Explanipedia

Differential ion selectivity and disease-associated dysfunction of TRPML channels revealed by patient and engineered mutants Open

Braden E Rue, Anna Dischler, Lyndsie A. Salvagio, Michael X. Zhu, Gang Xu , et al. · 2025

The endolysosomal TRPML (transient receptor potential mucolipin) channels play key roles in regulating lysosomal trafficking, signaling, and function. While mutations in TRPML1 cause mucolipidosis type IV (MLIV), the functional consequence…

Neuropeptide Y co-opts neuronal ensembles for memory lability and stability Open

Tian‐Le Xu, Yan‐Jiao Wu, Xue Gu, Yalei Kong, Shuo Yang , et al. · 2025

Memory engrams are formed by activity-dependent recruitment of distinct subsets of excitatory principal neurons (or neuronal ensembles) whereas inhibitory neurons pivot memory lability and stability. However, the molecular logic for memory…

DHHC21 is a STIM1 protein S-acyltransferase that modulates immune function <i>in vivo</i> Open

Goutham Kodakandla, Ying Fan, Michael X. Zhu, Savannah J. West, Askar M. Akimzhanov , et al. · 2025

Depletion of calcium from ER stores leads to the activation of calcium channels on the plasma membrane. This process is termed store-operated calcium entry (SOCE). The proteins STIM1 and STIM2 function as ER calcium sensors, and upon store…

Education Outcomes from an Ophthalmology Microsurgery Course for Medical Students Open

Michael X. Zhu, Keke Liu, Joanne C. Wen, Sandra S. Stinnett, Jullia A. Rosdahl · 2025

Retraction Note: VPAC1 couples with TRPV4 channel to promote calcium-dependent gastric cancer progression via a novel autocrine mechanism Open

Bo Tang, Jilin Wu, Michael X. Zhu, Xuemei Sun, Jingjing Liu , et al. · 2025

Repurposing salicylic acid as a versatile inducer of proximity Open

Tianlu Wang, Siyao Liu, Yuepeng Ke, Sher Ali, Rui Wang , et al. · 2025

Transient Receptor Potential channels (TRP) in GtoPdb v.2025.1 Open

Nathaniel T. Blair, David D. McKemy, Bernd Nilius, Elena Oancea, Grzegorz Owsianik , et al. · 2025

The TRP superfamily of channels (nomenclature as agreed by NC-IUPHAR [177, 1080]), whose founder member is the Drosophila Trp channel, exists in mammals as six families; TRPC, TRPM, TRPV, TRPA, TRPP and TRPML based on amino acid homologies…

Targeting TRPC channels for control of arthritis-induced bone erosion Open

Suravi Ray, Jamie L. McCall, Jinbin Tian, Jaepyo Jeon, Aidan Douglas , et al. · 2025

Arthritis leads to bone erosion due to an imbalance between osteoclast and osteoblast function. Our prior investigations revealed that the Ca 2+ -selective ion channel, Orai1, is critical for osteoclast maturation. Here, we show that the s…

Transcriptomic Profile Analysis of Brain Tissue in the Absence of Functional TRPM8 Calcium Channel Open

Erick Benjamin Saldes, Alexandra Erdmier, Jai Velpula, Timothy E. Koeltzow, Michael X. Zhu , et al. · 2024

Background/Objectives: Transient Receptor Potential Melastatin 8 (TRPM8) is a non-selective, Ca2+-permeable cation channel involved in thermoregulation and other physiological processes, such as basal tear secretion, cell differentiation, …

Stimulation of an entorhinal-hippocampal extinction circuit facilitates fear extinction in a post-traumatic stress disorder model Open

Ze-Jie Lin, Xue Gu, W. Gong, Mo Wang, Yan‐Jiao Wu , et al. · 2024

Effective psychotherapy of post-traumatic stress disorder (PTSD) remains challenging owing to the fragile nature of fear extinction, for which the ventral hippocampal CA1 (vCA1) region is considered as a central hub. However, neither the c…

A thalamic nucleus reuniens–lateral septum–lateral hypothalamus circuit for comorbid anxiety–like behaviors in chronic itch Open

Su-Shan Guo, Yu Gong, Tingting Zhang, Xin-Yu Su, Yan‐Jiao Wu , et al. · 2024

Chronic itch often clinically coexists with anxiety symptoms, creating a vicious cycle of itch-anxiety comorbidities that are difficult to treat. However, the neuronal circuit mechanisms underlying the comorbidity of anxiety in chronic itc…

Sensory ASIC3 channel exacerbates psoriatic inflammation via a neurogenic pathway in female mice Open

Chen Huang, Peiyi Sun, Yiming Jiang, Yuandong Liu, Zhichao Liu , et al. · 2024

Psoriasis is an immune-mediated skin disease associated with neurogenic inflammation, but the underlying molecular mechanism remains unclear. We demonstrate here that acid-sensing ion channel 3 (ASIC3) exacerbates psoriatic inflammation th…

Hijacking a dedicated entorhinal-hippocampal extinction circuit to remove traumatic memory Open

Ze-Jie Lin, Xuefeng Gu, W. Gong, Mo Wang, Yan‐Jiao Wu , et al. · 2024

Effective psychotherapy of post-traumatic stress disorder (PTSD) remains challenging due to the fragile nature of fear extinction, for which ventral hippocampal CA1 (vCA1) region is considered as a central hub. However, neither the core pa…

Neuropeptide Y co-opts neuronal ensembles for memory lability and stability Open

Yan‐Jiao Wu, Xue Gu, Yalei Kong, Shuo Yang, Huan Wang , et al. · 2024

Memory engrams are formed by activity-dependent recruitment of distinct subsets of excitatory principal neurons (or neuronal ensembles) whereas inhibitory neurons pivot memory lability and stability 1–5 . However, the molecular logic for m…

Volumetric segmentation in the context of posterior fossa-related pathologies: a systematic review Open

Andrew J. Kobets, Seyed Ahmad Naseri Alavi, Samuel Ahmad, Ashley Castillo, Dejauwne L. Young , et al. · 2024

Background Segmentation tools continue to advance, evolving from manual contouring to deep learning. Researchers have utilized segmentation to study a myriad of posterior fossa-related conditions, such as Chiari malformation, trigeminal ne…

Widespread latent hyperactivity of nociceptors outlasts enhanced avoidance behavior following incision injury Open

Alexis Bavencoffe, Elia R. Lopez, Kayla N. Johnson, Jinbin Tian, Falih M. Gorgun , et al. · 2024

Nociceptors with somata in dorsal root ganglia (DRGs) exhibit an unusual readiness to switch from an electrically silent state to a hyperactive state of tonic, nonaccommodating, low-frequency, irregular discharge of action potentials (APs)…

A shared mechanism for TNP-ATP recognition by members of the P2X receptor family Open

Xiaobo Ma, Chen-Xi Yue, Yan Liu, Yang Yang, Jin Wang , et al. · 2023

Transient Receptor Potential channels (TRP) in GtoPdb v.2023.3 Open

Nathaniel T. Blair, Ana I. Caceres, Ingrid Carvacho, Dipayan Chaudhuri, David E. Clapham , et al. · 2023

The TRP superfamily of channels (nomenclature as agreed by NC-IUPHAR [176, 1075]), whose founder member is the Drosophila Trp channel, exists in mammals as six families; TRPC, TRPM, TRPV, TRPA, TRPP and TRPML based on amino acid homologies…

hnRNPA1 SUMOylation promotes cold hypersensitivity in chronic inflammatory pain by stabilizing TRPA1 mRNA Open

Qiao Zhang, Weiji Weng, Xiaokun Gu, Jinhua Xiang, Yang Yang , et al. · 2023

TRPA1 is pivotal in cold hypersensitivity, but its regulatory mechanisms in inflammatory cold hyperalgesia remain poorly understood. We show here that the upregulation of SUMO1-conjugated protein levels in a complete Freund's adjuvant (CFA…

Readiness of nociceptor cell bodies to generate spontaneous activity results from background activity of diverse ion channels and high input resistance Open

Jinbin Tian, Alexis Bavencoffe, Michael X. Zhu, Edgar T. Walters · 2023

Nociceptor cell bodies generate “spontaneous” discharge that can promote ongoing pain in persistent pain conditions. Little is known about the underlying mechanisms. Recordings from nociceptor cell bodies (somata) dissociated from rodent a…

The Concise Guide to PHARMACOLOGY 2023/24: Ion channels Open

S P H Alexander, Alistair Mathie, John A. Peters, Emma L. Veale, Jörg Striessnig , et al. · 2023

The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000…

Chronic cough relief by allosteric modulation of P2X3 without taste disturbance Open

Chang-Run Guo, Zhong-Zhe Zhang, Xing Zhou, Mengyang Sun, Tiantian Li , et al. · 2023

N-terminal α-amino SUMOylation of cofilin-1 is critical for its regulation of actin depolymerization Open

Weiji Weng, Xiaokun Gu, Yang Yang, Qiao Zhang, Qi Deng , et al. · 2023

Small ubiquitin-like modifier (SUMO) typically conjugates to target proteins through isopeptide linkage to the ε-amino group of lysine residues. This posttranslational modification (PTM) plays pivotal roles in modulating protein function. …

Transient Receptor Potential channels (TRP) in GtoPdb v.2023.2 Open

Nathaniel T. Blair, Ana I. Caceres, Ingrid Carvacho, Dipayan Chaudhuri, David E. Clapham , et al. · 2023

The TRP superfamily of channels (nomenclature as agreed by NC-IUPHAR [176, 1072]), whose founder member is the Drosophila Trp channel, exists in mammals as six families; TRPC, TRPM, TRPV, TRPA, TRPP and TRPML based on amino acid homologies…

Readiness of nociceptor cell bodies to generate spontaneous activity results from background activity of diverse ion channels and high input resistance Open

Jinbin Tian, Alexis Bavencoffe, Michael X. Zhu, Edgar T. Walters · 2023

Nociceptor cell bodies generate “spontaneous” discharge that can promote ongoing pain in persistent pain conditions. Little is known about the underlying mechanisms. Recordings from nociceptor cell bodies (somata) dissociated from rodent a…

Chromogranin B (CHGB) is dimorphic and responsible for dominant anion channels delivered to cell surface via regulated secretion Open

Gaya P. Yadav, Haiyuan Wang, Joke Ouwendijk, Stephen Cross, Qiaochu Wang , et al. · 2023

Regulated secretion is conserved in all eukaryotes. In vertebrates granin family proteins function in all key steps of regulated secretion. Phase separation and amyloid-based storage of proteins and small molecules in secretory granules re…

Surgical management of placenta percreta complicated by bladder invasion: a case report Open

Benjamin Green, Michael X. Zhu, Justin Loloi, Rutul D. Patel, Alexander Small · 2023

Background: Urologic complications of placenta accreta spectrum (PAS) are relatively rare but can be severe. To our knowledge, this is the first case to result in the simultaneous combination of massive hemorrhage, inadvertent cystotomy, b…

Transient Receptor Potential channels (TRP) in GtoPdb v.2023.1 Open

Nathaniel T. Blair, Ingrid Carvacho, Dipayan Chaudhuri, David E. Clapham, Katrien De Clercq , et al. · 2023

The TRP superfamily of channels (nomenclature as agreed by NC-IUPHAR [176, 1072]), whose founder member is the Drosophila Trp channel, exists in mammals as six families; TRPC, TRPM, TRPV, TRPA, TRPP and TRPML based on amino acid homologies…

Data from Calcium Promotes Human Gastric Cancer via a Novel Coupling of Calcium-Sensing Receptor and TRPV4 Channel Open

Rui Xie, Jingyu Xu, Yufeng Xiao, Jilin Wu, Hanxing Wan , et al. · 2023

Although dietary calcium intake has long been recommended for disease prevention, the influence of calcium in development of cancer in the upper gastrointestinal tract has not been explored. Here, we assess the roles of calcium and calcium…

Supplementary Figure 1-8 from Calcium Promotes Human Gastric Cancer via a Novel Coupling of Calcium-Sensing Receptor and TRPV4 Channel Open

Rui Xie, Jingyu Xu, Yufeng Xiao, Jilin Wu, Hanxing Wan , et al. · 2023

Supplementray Figure 1. Effect of CaCl2 on PCNA protein expression in GC cells and xenografed gastric tumors. Supplementray Figure 2. The efficiencies of CaSR shRNA transient transfection into MKN45 cells and CaSR shRNA lentiviruses transf…

Michael X. Zhu YOU? Author Swipe