Michael Winding
YOU?
Author Swipe
View article: Mapping the fly nerve cord
Mapping the fly nerve cord Open
The first neuronal wiring diagram of an insect nerve cord, which includes biological information on cell type and organisation, enables further investigation into premotor circuit function.
View article: Generative network modeling reveals quantitative definitions of bilateral symmetry exhibited by a whole insect brain connectome
Generative network modeling reveals quantitative definitions of bilateral symmetry exhibited by a whole insect brain connectome Open
Comparing connectomes can help explain how neural connectivity is related to genetics, disease, development, learning, and behavior. However, making statistical inferences about the significance and nature of differences between two networ…
View article: Author response: Generative network modeling reveals quantitative definitions of bilateral symmetry exhibited by a whole insect brain connectome
Author response: Generative network modeling reveals quantitative definitions of bilateral symmetry exhibited by a whole insect brain connectome Open
View article: The connectome of an insect brain
The connectome of an insect brain Open
Brains contain networks of interconnected neurons and so knowing the network architecture is essential for understanding brain function. We therefore mapped the synaptic-resolution connectome of an entire insect brain ( Drosophila larva) w…
View article: The connectome of an insect brain
The connectome of an insect brain Open
Brains contain networks of interconnected neurons, so knowing the network architecture is essential for understanding brain function. We therefore mapped the synaptic-resolution connectome of an insect brain ( Drosophila larva) with rich b…
View article: Generative network modeling reveals quantitative definitions of bilateral symmetry exhibited by a whole insect brain connectome
Generative network modeling reveals quantitative definitions of bilateral symmetry exhibited by a whole insect brain connectome Open
Comparing connectomes can help explain how neural connectivity is related to genetics, disease, development, learning, and behavior. However, making statistical inferences about the significance and nature of differences between two networ…
View article: High-throughput automated methods for classical and operant conditioning of Drosophila larvae
High-throughput automated methods for classical and operant conditioning of Drosophila larvae Open
Learning which stimuli (classical conditioning) or which actions (operant conditioning) predict rewards or punishments can improve chances of survival. However, the circuit mechanisms that underlie distinct types of associative learning ar…
View article: Bisected graph matching improves automated pairing of bilaterally homologous neurons from connectomes
Bisected graph matching improves automated pairing of bilaterally homologous neurons from connectomes Open
Graph matching algorithms attempt to find the best correspondence between the nodes of two networks. These techniques have been used to match individual neurons in nanoscale connectomes—in particular, to find pairings of neurons across hem…
View article: Distance-based positive and unlabeled learning for ranking
Distance-based positive and unlabeled learning for ranking Open
Learning to rank – producing a ranked list of items specific to a query and with respect to a set of supervisory items – is a problem of general interest. The setting we consider is one in which no analytic description of what constitutes …
View article: Author response: High-throughput automated methods for classical and operant conditioning of Drosophila larvae
Author response: High-throughput automated methods for classical and operant conditioning of Drosophila larvae Open
View article: Electrophysiological Validation of Monosynaptic Connectivity between Premotor Interneurons and the aCC Motoneuron in the <i>Drosophila</i> Larval CNS
Electrophysiological Validation of Monosynaptic Connectivity between Premotor Interneurons and the aCC Motoneuron in the <i>Drosophila</i> Larval CNS Open
The Drosophila connectome project aims to map the synaptic connectivity of entire larval and adult fly neural networks, which is essential for understanding nervous system development and function. So far, the project has produced a…
View article: Bisected graph matching improves automated pairing of bilaterally homologous neurons from connectomes
Bisected graph matching improves automated pairing of bilaterally homologous neurons from connectomes Open
Graph matching algorithms attempt to find the best correspondence between the nodes of two networks. These techniques have been used to match individual neurons in nanoscale connectomes – in particular, to find pairings of neurons across h…
View article: Circuits for integrating learned and innate valences in the insect brain.
Circuits for integrating learned and innate valences in the insect brain. Open
Animal behavior is shaped both by evolution and by individual experience. Parallel brain pathways encode innate and learned valences of cues, but the way in which they are integrated during action-selection is not well understood. We used …
View article: Author response: Circuits for integrating learned and innate valences in the insect brain
Author response: Circuits for integrating learned and innate valences in the insect brain Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Animal behavior is sha…
View article: Serotonergic Neurons Mediate Operant Conditioning in <i>Drosophila</i> Larvae
Serotonergic Neurons Mediate Operant Conditioning in <i>Drosophila</i> Larvae Open
Observed across species, operant conditioning facilitates learned associations between behaviours and outcomes, biasing future action selection to maximise reward and avoid punishment. To elucidate the underlying neural mechanisms, we buil…
View article: Distance-based Positive and Unlabeled Learning for Ranking
Distance-based Positive and Unlabeled Learning for Ranking Open
Learning to rank -- producing a ranked list of items specific to a query and with respect to a set of supervisory items -- is a problem of general interest. The setting we consider is one in which no analytic description of what constitute…
View article: Learning to rank via combining representations.
Learning to rank via combining representations. Open
Learning to rank -- producing a ranked list of items specific to a query and with respect to a set of supervisory items -- is a problem of general The setting we consider is one in which no analytic description of what constitutes a good …
View article: Circuits for integrating learnt and innate valences in the fly brain
Circuits for integrating learnt and innate valences in the fly brain Open
Animal behavior is shaped both by evolution and by individual experience. In many species parallel brain pathways are thought to encode innate and learnt behavior drives and as a result may link the same sensory cue to different actions if…
View article: Recurrent architecture for adaptive regulation of learning in the insect brain
Recurrent architecture for adaptive regulation of learning in the insect brain Open
View article: Neural Substrates of Drosophila Larval Anemotaxis
Neural Substrates of Drosophila Larval Anemotaxis Open
View article: Microtubule–microtubule sliding by kinesin-1 is essential for normal cytoplasmic streaming in <i>Drosophila</i> oocytes
Microtubule–microtubule sliding by kinesin-1 is essential for normal cytoplasmic streaming in <i>Drosophila</i> oocytes Open
Significance Generation of mechanical forces by molecular motors is essential for development. Previously, we showed that the microtubule motor kinesin-1 generates forces by sliding microtubules against each other. Here, we show that micro…
View article: Role of kinesin-1–based microtubule sliding in <i>Drosophila</i> nervous system development
Role of kinesin-1–based microtubule sliding in <i>Drosophila</i> nervous system development Open
Significance We previously demonstrated that the microtubule (MT) motor protein kinesin-1 slides and transports MTs themselves in addition to its established role in organelle transport. However, the physiological importance of MT sliding …
View article: Engineered kinesin motor proteins amenable to small-molecule inhibition
Engineered kinesin motor proteins amenable to small-molecule inhibition Open
View article: Engineered kinesin motor proteins amenable to small molecule inhibition
Engineered kinesin motor proteins amenable to small molecule inhibition Open
The human genome encodes 45 kinesins that drive cell division, cell motility, intracellular trafficking, and ciliary function. Determining the cellular function of each kinesin would be greatly facilitated by specific small molecule inhibi…
View article: A Genome-wide RNAi Screen for Microtubule Bundle Formation and Lysosome Motility Regulation in Drosophila S2 Cells
A Genome-wide RNAi Screen for Microtubule Bundle Formation and Lysosome Motility Regulation in Drosophila S2 Cells Open
Long-distance intracellular transport of organelles, mRNA, and proteins ("cargo") occurs along the microtubule cytoskeleton by the action of kinesin and dynein motor proteins, but the vast network of factors involved in regulating intracel…
View article: Interplay between kinesin-1 and cortical dynein during axonal outgrowth and microtubule organization in Drosophila neurons
Interplay between kinesin-1 and cortical dynein during axonal outgrowth and microtubule organization in Drosophila neurons Open
In this study, we investigated how microtubule motors organize microtubules in Drosophila neurons. We showed that, during the initial stages of axon outgrowth, microtubules display mixed polarity and minus-end-out microtubules push the tip…
View article: Author response: Interplay between kinesin-1 and cortical dynein during axonal outgrowth and microtubule organization in Drosophila neurons
Author response: Interplay between kinesin-1 and cortical dynein during axonal outgrowth and microtubule organization in Drosophila neurons Open
Full text Figures and data Side by side Abstract eLife digest Introduction Results Discussion Material and methods References Decision letter Author response Article and author information Metrics Abstract In this study, we investigated ho…