Michaela Jacobs
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View article: Uridine Bisphosphonates Differentiate Phosphoglycosyl Transferase Superfamilies
Uridine Bisphosphonates Differentiate Phosphoglycosyl Transferase Superfamilies Open
Complex bacterial glycoconjugates drive interactions between pathogens, symbionts, and their human hosts. Glycoconjugate biosynthesis is initiated at the membrane interface by phosphoglycosyl transferases (PGTs), which catalyze the transfe…
View article: Uridine Bisphosphonates Differentiate Phosphoglycosyl Transferase Superfamilies
Uridine Bisphosphonates Differentiate Phosphoglycosyl Transferase Superfamilies Open
Complex bacterial glycoconjugates are essential for bacterial survival, and drive interactions between pathogens and symbionts, and their human hosts. Glycoconjugate biosynthesis is initiated at the membrane interface by phosphoglycosyl tr…
View article: Synthesis and anti-cancer potential of potent peripheral MAOA inhibitors designed to limit blood:brain penetration
Synthesis and anti-cancer potential of potent peripheral MAOA inhibitors designed to limit blood:brain penetration Open
Monoamine oxidases (MAOA/MAOB) are enzymes known for their role in neurotransmitter regulation in the central nervous system (CNS). Irreversible and non-selective MAO inhibitors (MAOi's) were the first class of antidepressants, thus subseq…
View article: Production of Butyrate and Branched Chain Amino Acid Catabolic Byproducts by CHO Cells in Fed-batch Culture Enhances their Specific Productivity
Production of Butyrate and Branched Chain Amino Acid Catabolic Byproducts by CHO Cells in Fed-batch Culture Enhances their Specific Productivity Open
Chinese hamster ovary (CHO) cells in fed-batch cultures produce several metabolic byproducts derived from amino acid catabolism, some of which accumulate to growth inhibitory levels. Controlling the accumulation of these byproducts has bee…