Michal A. Elovitz
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View article: VIRGO2: an enhanced gene catalog of the vaginal microbiome provides insights into its functional and ecology complexity
VIRGO2: an enhanced gene catalog of the vaginal microbiome provides insights into its functional and ecology complexity Open
View article: Cervicovaginal microbiome alters transcriptomic and chromatin accessibility signatures across cervicovaginal epithelial barriers
Cervicovaginal microbiome alters transcriptomic and chromatin accessibility signatures across cervicovaginal epithelial barriers Open
These results provide new insights into host-microbe interactions within the lower reproductive tract and suggest that modulating the cervicovaginal microbiome could offer innovative therapeutic strategies to improve reproductive health. V…
View article: Mobiluncus mulieris alters the transcriptomic profile of cervicovaginal epithelial cells, shedding light on molecular drivers of adverse reproductive outcomes
Mobiluncus mulieris alters the transcriptomic profile of cervicovaginal epithelial cells, shedding light on molecular drivers of adverse reproductive outcomes Open
The vaginal microbiota is critical for reproductive health, and its disruption, particularly the loss of Lactobacillus spp. and dominance of anaerobes such as Mobiluncus mulieris (community state type IV, CST IV), is associated with bacter…
View article: Utility of the US Preventive Services Task Force for Preeclampsia Risk Assessment and Aspirin Prophylaxis
Utility of the US Preventive Services Task Force for Preeclampsia Risk Assessment and Aspirin Prophylaxis Open
Importance The US Preventive Services Task Force (USPSTF) guidelines on preeclampsia risk assessment and aspirin prophylaxis (AP) have not been evaluated for clinical utility. Objective To evaluate which characteristics in the USPSTF guide…
View article: Correction to: Clinician-reported childbirth outcomes, patient-reported childbirth trauma, and risk for postpartum depression
Correction to: Clinician-reported childbirth outcomes, patient-reported childbirth trauma, and risk for postpartum depression Open
View article: Cervicovaginal microbiome alters transcriptomic and epigenomic signatures across cervicovaginal epithelial barriers
Cervicovaginal microbiome alters transcriptomic and epigenomic signatures across cervicovaginal epithelial barriers Open
View article: Maternal Immune Activation During Pregnancy and Obstetric Outcomes: A Population‐Based Cohort Study
Maternal Immune Activation During Pregnancy and Obstetric Outcomes: A Population‐Based Cohort Study Open
Objective Maternal immune activation has been proposed as a mechanism for adverse pregnancy outcomes, yet the mechanisms and effects of timing remain unclear. Immune disruption in early gestation may be particularly detrimental as this is …
View article: Molecular subtyping of hypertensive disorders of pregnancy
Molecular subtyping of hypertensive disorders of pregnancy Open
View article: Mobiluncus mulieris Alters the Transcriptomic Profile of Cervicovaginal Epithelial Cells, Shedding Light on Molecular Drivers of Adverse Reproductive Outcomes
Mobiluncus mulieris Alters the Transcriptomic Profile of Cervicovaginal Epithelial Cells, Shedding Light on Molecular Drivers of Adverse Reproductive Outcomes Open
The vaginal microbiota plays a crucial role in reproductive health, with alterations in its composition linked to various adverse reproductive outcomes. These adverse outcomes are associated with vaginal microbiota characterized by the dep…
View article: VIRGO2: Unveiling the Functional and Ecological Complexity of the Vaginal Microbiome with an Enhanced Non-Redundant Gene Catalog
VIRGO2: Unveiling the Functional and Ecological Complexity of the Vaginal Microbiome with an Enhanced Non-Redundant Gene Catalog Open
Despite the importance of the cervicovaginal microbiome, the mechanisms that govern its composition and drive its impact on host physiology remain poorly understood. This study expands our understanding of the function and ecology of the v…
View article: Phenotyping Adolescent Endometriosis: Characterizing Symptom Heterogeneity Through Note- and Patient-Level Clustering
Phenotyping Adolescent Endometriosis: Characterizing Symptom Heterogeneity Through Note- and Patient-Level Clustering Open
Introduction Pelvic pain (dysmenorrhea and non-menstrual) is the most common presentation of adolescent endometriosis, but symptoms vary between and within patients. Other presentations, such as gastrointestinal (GI) symptoms, are often mi…
View article: Trajectories of mHealth-Tracked Mental Health and Their Predictors in Female Chronic Pelvic Pain Disorders
Trajectories of mHealth-Tracked Mental Health and Their Predictors in Female Chronic Pelvic Pain Disorders Open
These findings suggest that engaging in MVPA is beneficial to the mental health of females with CPPD. Additionally, this study demonstrates the potential of ambulatory mHealth-based data combined with functional models for delineating inte…
View article: Antibiotic exposure is associated with minimal gut microbiome perturbations in healthy term infants
Antibiotic exposure is associated with minimal gut microbiome perturbations in healthy term infants Open
Short-term and long-term gut microbiome perturbations by antibiotic exposure were detectable but substantially smaller than those associated with breastfeeding and infant age.
View article: Persistent Short Sleep Duration From Pregnancy to 2 to 7 Years After Delivery and Metabolic Health
Persistent Short Sleep Duration From Pregnancy to 2 to 7 Years After Delivery and Metabolic Health Open
Importance Short sleep duration during pregnancy and the perimenopausal period has been associated with adverse cardiometabolic outcomes. However, it remains unclear how sleep duration changes after delivery and whether such changes are as…
View article: Enhanced placental antibody transfer efficiency with longer interval between maternal respiratory syncytial virus vaccination and birth
Enhanced placental antibody transfer efficiency with longer interval between maternal respiratory syncytial virus vaccination and birth Open
View article: Longer interval between maternal RSV vaccination and birth increases placental transfer efficiency
Longer interval between maternal RSV vaccination and birth increases placental transfer efficiency Open
Background Respiratory Syncytial Virus (RSV) is associated with significant neonatal and infant morbidity and mortality. Maternal bivalent RSVpreF RSV vaccination to protect neonates and infants was approved in September 2023 for administr…
View article: Vaginal microbes alter epithelial transcriptome and induce epigenomic modifications providing insight into mechanisms for susceptibility to adverse reproductive outcomes
Vaginal microbes alter epithelial transcriptome and induce epigenomic modifications providing insight into mechanisms for susceptibility to adverse reproductive outcomes Open
The cervicovaginal microbiome is highly associated with women's health, with microbial communities dominated by Lactobacillus species considered optimal. Conversely, a lack of lactobacilli and a high abundance of strict and facultative ana…
View article: Extracellular vesicles from vaginal Gardnerella vaginalis and Mobiluncus mulieris contain distinct proteomic cargo and induce inflammatory pathways
Extracellular vesicles from vaginal Gardnerella vaginalis and Mobiluncus mulieris contain distinct proteomic cargo and induce inflammatory pathways Open
Summary Colonization of the vaginal space with bacteria such as Gardnerella vaginalis and Mobiluncus mulieris is associated with increased risk for STIs, bacterial vaginosis, and preterm birth, while Lactobacillus crispatus is associated w…
View article: Untangling Associations of Microbiomes of Pregnancy and Preterm Birth
Untangling Associations of Microbiomes of Pregnancy and Preterm Birth Open
View article: Placental transfer dynamics and durability of maternal COVID-19 vaccine-induced antibodies in infants
Placental transfer dynamics and durability of maternal COVID-19 vaccine-induced antibodies in infants Open
To profile maternal SARS-CoV-2 vaccine-induced specific antibodies and evaluate their transplacental transfer and persistence in infants at 2, 6, 9, and 12 months of age using systems serology. This study highlights the importance of timin…
View article: The role of neighborhood deprivation in the cervicovaginal microbiota
The role of neighborhood deprivation in the cervicovaginal microbiota Open
View article: 718 Identification of Black Birthing People at Highest Risk for Suicide
718 Identification of Black Birthing People at Highest Risk for Suicide Open
View article: 673 Mental health needs after preterm birth: A qualitative assessment of Black women’s experiences
673 Mental health needs after preterm birth: A qualitative assessment of Black women’s experiences Open
View article: Placental transfer dynamics and durability of maternal COVID-19 vaccine-induced antibodies in infants
Placental transfer dynamics and durability of maternal COVID-19 vaccine-induced antibodies in infants Open
SUMMARY Completion of a COVID-19 vaccination series during pregnancy effectively reduces COVID-19 hospitalization among infants less than 6 months of age. Elucidating the dynamics of transplacental transfer of maternal vaccine-induced anti…
View article: Vaginal microbes alter epithelial transcriptomic and epigenomic modifications providing insight into the molecular mechanisms for susceptibility to adverse reproductive outcomes
Vaginal microbes alter epithelial transcriptomic and epigenomic modifications providing insight into the molecular mechanisms for susceptibility to adverse reproductive outcomes Open
View article: Regulatory T cell adoptive transfer alters uterine immune populations, increasing a novel MHC-IIlow macrophage associated with healthy pregnancy
Regulatory T cell adoptive transfer alters uterine immune populations, increasing a novel MHC-IIlow macrophage associated with healthy pregnancy Open
Intrauterine fetal demise (IUFD) – fetal loss after 20 weeks – affects 6 pregnancies per 1,000 live births in the United States, and the majority are of unknown etiology. Maternal systemic regulatory T cell (Treg) deficits have been implic…
View article: Cervicovaginal Microbial–Immune State and Group B Streptococcus Colonization in Pregnancy
Cervicovaginal Microbial–Immune State and Group B Streptococcus Colonization in Pregnancy Open
Objective Maternal colonization with Group B Streptococcus (GBS) is a significant risk factor for serious neonatal morbidity. There are limited data on how the cervicovaginal (CV) microbiota and host immune factor β-defensin-2 might influe…
View article: Intrauterine colonization with <i>Gardnerella vaginalis</i> and <i>Mobiluncus mulieris</i> induces maternal inflammation but not preterm birth in a mouse model
Intrauterine colonization with <i>Gardnerella vaginalis</i> and <i>Mobiluncus mulieris</i> induces maternal inflammation but not preterm birth in a mouse model Open
Problem Preterm birth (PTB) remains a leading cause of childhood mortality. Recent studies demonstrate that the risk of spontaneous PTB (sPTB) is increased in individuals with Lactobacillus ‐deficient vaginal microbial communities. One pro…
View article: Impact of exposure to air pollution on cervicovaginal microbial communities
Impact of exposure to air pollution on cervicovaginal microbial communities Open
View article: The impact of postpartum social support on postpartum mental health outcomes during the COVID-19 pandemic
The impact of postpartum social support on postpartum mental health outcomes during the COVID-19 pandemic Open