Michaela Jung
YOU?
Author Swipe
View article: The Macrophage Iron Signature in Health and Disease
The Macrophage Iron Signature in Health and Disease Open
Throughout life, macrophages are located in every tissue of the body, where their main roles are to phagocytose cellular debris and recycle aging red blood cells. In the tissue niche, they promote homeostasis through trophic, regulatory, a…
View article: Core Cross‐Linked Polymeric Micelles for Specific Iron Delivery: Inducing Sterile Inflammation in Macrophages
Core Cross‐Linked Polymeric Micelles for Specific Iron Delivery: Inducing Sterile Inflammation in Macrophages Open
Iron is an essential co‐factor for cellular processes. In the immune system, it can activate macrophages and represents a potential therapeutic for various diseases. To specifically deliver iron to macrophages, iron oxide nanoparticles are…
View article: Iron-Bound Lipocalin-2 Protects Renal Cell Carcinoma from Ferroptosis
Iron-Bound Lipocalin-2 Protects Renal Cell Carcinoma from Ferroptosis Open
While the importance of the iron-load of lipocalin-2 (Lcn-2) in promoting tumor progression is widely appreciated, underlying molecular mechanisms largely remain elusive. Considering its role as an iron-transporter, we aimed at clarifying …
View article: Iron-Bound Lipocalin-2 from Tumor-Associated Macrophages Drives Breast Cancer Progression Independent of Ferroportin
Iron-Bound Lipocalin-2 from Tumor-Associated Macrophages Drives Breast Cancer Progression Independent of Ferroportin Open
Macrophages supply iron to the breast tumor microenvironment by enforced secretion of lipocalin-2 (Lcn-2)-bound iron as well as the increased expression of the iron exporter ferroportin (FPN). We aimed at identifying the contribution of ea…
View article: Macrophage-Derived Iron-Bound Lipocalin-2 Correlates with Renal Recovery Markers Following Sepsis-Induced Kidney Damage
Macrophage-Derived Iron-Bound Lipocalin-2 Correlates with Renal Recovery Markers Following Sepsis-Induced Kidney Damage Open
During the course of sepsis in critically ill patients, kidney dysfunction and damage are among the first events of a complex scenario toward multi-organ failure and patient death. Acute kidney injury triggers the release of lipocalin-2 (L…
View article: Macrophage-Secreted Lipocalin-2 Promotes Regeneration of Injured Primary Murine Renal Tubular Epithelial Cells
Macrophage-Secreted Lipocalin-2 Promotes Regeneration of Injured Primary Murine Renal Tubular Epithelial Cells Open
Lipocalin-2 (Lcn-2) is rapidly upregulated in macrophages after renal tubular injury and acts as renoprotective and pro-regenerative agent. Lcn-2 possesses the ability to bind and transport iron with high affinity. Therefore, the present s…
View article: The Disturbed Iron Phenotype of Tumor Cells and Macrophages in Renal Cell Carcinoma Influences Tumor Growth
The Disturbed Iron Phenotype of Tumor Cells and Macrophages in Renal Cell Carcinoma Influences Tumor Growth Open
Accumulating evidence suggests that iron homeostasis is disturbed in tumors. We aimed at clarifying the distribution of iron in renal cell carcinoma (RCC). Considering the pivotal role of macrophages for iron homeostasis and their associat…
View article: Strategies to Interfere with Tumor Metabolism through the Interplay of Innate and Adaptive Immunity
Strategies to Interfere with Tumor Metabolism through the Interplay of Innate and Adaptive Immunity Open
The inflammatory tumor microenvironment is an important regulator of carcinogenesis. Tumor-infiltrating immune cells promote each step of tumor development, exerting crucial functions from initiation, early neovascularization, to metastasi…
View article: Iron as a Central Player and Promising Target in Cancer Progression
Iron as a Central Player and Promising Target in Cancer Progression Open
Iron is an essential element for virtually all organisms. On the one hand, it facilitates cell proliferation and growth. On the other hand, iron may be detrimental due to its redox abilities, thereby contributing to free radical formation,…
View article: Macrophages attenuate the transcription of CYP1A1 in breast tumor cells and enhance their proliferation
Macrophages attenuate the transcription of CYP1A1 in breast tumor cells and enhance their proliferation Open
While aberrant cells are routinely recognized and removed by immune cells, tumors eventually escape innate immune responses. Infiltrating immune cells are even corrupted by the tumor to acquire a tumor-supporting phenotype. In line, tumor-…
View article: The Fibrin Cleavage Product Bβ15-42 Channels Endothelial and Tubular Regeneration in the Post-acute Course During Murine Renal Ischemia Reperfusion Injury
The Fibrin Cleavage Product Bβ15-42 Channels Endothelial and Tubular Regeneration in the Post-acute Course During Murine Renal Ischemia Reperfusion Injury Open
Early and adequate restoration of endothelial and tubular renal function is a substantial step during regeneration after ischemia reperfusion (IR) injury, occurring, e.g., in kidney transplantation, renal surgery, and sepsis. While tubular…
View article: Macrophage-derived lipocalin-2 transports iron in the tumor microenvironment
Macrophage-derived lipocalin-2 transports iron in the tumor microenvironment Open
While the importance of iron for tumor development is widely appreciated, the exact sources of tumor-supporting iron largely remain elusive. The possibility that iron might be provided by stromal cells in the tumor microenvironment was not…
View article: Iron Handling in Tumor-Associated Macrophages—Is There a New Role for Lipocalin-2?
Iron Handling in Tumor-Associated Macrophages—Is There a New Role for Lipocalin-2? Open
Carcinogenesis is a multistep process. Besides somatic mutations in tumor cells, stroma-associated immunity is a major regulator of tumor growth. Tumor cells produce and secrete diverse mediators to create a local microenvironment that sup…
View article: S1P Provokes Tumor Lymphangiogenesis via Macrophage-Derived Mediators Such as IL-1<i>β</i>or Lipocalin-2
S1P Provokes Tumor Lymphangiogenesis via Macrophage-Derived Mediators Such as IL-1<i>β</i>or Lipocalin-2 Open
A pleiotropic signaling lipid, sphingosine-1-phosphate (S1P), has been implicated in various pathophysiological processes supporting tumor growth and metastasis. However, there are only a few descriptive studies suggesting a role of S1P in…
View article: Intracellular Iron Chelation Modulates the Macrophage Iron Phenotype with Consequences on Tumor Progression
Intracellular Iron Chelation Modulates the Macrophage Iron Phenotype with Consequences on Tumor Progression Open
A growing body of evidence suggests that macrophage polarization dictates the expression of iron-regulated genes. Polarization towards iron sequestration depletes the microenvironment, whereby extracellular pathogen growth is limited and i…
View article: Tumour stroma‐derived lipocalin‐2 promotes breast cancer metastasis
Tumour stroma‐derived lipocalin‐2 promotes breast cancer metastasis Open
Tumour cell‐secreted factors skew infiltrating immune cells towards a tumour‐supporting phenotype, expressing pro‐tumourigenic mediators. However, the influence of lipocalin‐2 (Lcn2) on the metastatic cascade in the tumour micro‐environmen…
View article: Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses
Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses Open
Different modes of cell death regulate immunity. Whereas necrotic (necroptotic, pyroptotic) cell death triggers inflammation, apoptosis contributes to its resolution. Interleukin-1 (IL-1) family cytokines are key players in this interactio…