Michaela Schweizer
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View article: Lehr‐Lern‐Materialien für den Chemieunterricht – Wie groß ist der webbasierte Möglichkeitsraum zur Gestaltung von Unterrichtsangeboten? Eine Sichtung webbasierter Lehr‐Lernangebote
Lehr‐Lern‐Materialien für den Chemieunterricht – Wie groß ist der webbasierte Möglichkeitsraum zur Gestaltung von Unterrichtsangeboten? Eine Sichtung webbasierter Lehr‐Lernangebote Open
Das Internet stellt einen wachsenden Möglichkeitsraum zur Gestaltung von Lernangeboten dar. Über die letzten Jahre sind eine Vielzahl Unterrichtsmaterialien entwickelt und zugänglich gemacht worden. Dieser Artikel beschreibt eine an das PR…
View article: Extracellular Vesicles Released From Cortical Neurons Influence Spontaneous Activity of Recipient Neurons
Extracellular Vesicles Released From Cortical Neurons Influence Spontaneous Activity of Recipient Neurons Open
Extracellular vesicles (EVs) are membranous structures that cells release into the extracellular space. EVs carry various molecules such as proteins, lipids, and nucleic acids, and serve as specialized transporters to influence other cells…
View article: Ultrastructural analysis of synapses after induction of spike-timing-dependent plasticity
Ultrastructural analysis of synapses after induction of spike-timing-dependent plasticity Open
Repeated sequential activation of connected neurons causes lasting changes in synaptic strength, a process known as spike-timing-dependent plasticity (STDP). Recently, sequential spike patterns have been induced without electrodes, using t…
View article: Pathological meprin α expression associated with degradation of dermokine drives a psoriasis-like skin phenotype in a genetic mouse model
Pathological meprin α expression associated with degradation of dermokine drives a psoriasis-like skin phenotype in a genetic mouse model Open
Keratinocyte proliferation and differentiation is regulated via proteolytic networks. Dysregulation of proteases within these networks can cause hyperproliferative and inflammatory skin disorders. In healthy skin the metalloprotease meprin…
View article: The Molecular Architecture of Somatic Spines of the Lateral Septum
The Molecular Architecture of Somatic Spines of the Lateral Septum Open
The lateral septum is a key subcortical structure and has been implicated in kinship memory. Across species, the ability to recognise relatives is conserved and is reflected in stable, lifelong memories. The molecular mechanisms underlying…
View article: Extracellular vesicles released from cortical neurons influence spontaneous activity of recipient neurons.
Extracellular vesicles released from cortical neurons influence spontaneous activity of recipient neurons. Open
Extracellular vesicles (EVs) are membranous structures that cells release into the extracellular space. EVs carry various molecules such as proteins, lipids, and nucleic acids, and serve as specialized transporters to influence other cells…
View article: GOLPH3 and GOLPH3L maintain Golgi localization of LYSET and a functional mannose 6-phosphate transport pathway
GOLPH3 and GOLPH3L maintain Golgi localization of LYSET and a functional mannose 6-phosphate transport pathway Open
Glycosylation, which plays an important role in modifying lipids and sorting of proteins, is regulated by asymmetric intra-Golgi distribution and SPPL3-mediated cleavage of Golgi enzymes. We found that cells lacking LYSET/TMEM251, a retent…
View article: Efficient enzyme‐free isolation of brain‐derived extracellular vesicles
Efficient enzyme‐free isolation of brain‐derived extracellular vesicles Open
Extracellular vesicles (EVs) have gained significant attention as pathology mediators and potential diagnostic tools for neurodegenerative diseases. However, isolation of brain‐derived EVs (BDEVs) from tissue remains challenging, often inv…
View article: Bone-seeking tumor cells alter bone material quality parameters on the nanoscale in mice
Bone-seeking tumor cells alter bone material quality parameters on the nanoscale in mice Open
Bone metastases related to breast and prostate cancer present with multiple challenges and skeletal related events like fragility fractures impair the quality of life of the patients significantly. To determine local alterations in bone ma…
View article: Severe mpox in an immunocompromised patient complicated by deep tissue infection: A case report
Severe mpox in an immunocompromised patient complicated by deep tissue infection: A case report Open
Our data provide evidence that Tecovirimat treatment selects for compartimentalized viral mutations (A288P). While the patient clinically benefited from repeated tecovirimat course, emergence of viral muations and deep tissue infection emp…
View article: PITX2 deficiency leads to atrial mitochondrial dysfunction
PITX2 deficiency leads to atrial mitochondrial dysfunction Open
Aims Reduced left atrial PITX2 is associated with atrial cardiomyopathy and atrial fibrillation (AF). PITX2 is restricted to left atrial cardiomyocytes (aCMs) in the adult heart. The links between PITX2 deficiency, atrial cardiomyopathy, a…
View article: TRPML1 activation ameliorates lysosomal phenotypes in CLN3 deficient retinal pigment epithelial cells
TRPML1 activation ameliorates lysosomal phenotypes in CLN3 deficient retinal pigment epithelial cells Open
Mutations in the lysosomal membrane protein CLN3 cause Juvenile Neuronal Ceroid Lipofuscinosis (JNCL). Activation of the lysosomal ion channel TRPML1 has previously been shown to be beneficial in several neurodegenerative disease models. H…
View article: Inefficient tissue immune response against MPXV in an immunocompromised mpox patient
Inefficient tissue immune response against MPXV in an immunocompromised mpox patient Open
The recent outbreak of monkeypox virus (MPXV) was unprecedented in its size and distribution. Those living with uncontrolled HIV and low CD4 T cell counts might develop a fulminant clinical mpox course with increased mortality, secondary i…
View article: Inter-alpha-trypsin inhibitor heavy chain H3 is a potential biomarker for disease activity in myasthenia gravis
Inter-alpha-trypsin inhibitor heavy chain H3 is a potential biomarker for disease activity in myasthenia gravis Open
Myasthenia gravis is a chronic antibody-mediated autoimmune disease disrupting neuromuscular synaptic transmission. Informative biomarkers remain an unmet need to stratify patients with active disease requiring intensified monitoring and t…
View article: Cystatin C loaded in brain-derived extracellular vesicles rescues synapses after ischemic insult in vitro and in vivo
Cystatin C loaded in brain-derived extracellular vesicles rescues synapses after ischemic insult in vitro and in vivo Open
Synaptic loss is an early event in the penumbra area after an ischemic stroke. Promoting synaptic preservation in this area would likely improve functional neurological recovery. We aimed to detect proteins involved in endogenous protectio…
View article: Non-canonical function of ADAM10 in presynaptic plasticity
Non-canonical function of ADAM10 in presynaptic plasticity Open
A Disintegrin And Metalloproteinase 10 (ADAM10) plays a pivotal role in shaping neuronal networks by orchestrating the activity of numerous membrane proteins through the shedding of their extracellular domains. Despite its significance in …
View article: Astrocytic uptake of posttranslationally modified amyloid‐β leads to endolysosomal system disruption and induction of pro‐inflammatory signaling
Astrocytic uptake of posttranslationally modified amyloid‐β leads to endolysosomal system disruption and induction of pro‐inflammatory signaling Open
The disruption of astrocytic catabolic processes contributes to the impairment of amyloid‐β (Aβ) clearance, neuroinflammatory signaling, and the loss of synaptic contacts in late‐onset Alzheimer's disease (AD). While it is known that the p…
View article: Efficient enzyme-free isolation of brain-derived extracellular vesicles
Efficient enzyme-free isolation of brain-derived extracellular vesicles Open
Extracellular vesicles (EVs) have gained significant attention as pathology mediators and potential diagnostic tools for neurodegenerative diseases. However, isolation of brain-derived EVs (BDEVs) from tissue remains challenging, often inv…
View article: Functional Inhibition of Katanin Affects Synaptic Plasticity
Functional Inhibition of Katanin Affects Synaptic Plasticity Open
Dynamic microtubules critically regulate synaptic functions, but the role of microtubule severing in these processes is barely understood. Katanin is a neuronally expressed microtubule-severing complex regulating microtubule number and len…
View article: Human model of primary carnitine deficiency cardiomyopathy reveals ferroptosis as a novel mechanism
Human model of primary carnitine deficiency cardiomyopathy reveals ferroptosis as a novel mechanism Open
Primary carnitine deficiency (PCD) is an autosomal recessive monogenic disorder caused by mutations in SLC22A5. This gene encodes for OCTN2, which transports the essential metabolite carnitine into the cell. PCD patients suffer from muscul…
View article: Astrocytic uptake of posttranslationally modified amyloid-β leads to endolysosomal system disruption and induction of pro-inflammatory signaling
Astrocytic uptake of posttranslationally modified amyloid-β leads to endolysosomal system disruption and induction of pro-inflammatory signaling Open
The disruption of astrocytic catabolic processes contributes to the impairment of amyloid-β (Aβ) clearance, neuroinflammatory signaling, and the loss of synaptic contacts in late-onset Alzheimer’s disease (AD). While it is known that the p…
View article: Tetraspanin 15 depletion impairs extracellular vesicle docking at target neurons
Tetraspanin 15 depletion impairs extracellular vesicle docking at target neurons Open
Neurons in the central nervous system release extracellular vesicles (EVs) and exosomes in response to synaptic activity to regulate physiological processes at target neurons. The intercellular transfer of proteins, mRNAs, lipids or metabo…
View article: The kinesin Kif21b binds myosin Va and mediates changes in actin dynamics underlying homeostatic synaptic downscaling
The kinesin Kif21b binds myosin Va and mediates changes in actin dynamics underlying homeostatic synaptic downscaling Open
Summary: Homeostatic synaptic plasticity adjusts the strength of synapses to restrain neuronal activity within a physiological range. Postsynaptic guanylate kinase-associated protein (GKAP) controls the bidirectional synaptic scaling of AM…
View article: TRPML1 activation ameliorates lysosomal phenotypes in CLN3 deficient retinal pigment epithelial cells
TRPML1 activation ameliorates lysosomal phenotypes in CLN3 deficient retinal pigment epithelial cells Open
Mutations in the lysosomal membrane protein CLN3 cause Juvenile Neuronal Ceroid Lipofuscinosis (JNCL). Activation of the lysosomal ion channel TRPML1 has previously been shown to be beneficial in several neurodegenerative disease models. H…