling Open
View article: Optical design, analysis, and performances of the infrared and visible channels of the warm calibration unit in METIS/ELT
Optical design, analysis, and performances of the infrared and visible channels of the warm calibration unit in METIS/ELT Open
METIS, the mid-infrared imager and spectrograph for the wavelength range 2.9 -13.5 µm (astronomical L-, MN- band), will be one of the three science instruments at the Extremely Large Telescope (ELT). It will provide diffraction-limited ima…
View article: Warm calibration unit of the mid-infrared E-ELT instrument METIS: overview and current status of the project
Warm calibration unit of the mid-infrared E-ELT instrument METIS: overview and current status of the project Open
The warm calibration unit (WCU) is one subsystem of the future METIS instrument on the European Extremely Large Telescope (E-ELT). Operating at daytime temperature, the WCU is mounted above the main cryostat of METIS and will be employed a…
View article: The GRAVITY young stellar object survey
The GRAVITY young stellar object survey Open
Context. 51 Oph is a Herbig Ae/Be star that exhibits strong near-infrared CO ro-vibrational emission at 2.3 μ m, most likely originating in the innermost regions of a circumstellar disc. Aims. We aim to obtain the physical and geometrical …
View article: The GRAVITY Young Stellar Object survey IV. The CO overtone emission in\n 51 Oph at sub-au scales
The GRAVITY Young Stellar Object survey IV. The CO overtone emission in\n 51 Oph at sub-au scales Open
51 Oph is a Herbig Ae/Be star that exhibits strong near-infrared CO\nro-vibrational emission at 2.3 micron, most likely originating in the innermost\nregions of a circumstellar disc. We aim to obtain the physical and geometrical\npropertie…
View article: The GRAVITY young stellar object survey: III. The dusty disk of RY Lup
The GRAVITY young stellar object survey: III. The dusty disk of RY Lup Open
Context. Studies of the dust distribution, composition, and evolution of protoplanetary disks provide clues for understanding planet formation. However, little is known about the innermost regions of disks where telluric planets are expect…
View article: Evoked Frontal and Parietal Field Potential Signatures of Target Detection and Response Inhibition in Rats Performing an Equiprobable Auditory Go/No-Go Task
Evoked Frontal and Parietal Field Potential Signatures of Target Detection and Response Inhibition in Rats Performing an Equiprobable Auditory Go/No-Go Task Open
To characterize the rat as a potential model of frontal-parietal auditory processing during sustained attention, target detection, and response inhibition, we recorded field potentials (FPs) at multiple sites in medial-dorsal frontal and p…
View article: The GRAVITY Young Stellar Object survey -- I. Probing the disks of Herbig Ae/Be stars in terrestrial orbits
The GRAVITY Young Stellar Object survey -- I. Probing the disks of Herbig Ae/Be stars in terrestrial orbits Open
The formation and the evolution of protoplanetary disks are important stages in the lifetime of stars. The processes of disk evolution and planet formation are intrinsically linked. We spatially resolve with GRAVITY/VLTI in the K-band the …
View article: The GRAVITY Young Stellar Object survey
The GRAVITY Young Stellar Object survey Open
Context. The formation and the evolution of protoplanetary disks are important stages in the lifetime of stars. Terrestrial planets form or migrate within the innermost regions of these protoplanetary disks and so, the processes of disk ev…
View article: First direct detection of an exoplanet by optical interferometry; Astrometry and K-band spectroscopy of HR8799 e
First direct detection of an exoplanet by optical interferometry; Astrometry and K-band spectroscopy of HR8799 e Open
To date, infrared interferometry at best achieved contrast ratios of a few times $10^{-4}$ on bright targets. GRAVITY, with its dual-field mode, is now capable of high contrast observations, enabling the direct observation of exoplanets. W…
View article: First direct detection of an exoplanet by optical interferometry
First direct detection of an exoplanet by optical interferometry Open
Aims . To date, infrared interferometry at best achieved contrast ratios of a few times 10 −4 on bright targets. GRAVITY, with its dual-field mode, is now capable of high contrast observations, enabling the direct observation of exoplanets…
View article: Predicting the Complexity and Progression of the Gut Microbiome Using Temporal Data and Deep Learning
Predicting the Complexity and Progression of the Gut Microbiome Using Temporal Data and Deep Learning Open
The human microbiota exhibit a highly dynamic composition over the course of life and changes in the human gut microbiota have been associated with human health or disease. Reprogramming of the gut microbiota by interventions that counter …
View article: Accretion-ejection morphology of the microquasar SS 433 resolved at sub-au scale
Accretion-ejection morphology of the microquasar SS 433 resolved at sub-au scale Open
We present the first optical observation of the microquasar SS 433 at sub-milliarcsecond (mas) scale obtained with the GRAVITY instrument on the Very Large Telescope interferometer (VLTI). The 3.5-h exposure reveals a rich K -band spectrum…
View article: The 2014 FUN Achievement Award.
The 2014 FUN Achievement Award. Open
The JUNE edition of the FUN 2014 Workshop Proceedings at Ithaca College in 2014 is dedicated to Carol Ann Paul, who died in October 2014. The following provides background on her career achievements as a neuroscience educator, and is based…
View article: An Instructor's Guide to (Some of) the Most Amazing Papers in Neuroscience.
An Instructor's Guide to (Some of) the Most Amazing Papers in Neuroscience. Open
Although textbooks are still assigned in many undergraduate science courses, it is now not uncommon, even in some of the earliest courses in the curriculum, to supplement texts with primary source readings from the scientific literature. N…