Explanipedia

Anti-Tumoral Treatment with Thioredoxin Reductase 1 Inhibitor Auranofin Fosters Regulatory T Cell and B16F10 Expansion in Mice Open

Michael Y. Bonner, Christian M. Beusch, Kejsi Zeqiraj, Roman A. Zubarev, Elias S.J. Arnér , et al. · 2025

Auranofin, an FDA-approved antirheumatic drug and thioredoxin reductase 1 (TXNRD1) inhibitor, has demonstrated anti-tumoral properties, but its immunological effects are not well characterized. Here, we report that auranofin unexpectedly p…

Glycan Activation of Clec4b Induces Reactive Oxygen Species Protecting against Neutrophilia and Arthritis Open

Mike Aoun, Xiaojie Cai, Bingze Xu, Gonzalo Fernandez Lahore, Michael Y. Bonner , et al. · 2021

Animal models for complex diseases are needed to position and analyze the function of interacting genes. Previous positional cloning identified Ncf1 and Clec4b to be major regulators of arthritis models in rats. Here, we investigate epista…

Correction: da Costa et al. Establishment of a Temperature-Sensitive Model of Oncogene-Induced Senescence in Angiosarcoma Cells. Cancers 2020, 12, 395 Open

Adilson Costa, Michael Y. Bonner, Shikha Rao, Linda Gilbert, Maiko Sasaki , et al. · 2021

The authors wish to make the following corrections to this paper [...]

An Optimized Model of Hypertrophic Preconditioning Confers Cardioprotection in the Mouse Open

Xiaojie Cai, Yuling Tian, Yue Wu, Michael Y. Bonner, Xiaozhen Zhuo , et al. · 2021

Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation Open

Ulrika Norin, Carola Rintisch, Liesu Meng, Florian Förster, Diana Ekman , et al. · 2021

Establishment of a Temperature-Sensitive Model of Oncogene-Induced Senescence in Angiosarcoma Cells Open

Adilson Costa, Michael Y. Bonner, Shikha Rao, Linda Gilbert, Maiko Sasaki , et al. · 2020

Lesions with driver mutations, including atypical nevi and seborrheic keratoses, are very common in dermatology, and are prone to senescence. The molecular events that prevent senescent lesions from becoming malignant are not well understo…

Tris DBA palladium is an orally available inhibitor of GNAQ mutant uveal melanoma <i>in vivo</i> Open

Elgilda Musi, Gary K. Schwartz, Jae Hyuk Yoo, Shannon J. Odelberg, Dean Y. Li , et al. · 2019

Uveal melanoma is a rare but often lethal malignancy and is the leading cause of death due to an ophthalmic condition. Uveal melanoma is often diagnosed at a late stage and has a strong propensity to hepatic metastasis. Recently, the most …

Evidence for biochemical barrier restoration: Topical solenopsin analogs improve inflammation and acanthosis in the KC-Tie2 mouse model of psoriasis Open

Jack L. Arbiser, Ron Nowak, Kellie A. Michaels, Yuliya Skabytska, Tilo Biedermann , et al. · 2017

Psoriasis is a chronic inflammatory skin disease affecting 2.5–6 million patients in the United States. The cause of psoriasis remains unknown. Previous human and animal studies suggest that patients with a susceptible genetic background a…

Targeting the duality of cancer Open

Jack L. Arbiser, Michael Y. Bonner, Linda Gilbert · 2017

Cancer is the second leading cause of death in the United States, and is an increasing cause of death in the developing world. While there is great heterogeneity in the anatomic site and mutations involved in human cancer, there are common…

Activation of Protein Kinase C ε in Merkel Cell Polyomavirus–Induced Merkel Cell Carcinoma Open

Adilson Costa, Jamie MacKelfresh, Linda Gilbert, Michael Y. Bonner, Jack L. Arbiser · 2017

This study of 11 Merkel cell carcinoma samples explored the association of activated protein kinase C ε and Merkel cell carcinoma–associated polyoma virus.

Erratum to: Honokiol activates AMP-activated protein kinase in breast cancer cells via LKB1-dependent pathway and inhibits breast carcinogenesis Open

Arumugam Nagalingam, Jack L. Arbiser, Michael Y. Bonner, Neeraj K. Saxena, Dipali Sharma · 2017

Honokiol protects skin cells against inflammation, collagenolysis, apoptosis, and senescence caused by cigarette smoke damage Open

Adilson Costa, Gustavo Facchini, Ana Lúcia Tabarini Alves Pinheiro, Michelle Sabrina da Silva, Michael Y. Bonner , et al. · 2017

Background Pollution, especially cigarette smoke, is a major cause of skin damage. Objectives To assess the effects of the small molecule polyphenol, honokiol, on reversing cigarette smoke‐induced damage in vitro to relevant skin cells. Me…

SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis Open

Kaname Akamata, Jun Wei, Mitra Bhattacharyya, Paul Cheresh, Michael Y. Bonner , et al. · 2016

Constitutive fibroblast activation is responsible for organ fibrosis in fibrotic disorders including systemic sclerosis (SSc), but the underlying mechanisms are not fully understood, and effective therapies are lacking. We investigated the…

Pro-Apoptotic Activity of New Honokiol/Triphenylmethane Analogues in B-Cell Lymphoid Malignancies Open

Aleksandra Mędra, Magdalena Witkowska, Agata Majchrzak, Barbara Cebula‐Obrzut, Michael Y. Bonner , et al. · 2016

Honokiol and triphenylmethanes are small molecules with anti-tumor properties. Recently, we synthesized new honokiol analogues (HAs) that possess common features of both groups. We assessed the anti-tumor effectiveness of HAs in B-cell leu…

Cooperation of imipramine blue and tyrosine kinase blockade demonstrates activity against chronic myeloid leukemia Open

Kamilla M. E. Laidlaw, Samuel Berhan, Suhu Liu, Giovannino Silvestri, Tessa L. Holyoake , et al. · 2016

The use of tyrosine kinase inhibitors (TKI), including nilotinib, has revolutionized the treatment of chronic myeloid leukemia (CML). However current unmet clinical needs include combating activation of additional survival signaling pathwa…

Tris DBA palladium is highly effective against growth and metastasis of pancreatic cancer in an orthotopic model Open

Begoña Díaz, Katherine T. Ostapoff, Jason E. Toombs, Jason Lo, Michael Y. Bonner , et al. · 2016

Pancreatic carcinoma ranks among the most lethal of human cancers. Besides late detection, other factors contribute to its lethality, including a high degree of chemoresistance, invasion, and distant metastases. Currently, the mainstay of …

Use of Polyphenolic Compounds in Dermatologic Oncology Open

Adilson Costa, Michael Y. Bonner, Jack L. Arbiser · 2016

Tuberculosis verrucosa cutis lesions exhibit a greater microvessel count than lupus vulgaris lesions Open

Sulochana S. Bhandarkar, Padmavathy Lanka, Lakshmana Rao Lanka, Emir Veledar, Michael Y. Bonner , et al. · 2016

Tuberculosis is reported to be the second most common infectious cause of death after HIV. The causative organism of tuberculosis, Mycobacterium tuberculosis (MTB), is capable of infecting virtually every organ of the body, including the s…

Seborrheic Keratoses: The Rodney Dangerfield of Skin lesions, and Why They Should Get Our Respect Open

Jack L. Arbiser, Michael Y. Bonner · 2016

Honokiol bis-dichloroacetate (Honokiol DCA) demonstrates activity in vemurafenib-resistant melanoma<i>in vivo</i> Open

Michael Y. Bonner, Isabella Karlsson, Monica Rodolfo, Rebecca S. Arnold, Elisabetta Vergani , et al. · 2016

The majority of human melanomas bears BRAF mutations and thus is treated with inhibitors of BRAF, such as vemurafenib. While patients with BRAF mutations often demonstrate an initial dramatic response to vemurafenib, relapse is extremely c…

Honokiol activates LKB1-miR-34a axis and antagonizes the oncogenic actions of leptin in breast cancer Open

Dimiter Avtanski, Arumugam Nagalingam, Michael Y. Bonner, Jack L. Arbiser, Neeraj K. Saxena , et al. · 2015

Leptin, a major adipocytokine produced by adipocytes, is emerging as a key molecule linking obesity with breast cancer therefore, it is important to find effective strategies to antagonize oncogenic effects of leptin to disrupt obesity-can…

Solenopsin A and analogs exhibit ceramide-like biological activity Open

Isabella Karlsson, Xin Zhou, Raquela J. Thomas, Allorie T Smith, Michael Y. Bonner , et al. · 2015

The requirements for ceramide induced mitophagy and inhibition of Akt activity and PDK1 activation in lipid rafts are under strict stereochemical control. The naturally occurring (-)-solenopsin A mimic some of the functions of ceramide and…

Honokiol abrogates leptin-induced tumor progression by inhibiting Wnt1-MTA1-β-catenin signaling axis in a microRNA-34a dependent manner Open

Dimiter Avtanski, Arumugam Nagalingam, Panjamurthy Kuppusamy, Michael Y. Bonner, Jack L. Arbiser , et al. · 2015

Obesity greatly influences risk, progression and prognosis of breast cancer. As molecular effects of obesity are largely mediated by adipocytokine leptin, finding effective novel strategies to antagonize neoplastic effects of leptin is des…

Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3 Open

Vinodkumar B. Pillai, Sadhana Samant, Nagalingam R. Sundaresan, H. Raghuraman, Gene Kim , et al. · 2015

Inactivation of NADPH Oxidases NOX4 and NOX5 Protects Human Primary Fibroblasts from Ionizing Radiation-Induced DNA Damage Open

Urbain Weyemi, Christophe E. Redon, Towqir Aziz, Rohini Choudhuri, Daisuke Maeda , et al. · 2015

Human exposure to ionizing radiation from medical procedures has increased sharply in the last three decades. Recent epidemiological studies suggest a direct relationship between exposure to ionizing radiation and health problems, includin…

NADPH oxidase 4 is a critical mediator in Ataxia telangiectasia disease Open

Urbain Weyemi, Christophe E. Redon, Towqir Aziz, Rohini Choudhuri, Daisuke Maeda , et al. · 2015

Significance Ataxia telangiectasia (A-T) is a rare, autosomal recessive disorder characterized by progressive cerebellar degeneration. Oxidative stress is one cause of the symptoms of A-T disease. We report that inactivation of NADPH oxida…

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