Michaela Zwyer
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View article: Variability in intrinsic drug tolerance in <i>Mycobacterium tuberculosis</i> corresponds with phylogenetic lineage
Variability in intrinsic drug tolerance in <i>Mycobacterium tuberculosis</i> corresponds with phylogenetic lineage Open
Drug tolerance allows bacteria to survive extended exposure to bactericidal drugs and is thought to play a role in drug resistance evolution. In Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), multidrug-resistan…
View article: Mycobacterium tuberculosis complex Lineage 1: A neglected cause of tuberculosis
Mycobacterium tuberculosis complex Lineage 1: A neglected cause of tuberculosis Open
The Mycobacterium tuberculosis complex (MTBC) phylogenetic lineages 1–4 (L1–L4) are the main causes of human tuberculosis (TB). Until now, most of the focus in the TB field has been on MTBC L2 and L4, as these two lineages are geographical…
View article: Assessment of different techniques and markers to distinguish recrudescence from new infection in an antimalarial therapeutic efficacy study conducted in Rwanda
Assessment of different techniques and markers to distinguish recrudescence from new infection in an antimalarial therapeutic efficacy study conducted in Rwanda Open
Introduction Accurate estimation of antimalarial drug efficacy against P. falciparum requires PCR correction to distinguish recrudescence from new infection in recurrent infections. Genotyping length polymorphic or SNP-rich markers, and va…
View article: Human genetic ancestry, Mycobacterium tuberculosis diversity and tuberculosis disease severity in Dar es Salaam, Tanzania
Human genetic ancestry, Mycobacterium tuberculosis diversity and tuberculosis disease severity in Dar es Salaam, Tanzania Open
Infectious diseases have affected humanity for millennia and are among the strongest selective forces. Tuberculosis (TB) is an ancient disease, caused by the human-adapted members of the Mycobacterium tuberculosis complex (MTBC). The outco…
View article: Author response: Human genetic ancestry, Mycobacterium tuberculosis diversity and tuberculosis disease severity in Dar es Salaam, Tanzania
Author response: Human genetic ancestry, Mycobacterium tuberculosis diversity and tuberculosis disease severity in Dar es Salaam, Tanzania Open
View article: Variability in intrinsic drug tolerance in <i>Mycobacterium tuberculosis</i> corresponds with phylogenetic lineage
Variability in intrinsic drug tolerance in <i>Mycobacterium tuberculosis</i> corresponds with phylogenetic lineage Open
Drug tolerance allows bacteria to survive extended exposure to bactericidal drugs and is thought to play a role in drug resistance evolution. In Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), multidrug resistan…
View article: Genome-to-genome analysis reveals associations between human and mycobacterial genetic variation in tuberculosis patients from Tanzania
Genome-to-genome analysis reveals associations between human and mycobacterial genetic variation in tuberculosis patients from Tanzania Open
View article: Onset of infectiousness explains differences in transmissibility across Mycobacterium tuberculosis lineages
Onset of infectiousness explains differences in transmissibility across Mycobacterium tuberculosis lineages Open
View article: Human genetic ancestry, Mycobacterium tuberculosis diversity and tuberculosis disease severity in Dar es Salaam, Tanzania
Human genetic ancestry, Mycobacterium tuberculosis diversity and tuberculosis disease severity in Dar es Salaam, Tanzania Open
Infectious diseases have affected humanity for millennia and are among the strongest selective forces. Tuberculosis (TB) is an ancient disease, caused by the human-adapted members of the Mycobacterium tuberculosis complex (MTBC). The outco…
View article: Human genetic ancestry, Mycobacterium tuberculosis diversity and tuberculosis disease severity in Dar es Salaam, Tanzania
Human genetic ancestry, Mycobacterium tuberculosis diversity and tuberculosis disease severity in Dar es Salaam, Tanzania Open
Infectious diseases have affected humanity for millennia and are among the strongest selective forces. Tuberculosis (TB) is an ancient disease, caused by the human-adapted members of the Mycobacterium tuberculosis complex (MTBC). The outco…
View article: Onset of infectiousness explains differences in transmissibility across<i>Mycobacterium tuberculosis</i>lineages
Onset of infectiousness explains differences in transmissibility across<i>Mycobacterium tuberculosis</i>lineages Open
Mycobacterium tuberculosis complex (MTBC) lineages show substantial variability in virulence, but the epidemiological consequences of this variability have not been studied in detail. Here, we aimed for a lineage-specific epidemiological c…
View article: Human genetic ancestry, <i>Mycobacterium tuberculosis</i> diversity and tuberculosis disease severity in Dar es Salaam, Tanzania
Human genetic ancestry, <i>Mycobacterium tuberculosis</i> diversity and tuberculosis disease severity in Dar es Salaam, Tanzania Open
Infectious diseases have affected humanity for millennia and are among the strongest selective forces. Tuberculosis (TB) is an ancient disease, caused by the human-adapted members of the Mycobacterium tuberculosis complex (MTBC). The outco…
View article: Bacterial diversity dominates variable macrophage responses of tuberculosis patients in Tanzania
Bacterial diversity dominates variable macrophage responses of tuberculosis patients in Tanzania Open
View article: Bacterial diversity dominates variable macrophage responses of tuberculosis patients in Tanzania
Bacterial diversity dominates variable macrophage responses of tuberculosis patients in Tanzania Open
The Mycobacterium tuberculosis complex (MTBC) comprises nine human-adapted lineages that differ in their geographical distribution. Local adaptation of specific MTBC genotypes to the respective human host population has been invoked in thi…
View article: Genome-to-genome analysis reveals associations between human and mycobacterial genetic variation in tuberculosis patients from Tanzania
Genome-to-genome analysis reveals associations between human and mycobacterial genetic variation in tuberculosis patients from Tanzania Open
The risk and prognosis of tuberculosis (TB) are affected by both human and bacterial genetic factors. To identify interacting human and bacterial genetic loci, we leveraged paired human and Mycobacterium tuberculosis ( M . tb ) genomic dat…
View article: Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania
Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania Open
In settings with high tuberculosis (TB) endemicity, distinct genotypes of the Mycobacterium tuberculosis complex (MTBC) often differ in prevalence. However, the factors leading to these differences remain poorly understood. Here we studied…
View article: Back-to-Africa introductions of <i>Mycobacterium tuberculosis</i> as the main cause of tuberculosis in Dar es Salaam, Tanzania
Back-to-Africa introductions of <i>Mycobacterium tuberculosis</i> as the main cause of tuberculosis in Dar es Salaam, Tanzania Open
In settings with high tuberculosis (TB) endemicity, various genotypes of the Mycobacterium tuberculosis complex (MTBC) often differ in prevalence. However, the factors leading to these differences remain poorly understood. Here we studied …
View article: Using population-specific add-on polymorphisms to improve genotype imputation in underrepresented populations
Using population-specific add-on polymorphisms to improve genotype imputation in underrepresented populations Open
Genome-wide association studies rely on the statistical inference of untyped variants, called imputation, to increase the coverage of genotyping arrays. However, the results are often suboptimal in populations underrepresented in existing …
View article: A new nomenclature for the livestock-associated Mycobacterium tuberculosis complex based on phylogenomics
A new nomenclature for the livestock-associated Mycobacterium tuberculosis complex based on phylogenomics Open
Background: The bacteria that compose the Mycobacterium tuberculosis complex (MTBC) cause tuberculosis (TB) in humans and in different animals, including livestock. Much progress has been made in understanding the population structure of t…
View article: A new nomenclature for the livestock-associated Mycobacterium tuberculosis complex based on phylogenomics
A new nomenclature for the livestock-associated Mycobacterium tuberculosis complex based on phylogenomics Open
Background The bacteria that compose the Mycobacterium tuberculosis complex (MTBC) cause tuberculosis (TB) in humans and in different animals, including livestock. Much progress has been made in understanding the population structure of…
View article: Local adaptation in populations of Mycobacterium tuberculosis endemic to the Indian Ocean Rim
Local adaptation in populations of Mycobacterium tuberculosis endemic to the Indian Ocean Rim Open
Background: Lineage 1 (L1) and 3 (L3) are two lineages of the Mycobacterium tuberculosis complex (MTBC) causing tuberculosis (TB) in humans. L1 and L3 are prevalent around the rim of the Indian Ocean, the region that accounts for most of t…
View article: Using population-specific add-on polymorphisms to improve genotype imputation in underrepresented populations
Using population-specific add-on polymorphisms to improve genotype imputation in underrepresented populations Open
Genome-wide association studies rely on the statistical inference of untyped variants, called imputation, to increase the coverage of genotyping arrays. However, the results are often suboptimal in populations underrepresented in existing …
View article: Local adaptation in populations of Mycobacterium tuberculosis endemic to the Indian Ocean Rim
Local adaptation in populations of Mycobacterium tuberculosis endemic to the Indian Ocean Rim Open
Background: Lineage 1 (L1) and 3 (L3) are two lineages of the Mycobacterium tuberculosis complex (MTBC) causing tuberculosis (TB) in humans. L1 and L3 are prevalent around the rim of the Indian Ocean, the region that accounts for most of …
View article: Local adaptation in populations of<i>Mycobacterium tuberculosis</i>endemic to the Indian Ocean Rim
Local adaptation in populations of<i>Mycobacterium tuberculosis</i>endemic to the Indian Ocean Rim Open
Lineage 1 (L1) and 3 (L3) are two lineages of the Mycobacterium tuberculosis complex (MTBC), causing tuberculosis (TB) in humans. L1 and L3 are endemic to the Rim of the Indian Ocean, the region that accounts for most of the world’s new TB…
View article: Expression of a specific variant surface glycoprotein has a major impact on suramin sensitivity and endocytosis in <i>Trypanosoma brucei</i>
Expression of a specific variant surface glycoprotein has a major impact on suramin sensitivity and endocytosis in <i>Trypanosoma brucei</i> Open
Suramin was introduced into the clinic a century ago and is still used to treat the first stage of acute human sleeping sickness. Due to its size and sixfold negative charge, uptake is mediated through endocytosis and the suramin receptor …
View article: Beyond immune escape: a variant surface glycoprotein causes suramin resistance in <i>Trypanosoma brucei</i>
Beyond immune escape: a variant surface glycoprotein causes suramin resistance in <i>Trypanosoma brucei</i> Open
Summary Suramin is one of the first drugs developed in a medicinal chemistry program (Bayer, 1916), and it is still the treatment of choice for the hemolymphatic stage of African sleeping sickness caused by Trypanosoma brucei rhodesiense .…