Michael A. Yassa
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View article: Revealing Spatial Patterns of Tau‐Related White Matter Disruption in Humans <i>in Vivo</i>
Revealing Spatial Patterns of Tau‐Related White Matter Disruption in Humans <i>in Vivo</i> Open
Background Tau pathology may contribute to the disruption of white matter (WM) integrity in Alzheimer's disease (AD). While previous work has shown global disruption to WM tracts, the specific spatial locations along the impacted tracts wi…
View article: The Space Between: Exploring Perivascular Pathways of Alzheimer’s Disease Risk Detection
The Space Between: Exploring Perivascular Pathways of Alzheimer’s Disease Risk Detection Open
Background Perivascular spaces (PVS) are small, fluid‐filled spaces surrounding cerebral blood vessels which facilitate metabolic transport and waste clearance. When this clearance process is disrupted, PVS become visible on magnetic reson…
View article: Evaluating Plasma Ptau‐217 Sensitivity in Detecting Individual Differences in Early‐stage Tau Aggregation in Cognitively Unimpaired Older Adults
Evaluating Plasma Ptau‐217 Sensitivity in Detecting Individual Differences in Early‐stage Tau Aggregation in Cognitively Unimpaired Older Adults Open
Background Plasma ptau‐217 is a promising biomarker for detecting Alzheimer's pathology. However, previous studies show no or weak correlations between plasma ptau‐217 and tau‐PET in cognitively unimpaired (CU) individuals. This is possibl…
View article: Revealing Spatial Patterns of Tau‐Related White Matter Disruption in Humans <i>in Vivo</i>
Revealing Spatial Patterns of Tau‐Related White Matter Disruption in Humans <i>in Vivo</i> Open
Background Tau pathology may contribute to the disruption of white matter (WM) integrity in Alzheimer’s disease (AD). While previous work has shown global disruption to WM tracts, the specific spatial locations along the impacted tracts wi…
View article: Lower amyloid and small vessel disease in unimpaired older adults with Down syndrome
Lower amyloid and small vessel disease in unimpaired older adults with Down syndrome Open
Background The revised Alzheimer's Association Research Framework presumes that all adults with Down syndrome (DS) are on the Alzheimer's disease (AD) continuum, developing AD at a median age of 54 years old after lifelong overproduction o…
View article: Self‐reported sleep duration in relation to brain MRI measures across pre‐symptomatic continuum in older adults age 90+
Self‐reported sleep duration in relation to brain MRI measures across pre‐symptomatic continuum in older adults age 90+ Open
Background Previous research found the association of long sleep with lower total brain and gray matter volumes in older adults. It is unclear, however, whether this association is modified by amyloid status in cognitively unimpaired indiv…
View article: Sex‐specific effects of estradiol on regional amyloid‐β, white matter integrity, and hippocampal‐dependent memory in cognitively unimpaired older adults
Sex‐specific effects of estradiol on regional amyloid‐β, white matter integrity, and hippocampal‐dependent memory in cognitively unimpaired older adults Open
Background Evidence suggests menopause‐driven estradiol withdrawal increases vulnerability to AD pathogenesis in women. While studies have shown women and men accumulate global amyloid‐β (Aβ) at similar rates, the regional specificity of s…
View article: Functional connectivity differences in the default mode and frontoparietal networks in older adults with Down syndrome are related to obstructive sleep apnea
Functional connectivity differences in the default mode and frontoparietal networks in older adults with Down syndrome are related to obstructive sleep apnea Open
Background There is disrupted functional connectivity (FC) of the default mode network (DMN) and frontoparietal network (FPN) in adults with obstructive sleep apnea (OSA). DMN FC is also particularly sensitive to disruption in Alzheimer’s …
View article: Evaluating Plasma Ptau‐217 Sensitivity in Detecting Individual Differences in Early‐stage Tau Aggregation in Cognitively Unimpaired Older Adults
Evaluating Plasma Ptau‐217 Sensitivity in Detecting Individual Differences in Early‐stage Tau Aggregation in Cognitively Unimpaired Older Adults Open
Background Plasma ptau‐217 is a promising biomarker for detecting Alzheimer's pathology. However, previous studies show no or weak correlations between plasma ptau‐217 and tau‐PET in cognitively unimpaired (CU) individuals. This is possibl…
View article: A compressed code for memory discrimination
A compressed code for memory discrimination Open
The ability to discriminate similar visual stimuli has been used as an important index of memory function. This ability is widely thought to be supported by expanding the dimensionality of relevant neural codes, such that neural representa…
View article: Age-related constraints on the spatial geometry of the brain
Age-related constraints on the spatial geometry of the brain Open
Age-related structural brain changes may be better captured by assessing complex spatial geometric differences rather than isolated changes to individual regions. We applied an analytic method to quantify age-related changes to the spatial…
View article: Alzheimer's disease diagnostic progression is associated with cerebrovascular disease and neuroinflammation in adults with Down syndrome
Alzheimer's disease diagnostic progression is associated with cerebrovascular disease and neuroinflammation in adults with Down syndrome Open
INTRODUCTION Despite having few vascular risk factors, people with Down syndrome (DS) have MRI evidence of cerebrovascular disease (CVD) and neuroinflammation that worsens with Alzheimer's disease (AD) severity. We investigated whether mar…
View article: A Combined Neuroanatomy, Ex Vivo Imaging, and Immunohistochemistry Defined <scp>MRI</scp> Mask for the Human Paraventricular Nucleus of the Thalamus
A Combined Neuroanatomy, Ex Vivo Imaging, and Immunohistochemistry Defined <span>MRI</span> Mask for the Human Paraventricular Nucleus of the Thalamus Open
The paraventricular nucleus of the thalamus (PVT) is an evolutionarily conserved midline thalamic structure known to contribute to arousal, interoceptive states, and motivated behaviors. Yet, a consensus anatomical definition of the human …
View article: Alzheimer Disease Biomarkers and Subjective Cognitive Decline Among Hispanic and/or Latino Adults
Alzheimer Disease Biomarkers and Subjective Cognitive Decline Among Hispanic and/or Latino Adults Open
Importance Subjective cognitive decline (SCD) may be an early indicator of Alzheimer disease and related dementias (ADRD), yet its association with plasma biomarkers remains unclear among middle-aged and older adults (aged 50-86 years). Ob…
View article: Longitudinal changes in white matter hyperintensity volume accelerate across the Alzheimer's continuum in adults with Down syndrome
Longitudinal changes in white matter hyperintensity volume accelerate across the Alzheimer's continuum in adults with Down syndrome Open
INTRODUCTION Cerebrovascular disease is elevated across the Alzheimer's disease (AD) continuum in adults with Down syndrome (DS), but regional change within individuals is unknown. METHODS Participants from the Alzheimer's Biomarker Consor…
View article: Preliminary Investigation of Obstructive Sleep Apnea and Alzheimer’s Disease in Down Syndrome
Preliminary Investigation of Obstructive Sleep Apnea and Alzheimer’s Disease in Down Syndrome Open
This study provided a preliminary examination of indices of obstructive sleep apnea (OSA) and sleep disruptions in adults with Down syndrome (DS), and their associations with Alzheimer’s disease (AD) pathology and symptomatology. Ninety-th…
View article: Individual differences in medial temporal lobe functional network architecture predict the capacity for sleep-related consolidation of emotional memories in older adults
Individual differences in medial temporal lobe functional network architecture predict the capacity for sleep-related consolidation of emotional memories in older adults Open
Study Objectives Memory consolidation during non-rapid eye movement slow wave sleep (NREM SWS) involves reactivation of a hippocampal index which integrates distributed cortical representations of an experience. This study examined whether…
View article: A combined neuroanatomy, ex vivo imaging and immunohistochemistry defined MRI mask for the human paraventricular nucleus of the thalamus
A combined neuroanatomy, ex vivo imaging and immunohistochemistry defined MRI mask for the human paraventricular nucleus of the thalamus Open
The paraventricular nucleus of the thalamus (PVT) is an evolutionarily conserved midline thalamic structure known to contribute to arousal, interoceptive states, and motivated behaviors. Yet, a consensus anatomical definition of the human …
View article: Correlating hippocampal and amygdala volumes with neuropathological burden in Down syndrome and Alzheimer’s disease and related neurodegenerative pathologies using 7T postmortem MRI
Correlating hippocampal and amygdala volumes with neuropathological burden in Down syndrome and Alzheimer’s disease and related neurodegenerative pathologies using 7T postmortem MRI Open
Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC), is common in elderly brains and often seen in conjunction with Alzheimer’s disease neuropathologic change (ADNC). LATE-NC typically begins in the amygda…
View article: Amyloid-Beta Deposition in Basal Frontotemporal Cortex Is Associated with Selective Disruption of Temporal Mnemonic Discrimination
Amyloid-Beta Deposition in Basal Frontotemporal Cortex Is Associated with Selective Disruption of Temporal Mnemonic Discrimination Open
Cerebral amyloid-beta (Aβ) accumulation, a hallmark pathology of Alzheimer's disease (AD), precedes clinical impairment by two to three decades. However, it is unclear whether Aβ contributes to subtle memory deficits observed during the pr…
View article: NODDI-derived measures of microstructural integrity in medial temporal lobe white matter pathways are associated with Alzheimer’s disease pathology and cognition
NODDI-derived measures of microstructural integrity in medial temporal lobe white matter pathways are associated with Alzheimer’s disease pathology and cognition Open
Diffusion tensor imaging has traditionally been used to assess white matter (WM) integrity in Alzheimer’s disease (AD). However, the tensor model is limited in modeling complex WM structure. Neurite Orientation Dispersion and Density Imagi…
View article: A comparison of multiple amyloid PET radiotracers for Down syndrome clinical trials
A comparison of multiple amyloid PET radiotracers for Down syndrome clinical trials Open
Adults with Down syndrome carry high risk of developing Alzheimer’s disease and efforts to include this population in clinical trials remain limited. A barrier to recruitment for anti-amyloid trials includes the availability of the same am…
View article: Engagement in moderate-intensity physical activity supports overnight memory retention in older adults
Engagement in moderate-intensity physical activity supports overnight memory retention in older adults Open
Preserving the ability to vividly recall emotionally rich experiences contributes to quality of life in older adulthood. While prior works suggest that moderate-intensity physical activity (MPA) may bolster memory, it is unclear whether th…
View article: Compression and expansion in the aging brain is associated with clinical and cognitive outcomes
Compression and expansion in the aging brain is associated with clinical and cognitive outcomes Open
Background The brain undergoes structural changes during aging, such as gray matter loss, enlarged ventricles, and sulcal widening. However, previous studies have primarily investigated these changes in isolation, without describing the co…
View article: NODDI measures of microstructural integrity in medial temporal lobe white matter pathways are associated with Alzheimer's disease pathology and cognitive outcomes
NODDI measures of microstructural integrity in medial temporal lobe white matter pathways are associated with Alzheimer's disease pathology and cognitive outcomes Open
Background Diffusion tensor imaging has traditionally been used to assess white matter (WM) integrity in Alzheimer’s disease (AD). However, the tensor model is limited in modeling complex WM structure. Neurite Orientation Dispersion and De…
View article: Interplay of inflammatory, vascular, and Alzheimer’s disease biomarkers in cognitively unimpaired older adults
Interplay of inflammatory, vascular, and Alzheimer’s disease biomarkers in cognitively unimpaired older adults Open
Background Neuroinflammatory processes, assessed by cytokines such as interleukins, are implicated in vascular disease and amyloid‐β (Aβ) burden. White matter hyperintensities (WMH), markers of small vessel cerebrovascular disease, are ass…
View article: Brain Volumetric Trajectories in Down Syndrome and Autosomal Dominant Alzheimer Disease
Brain Volumetric Trajectories in Down Syndrome and Autosomal Dominant Alzheimer Disease Open
Background Alzheimer disease (AD) related cognitive decline occurs at relatively young ages in individuals with Down syndrome (DS, early‐mid 50s) and in those with autosomal dominant mutations (ADAD, 40‐50s). Both groups show similar patte…