Michaela Šiková
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View article: Expanding the CarD interaction network: CrsL is a novel transcription factor in<i>Mycobacterium smegmatis</i>
Expanding the CarD interaction network: CrsL is a novel transcription factor in<i>Mycobacterium smegmatis</i> Open
Bacterial transcription regulation is critical for adaptation and survival. CarD is an essential transcription factor in mycobacteria involved in regulation of gene expression. We searched for CarD interaction partners in the model organis…
View article: HelD is a Global Transcription Factor Enhancing Gene Expression in Rapidly Growing Mycobacteria
HelD is a Global Transcription Factor Enhancing Gene Expression in Rapidly Growing Mycobacteria Open
HelD protein, also named HelR (encoded by MSMEG_2174 in Mycobacterium smegmatis ), interacts with mycobacterial RNA polymerase (RNAP) and affects rifampicin resistance in Mycobacterium abscessus . Here, we provide data on rifampicin resist…
View article: MoaB2, a newly identified transcription factor, binds to σ <sup>A</sup> in <i>Mycobacterium smegmatis</i>
MoaB2, a newly identified transcription factor, binds to σ <sup>A</sup> in <i>Mycobacterium smegmatis</i> Open
In mycobacteria, σ A is the primary sigma factor. This essential protein binds to RNA polymerase (RNAP) and mediates transcription initiation of housekeeping genes. Our knowledge about this factor in mycobacteria is limited. Here, we perfo…
View article: RIP-seq reveals RNAs that interact with RNA polymerase and primary sigma factors in bacteria
RIP-seq reveals RNAs that interact with RNA polymerase and primary sigma factors in bacteria Open
Bacteria have evolved structured RNAs that can associate with RNA polymerase (RNAP). Two of them have been known so far—6S RNA and Ms1 RNA but it is unclear if any other types of RNAs binding to RNAP exist in bacteria. To identify all RNAs…
View article: Ms1 RNA Interacts With the RNA Polymerase Core in Streptomyces coelicolor and Was Identified in Majority of Actinobacteria Using a Linguistic Gene Synteny Search
Ms1 RNA Interacts With the RNA Polymerase Core in Streptomyces coelicolor and Was Identified in Majority of Actinobacteria Using a Linguistic Gene Synteny Search Open
Bacteria employ small non-coding RNAs (sRNAs) to regulate gene expression. Ms1 is an sRNA that binds to the RNA polymerase (RNAP) core and affects the intracellular level of this essential enzyme. Ms1 is structurally related to 6S RNA that…
View article: Deciphering the role of unique bacterial transcription-associated factor HelD
Deciphering the role of unique bacterial transcription-associated factor HelD Open
Bacterial RNA polymerase (RNAP) is an essential multisubunit enzyme performing transcription.Regulation of this process is secured through the stage-dependent interactions of RNAP with different factors (mostly proteins).Here we report the…
View article: Mycobacterial HelD is a nucleic acids-clearing factor for RNA polymerase
Mycobacterial HelD is a nucleic acids-clearing factor for RNA polymerase Open
RNA synthesis is central to life, and RNA polymerase (RNAP) depends on accessory factors for recovery from stalled states and adaptation to environmental changes. Here, we investigated the mechanism by which a helicase-like factor HelD rec…
View article: Author Correction: Bacterial nanotubes as a manifestation of cell death
Author Correction: Bacterial nanotubes as a manifestation of cell death Open
View article: Bacterial nanotubes as a manifestation of cell death
Bacterial nanotubes as a manifestation of cell death Open
View article: Data and statistical analysis for: Bacterial nanotubes are a manifestation of cell death
Data and statistical analysis for: Bacterial nanotubes are a manifestation of cell death Open
Contains all data and code to reproduce the statistical analysis in the Supplementary file 2 for the paper "Bacterial nanotubes are a manifestation of cell death" to be published in Nature Communications. Contents: statist…
View article: Data and statistical analysis for: Bacterial nanotubes are a manifestation of cell death
Data and statistical analysis for: Bacterial nanotubes are a manifestation of cell death Open
Contains all data and code to reproduce the statistical analysis in the Supplementary file 2 for the paper "Bacterial nanotubes are a manifestation of cell death" to be published in Nature Communications. Contents: statist…
View article: Data and statistical analysis for: Bacterial nanotubes are a manifestation of cell death
Data and statistical analysis for: Bacterial nanotubes are a manifestation of cell death Open
Contains all data and code to reproduce the statistical analysis in the Supplementary file 2 for the paper "Bacterial nanotubes are a manifestation of cell death" to be published in Nature Communications. Contents: statis…
View article: Data and statistical analysis for: Bacterial nanotubes are a manifestation of cell death
Data and statistical analysis for: Bacterial nanotubes are a manifestation of cell death Open
Contains all data and code to reproduce the statistical analysis in the Supplementary file 2 for the paper "Bacterial nanotubes are a manifestation of cell death" to be published in Nature Communications. Contents: statis…
View article: Mycobacterial HelD is a nucleic acids-clearing factor for RNA polymerase
Mycobacterial HelD is a nucleic acids-clearing factor for RNA polymerase Open
SUMMARY RNA synthesis is central to life, and RNA polymerase depends on accessory factors for recovery from stalled states and adaption to environmental changes. Here we investigated the mechanism by which a helicase-like factor HelD recyc…
View article: The torpedo effect in<i>Bacillus subtilis</i>:<scp>RN</scp>ase J1 resolves stalled transcription complexes
The torpedo effect in<i>Bacillus subtilis</i>:<span>RN</span>ase J1 resolves stalled transcription complexes Open
View article: Ms1 RNA increases the amount of RNA polymerase in <i>Mycobacterium smegmatis</i>
Ms1 RNA increases the amount of RNA polymerase in <i>Mycobacterium smegmatis</i> Open
Summary Ms1 is a sRNA recently found in mycobacteria and several other actinobacterial species. Ms1 interacts with the RNA polymerase (RNAP) core devoid of sigma factors, which differs from 6S RNA that binds to RNAP holoenzymes containing …
View article: Insights into the Mechanism of Action of Bactericidal Lipophosphonoxins
Insights into the Mechanism of Action of Bactericidal Lipophosphonoxins Open
The advantages offered by established antibiotics in the treatment of infectious diseases are endangered due to the increase in the number of antibiotic-resistant bacterial strains. This leads to a need for new antibacterial compounds. Rec…