Michaela Huber
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View article: ProQ-associated small RNAs control motility in <i>Vibrio cholerae</i>
ProQ-associated small RNAs control motility in <i>Vibrio cholerae</i> Open
Gene regulation at the post-transcriptional level is prevalent in all domains of life. In bacteria, ProQ-like proteins have emerged as important RNA chaperones facilitating RNA stability and RNA duplex formation. In the major human pathoge…
View article: Genome-wide profiling of Hfq-bound RNAs reveals the iron-responsive small RNA RusT in <i>Caulobacter crescentus</i>
Genome-wide profiling of Hfq-bound RNAs reveals the iron-responsive small RNA RusT in <i>Caulobacter crescentus</i> Open
The alphaproteobacterium Caulobacter crescentus thrives in oligotrophic environments and is able to optimally exploit minimal resources by entertaining an intricate network of gene expression control mechanisms. Numerous transcriptional ac…
View article: An RNA sponge controls quorum sensing dynamics and biofilm formation in Vibrio cholerae
An RNA sponge controls quorum sensing dynamics and biofilm formation in Vibrio cholerae Open
Small regulatory RNAs (sRNAs) acting in concert with the RNA chaperone Hfq are prevalent in many bacteria and typically act by base-pairing with multiple target transcripts. In the human pathogen Vibrio cholerae , sRNAs play roles in vario…
View article: Towards maximum acceleration of monoclonal antibody development: Leveraging transposase-mediated cell line generation to enable GMP manufacturing within 3 months using a stable pool
Towards maximum acceleration of monoclonal antibody development: Leveraging transposase-mediated cell line generation to enable GMP manufacturing within 3 months using a stable pool Open
In recent years, acceleration of development timelines has become a major focus within the biopharmaceutical industry to bring innovative therapies faster to patients. However, in order to address a high unmet medical need even faster furt…
View article: Small RNA directs symbiosis, virulence, and natural products biosynthesis in entomopathogenic bacteria
Small RNA directs symbiosis, virulence, and natural products biosynthesis in entomopathogenic bacteria Open
Rapid modulation of gene expression is a key feature for the success of bacteria, particularly for those that rapidly have to adapt to different niches. The lifecycles of Photorhabdus and Xenorhabdus involve a mutualistic association with …
View article: Gene autoregulation by 3’ UTR-derived bacterial small RNAs
Gene autoregulation by 3’ UTR-derived bacterial small RNAs Open
Negative feedback regulation, that is the ability of a gene to repress its own synthesis, is the most abundant regulatory motif known to biology. Frequently reported for transcriptional regulators, negative feedback control relies on bindi…
View article: Data and scripts for Hoyos et al. 2020 - Gene autoregulation at the RNA level
Data and scripts for Hoyos et al. 2020 - Gene autoregulation at the RNA level Open
Data and script for Hoyos et al., 2020 - "Gene autoregulation by 3’ UTR-derived bacterial small RNAs" (https://doi.org/10.7554/eLife.58836).
View article: Data and scripts for Hoyos et al. 2020 - Gene autoregulation at the RNA level
Data and scripts for Hoyos et al. 2020 - Gene autoregulation at the RNA level Open
Data and script for Hoyos et al. 2020 - "Gene autoregulation at the RNA level".
View article: Switching fatty acid metabolism by an RNA-controlled feed forward loop
Switching fatty acid metabolism by an RNA-controlled feed forward loop Open
Hfq (host factor for phage Q beta) is key for posttranscriptional gene regulation in many bacteria. Hfq’s function is to stabilize sRNAs and to facilitate base-pairing with trans -encoded target mRNAs. Loss of Hfq typically results in plei…
View article: Optically tracked and 3D printed haptic phantom hand for surgical training system
Optically tracked and 3D printed haptic phantom hand for surgical training system Open
In this work, an optically tracked and haptically correct phantom hand was developed using dual-material 3D printing, which can be easily integrated into a surgical training system.
View article: Quantitative Analysis of Surface Contouring with Pulsed Bipolar Radiofrequency on Thin Chondromalacic Cartilage
Quantitative Analysis of Surface Contouring with Pulsed Bipolar Radiofrequency on Thin Chondromalacic Cartilage Open
The purpose of this study was to evaluate the quality of surface contouring of chondromalacic cartilage by bipolar radio frequency energy using different treatment patterns in an animal model, as well as examining the impact of the treatme…
View article: CORR Insights®: What is the Natural History of the Triangular Fibrocartilage Complex Tear Without Distal Radioulnar Joint Instability?
CORR Insights®: What is the Natural History of the Triangular Fibrocartilage Complex Tear Without Distal Radioulnar Joint Instability? Open
Where Are We Now? Ulnar-sided wrist pain is a common problem; nearly 30 pathological and pathoanatomical entities may cause or contribute to it. While some can be easily identified, others, like lunotriquetral ligament injury, are much mor…
View article: Imitating human soft tissue on basis of a dual-material 3D print using a support-filled metamaterial to provide bimanual haptic for a hand surgery training system
Imitating human soft tissue on basis of a dual-material 3D print using a support-filled metamaterial to provide bimanual haptic for a hand surgery training system Open
We developed a new dual-material 3D print technique to imitate soft tissue of the human hand with its haptic properties. Blowy SUP is trapped within a lattice structure to soften rubber-like 3D print material, which makes it possible to re…
View article: Leukocyte-Reduced Platelet-Rich Plasma Treatment of Basal Thumb Arthritis: A Pilot Study
Leukocyte-Reduced Platelet-Rich Plasma Treatment of Basal Thumb Arthritis: A Pilot Study Open
A positive effect of intra-articular platelet-rich plasma (PRP) injection has been discussed for osteoarthritic joint conditions in the last years. The purpose of this study was to evaluate PRP injection into the trapeziometacarpal (TMC) j…