Michal Pechar
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View article: Nanomedicines for Delivery of Cytarabine: Effect of Carrier Structure and Spacer on the Anti-Lymphoma Efficacy
Nanomedicines for Delivery of Cytarabine: Effect of Carrier Structure and Spacer on the Anti-Lymphoma Efficacy Open
High-dose therapy with cytarabine (araC) is a standard treatment for aggressive non-Hodgkin lymphomas, but its efficacy is limited by rapid enzymatic degradation. To overcome this, araC was conjugated to N-(2-hydroxypropyl)methacrylamide (…
View article: Polymer Nanomedicines with pH-Triggered Pirarubicin Release: Revealing the Role of Carrier Hydrophilicity and Release Kinetics in Anticancer Performance
Polymer Nanomedicines with pH-Triggered Pirarubicin Release: Revealing the Role of Carrier Hydrophilicity and Release Kinetics in Anticancer Performance Open
The therapeutic efficacy of antitumor nanomedicines is influenced by numerous factors, with the most critical being the selection of an appropriate biomaterial and the use of suitable stimulus-responsive linkers. The chosen biomaterial mus…
View article: Desmoplastic tumor priming using clinical-stage corticosteroid liposomes
Desmoplastic tumor priming using clinical-stage corticosteroid liposomes Open
View article: Cationic‐Hydrophilic Di‐Block Copolymers: Surface‐Shielded Vectors for Gene Delivery
Cationic‐Hydrophilic Di‐Block Copolymers: Surface‐Shielded Vectors for Gene Delivery Open
To tackle the main challenges in gene therapy, synthetic polycationic vectors are developed for nucleic acid (NA) delivery. In this work, vectors based on di‐block copolymers consisting of a methacrylate‐type cationic block and an electron…
View article: Dual Thermo- and pH-Responsive Polymer Nanoparticle Assemblies for Potential Stimuli-Controlled Drug Delivery
Dual Thermo- and pH-Responsive Polymer Nanoparticle Assemblies for Potential Stimuli-Controlled Drug Delivery Open
The development of stimuli-responsive drug delivery systems enables targeted delivery and environment-controlled drug release, thereby minimizing off-target effects and systemic toxicity. We prepared and studied tailor-made dual-responsive…
View article: Synthesis and Structure Optimization of Star Copolymers as Tunable Macromolecular Carriers for Minimal Immunogen Vaccine Delivery
Synthesis and Structure Optimization of Star Copolymers as Tunable Macromolecular Carriers for Minimal Immunogen Vaccine Delivery Open
Minimal immunogen vaccines are being developed to focus antibody responses against otherwise challenging targets, including human immunodeficiency virus (HIV), but multimerization of the minimal peptide immunogen on a carrier platform is r…
View article: Histopathological biomarkers for predicting the tumour accumulation of nanomedicines
Histopathological biomarkers for predicting the tumour accumulation of nanomedicines Open
View article: RGD-coated polymeric microbubbles promote ultrasound-mediated drug delivery in an inflamed endothelium-pericyte co-culture model of the blood-brain barrier
RGD-coated polymeric microbubbles promote ultrasound-mediated drug delivery in an inflamed endothelium-pericyte co-culture model of the blood-brain barrier Open
View article: Highly hydrophilic methacrylamide-based copolymers as precursors for polymeric nanomedicines containing anthracyclines
Highly hydrophilic methacrylamide-based copolymers as precursors for polymeric nanomedicines containing anthracyclines Open
The crucial limitation of most low molecular weight cytostatic drugs, including anthracyclines, is their nonspecific biodistribution causing severe adverse effects during cancer treatment. Recently, nanomedicines such as polymer-based syst…
View article: Dual Thermo- and Ph-Responsive Polymer Nanoparticle Assemblies for Potential Stimuli-Controlled Drug Delivery
Dual Thermo- and Ph-Responsive Polymer Nanoparticle Assemblies for Potential Stimuli-Controlled Drug Delivery Open
View article: Tumor-specific targeting of polymer drug delivery systems with recombinant proteins bound via tris(nitrilotriacetic acid)
Tumor-specific targeting of polymer drug delivery systems with recombinant proteins bound via tris(nitrilotriacetic acid) Open
Antibody-mediated targeting is an efficient strategy to enhance the specificity and selectivity of polymer nanomedicines towards the target site, typically a tumor. However, direct covalent coupling of an antibody with a polymer usually re…
View article: Tumor-Specific Targeting of Polymer Drug Delivery Systems with Recombinant Proteins Bound via Tris(Nitrilotriacetic Acid)
Tumor-Specific Targeting of Polymer Drug Delivery Systems with Recombinant Proteins Bound via Tris(Nitrilotriacetic Acid) Open
Antibody-mediated targeting is an efficient strategy to enhance the specificity and selectivity of polymer nanomedicines towards the target site, typically a tumor. However, direct covalent coupling of an antibody with a polymer usually re…
View article: Stimuli‐Responsive Polymer Nanoprobes Intended for Fluorescence‐Guided Surgery of Malignant Head‐and‐Neck Tumors and Metastases
Stimuli‐Responsive Polymer Nanoprobes Intended for Fluorescence‐Guided Surgery of Malignant Head‐and‐Neck Tumors and Metastases Open
Nano‐sized carriers are widely studied as suitable candidates for the advanced delivery of various bioactive molecules such as drugs and diagnostics. Herein, the development of long‐circulating stimuli‐responsive polymer nanoprobes tailore…
View article: Effect of Cellular and Microenvironmental Multidrug Resistance on Tumor-Targeted Drug Delivery in Triple-Negative Breast cancer
Effect of Cellular and Microenvironmental Multidrug Resistance on Tumor-Targeted Drug Delivery in Triple-Negative Breast cancer Open
View article: Polymer-Antimicrobial Peptide Constructs with Tailored Drug-Release Behavior
Polymer-Antimicrobial Peptide Constructs with Tailored Drug-Release Behavior Open
Microbial resistance is one of the main problems of modern medicine. Recently, antimicrobial peptides have been recognized as a novel approach to overcome the microbial resistance issue, nevertheless, their low stability, toxicity, and pot…
View article: Radiosensitizing molybdenum iodide nanoclusters conjugated with a biocompatible <i>N</i>-(2-hydroxypropyl)methacrylamide copolymer: a step towards radiodynamic therapy
Radiosensitizing molybdenum iodide nanoclusters conjugated with a biocompatible <i>N</i>-(2-hydroxypropyl)methacrylamide copolymer: a step towards radiodynamic therapy Open
A radiosensitizing nanosystem made of octahedral molybdenum clusters conjugated with a biocompatible HPMA polymer shows promise towards radiodynamic therapy.
View article: Octahedral Molybdenum Cluster-Based Nanomaterials for Potential Photodynamic Therapy
Octahedral Molybdenum Cluster-Based Nanomaterials for Potential Photodynamic Therapy Open
Photo/radiosensitizers, such as octahedral molybdenum clusters (Mo6), have been intensively studied for photodynamic applications to treat various diseases. However, their delivery to the desired target can be hampered by its limited solub…
View article: Retraction Note: Selective Priming of Tumor Blood Vessels by Radiation Therapy Enhances Nanodrug Delivery
Retraction Note: Selective Priming of Tumor Blood Vessels by Radiation Therapy Enhances Nanodrug Delivery Open
View article: Tumor Marker B7-H6 Bound to the Coiled Coil Peptide-Polymer Conjugate Enables Targeted Therapy by Activating Human Natural Killer Cells
Tumor Marker B7-H6 Bound to the Coiled Coil Peptide-Polymer Conjugate Enables Targeted Therapy by Activating Human Natural Killer Cells Open
Targeted cancer immunotherapy is a promising tool for restoring immune surveillance and eradicating cancer cells. Hydrophilic polymers modified with coiled coil peptide tags can be used as universal carriers designed for cell-specific deli…
View article: Polymer‐Based Drug‐Free Therapeutics for Anticancer, Anti‐Inflammatory, and Antibacterial Treatment
Polymer‐Based Drug‐Free Therapeutics for Anticancer, Anti‐Inflammatory, and Antibacterial Treatment Open
Inside Front Cover: The precise biorecognition of natural binding motifs by multiple vectors on the polymer construct is a crucial part of the designing of polymer-based drug-free macromolecular therapeutics, a novel class of therapeutics …
View article: Cytarabine nanotherapeutics with increased stability and enhanced lymphoma uptake for tailored highly effective therapy of mantle cell lymphoma
Cytarabine nanotherapeutics with increased stability and enhanced lymphoma uptake for tailored highly effective therapy of mantle cell lymphoma Open
Mantle cell lymphoma (MCL) is a rare subtype of B-cell non-Hodgkin lymphoma (B-NHL) with chronically relapsing clinical course. Implementation of cytarabine (araC) into induction and salvage regimen became standard of care for majority of …
View article: Author Correction: Selective Priming of Tumor Blood Vessels by Radiation Therapy Enhances Nanodrug Delivery
Author Correction: Selective Priming of Tumor Blood Vessels by Radiation Therapy Enhances Nanodrug Delivery Open
View article: Polymer Cancerostatics Containing Cell-Penetrating Peptides: Internalization Efficacy Depends on Peptide Type and Spacer Length
Polymer Cancerostatics Containing Cell-Penetrating Peptides: Internalization Efficacy Depends on Peptide Type and Spacer Length Open
Cell-penetrating peptides (CPPs) are commonly used substances enhancing the cellular uptake of various cargoes that do not easily cross the cellular membrane. CPPs can be either covalently bound directly to the cargo or they can be attache…
View article: Targeted Polymer-Based Probes for Fluorescence Guided Visualization and Potential Surgery of EGFR-Positive Head-and-Neck Tumors
Targeted Polymer-Based Probes for Fluorescence Guided Visualization and Potential Surgery of EGFR-Positive Head-and-Neck Tumors Open
This report describes the design, synthesis and evaluation of tumor-targeted polymer probes to visualize epidermal growth factor receptor (EGFR)-positive malignant tumors for successful resection via fluorescence guided endoscopic surgery.…
View article: Cytarabine Nanotherapeutics with Increased Stability and Enhanced Lymphoma Uptake for Tailored Highly Effective Therapy of Mantle Cell Lymphoma
Cytarabine Nanotherapeutics with Increased Stability and Enhanced Lymphoma Uptake for Tailored Highly Effective Therapy of Mantle Cell Lymphoma Open
View article: Multimodal and multiscale optical imaging of nanomedicine delivery across the blood-brain barrier upon sonopermeation
Multimodal and multiscale optical imaging of nanomedicine delivery across the blood-brain barrier upon sonopermeation Open
Rationale: The blood-brain barrier (BBB) is a major obstacle for drug delivery to the brain. Sonopermeation, which relies on the combination of ultrasound and microbubbles, has emerged as a powerful tool to permeate the BBB, enablin…
View article: RETRACTED ARTICLE: Selective Priming of Tumor Blood Vessels by Radiation Therapy Enhances Nanodrug Delivery
RETRACTED ARTICLE: Selective Priming of Tumor Blood Vessels by Radiation Therapy Enhances Nanodrug Delivery Open
View article: Cell-Penetrating Peptides: a Useful Tool for the Delivery of Various Cargoes Into Cells
Cell-Penetrating Peptides: a Useful Tool for the Delivery of Various Cargoes Into Cells Open
Cell-penetrating compounds are substances that enhance the cellular uptake of various molecular cargoes that do not easily cross the cellular membrane. The majority of cell-penetrating compounds described in the literature are cell-penetra…
View article: Histidine-rich glycoprotein-induced vascular normalization improves EPR-mediated drug targeting to and into tumors
Histidine-rich glycoprotein-induced vascular normalization improves EPR-mediated drug targeting to and into tumors Open
View article: Targeted Drug Delivery by Radiation-Induced Tumor Vascular Modulation
Targeted Drug Delivery by Radiation-Induced Tumor Vascular Modulation Open
Effective drug delivery is severely restricted by the presence of complex pathophysiological barriers in solid tumors. In human pancreatic adenocarcinoma, mature and hypopermeable tumor blood vessels limit the permeation and penetration of…