Michaela Jeong
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View article: Development of Lipid Nanoparticle Formulation for the Repeated Administration of mRNA Therapeutics
Development of Lipid Nanoparticle Formulation for the Repeated Administration of mRNA Therapeutics Open
During the COVID-19 pandemic, mRNA vaccines emerged as a rapid and effective solution for global immunization. The success of COVID-19 mRNA vaccines has increased interest in the use of lipid nanoparticles (LNPs) for the in vivo delivery o…
View article: Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics
Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics Open
Several studies have utilized a lipid nanoparticle delivery system to enhance the effectiveness of mRNA therapeutics and vaccines. However, these nanoparticles are recognized as foreign materials by the body and stimulate innate immunity, …
View article: Novel piperazine‐based ionizable lipid nanoparticles allow the repeated dose of mRNA to fibrotic lungs with improved potency and safety
Novel piperazine‐based ionizable lipid nanoparticles allow the repeated dose of mRNA to fibrotic lungs with improved potency and safety Open
mRNA‐based protein replacement therapy has received much attention as a novel intervention in clinical disease treatment. Lipid nanoparticles (LNPs) are widely used for their therapeutic potential to efficiently deliver mRNA. However, clin…
View article: In vivo delivery of CRISPR-Cas9 using lipid nanoparticles enables antithrombin gene editing for sustainable hemophilia A and B therapy
In vivo delivery of CRISPR-Cas9 using lipid nanoparticles enables antithrombin gene editing for sustainable hemophilia A and B therapy Open
Hemophilia is a hereditary disease that remains incurable. Although innovative treatments such as gene therapy or bispecific antibody therapy have been introduced, substantial unmet needs still exist with respect to achieving long-lasting …
View article: Engineered ionizable lipid nanoparticles for targeted delivery of RNA therapeutics into different types of cells in the liver
Engineered ionizable lipid nanoparticles for targeted delivery of RNA therapeutics into different types of cells in the liver Open
Engineered ionizable lipid nanoparticles (LNPs) were developed for the LSEC-specific delivery of RNA therapeutics.