Michal Polonsky
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View article: PATH-51. Identification of molecular markers predicting malignant transformation in low grade gliomas
PATH-51. Identification of molecular markers predicting malignant transformation in low grade gliomas Open
Low-grade gliomas generally have an indolent course and good prognosis after maximal safe resection; however, progression to high-grade gliomas via malignant transformation is a poorly understood process. In order to further elucidate the …
View article: Spatial transcriptomics defines injury specific microenvironments and cellular interactions in kidney regeneration and disease
Spatial transcriptomics defines injury specific microenvironments and cellular interactions in kidney regeneration and disease Open
View article: Spatial transcriptomics defines injury-specific microenvironments in the adult mouse kidney and novel cellular interactions in regeneration and disease
Spatial transcriptomics defines injury-specific microenvironments in the adult mouse kidney and novel cellular interactions in regeneration and disease Open
Kidney injury disrupts the intricate renal architecture and triggers limited regeneration, and injury-invoked inflammation and fibrosis. Deciphering molecular pathways and cellular interactions driving these processes is challenging due to…
View article: #6014 SINGLE-CELL SPATIAL TRANSCRIPTOMICS OF THE KIDNEY IN HEALTH AND DISEASE DEFINES INJURY-SPECIFIC DOMAINS AND IDENTIFIES NOVEL CELL-CELL INTERACTIONS
#6014 SINGLE-CELL SPATIAL TRANSCRIPTOMICS OF THE KIDNEY IN HEALTH AND DISEASE DEFINES INJURY-SPECIFIC DOMAINS AND IDENTIFIES NOVEL CELL-CELL INTERACTIONS Open
Background and Aims Single-cell sequencing has revealed an unexpected diversity of cell types throughout the body. However, the loss of spatial context in many single-cell sequencing techniques hampers our understanding of cell-cell intera…
View article: Dynamic changes in tRNA modifications and abundance during T cell activation
Dynamic changes in tRNA modifications and abundance during T cell activation Open
The tRNA pool determines the efficiency, throughput, and accuracy of translation. Previous studies have identified dynamic changes in the tRNA (transfer RNA) supply and mRNA (messenger RNA) demand during cancerous proliferation. Yet dynami…
View article: Dynamic changes in tRNA modifications and abundance during T-cell activation
Dynamic changes in tRNA modifications and abundance during T-cell activation Open
The tRNA pool determines the efficiency, throughput, and accuracy of translation. Previous studies have identified dynamic changes in the tRNA supply and mRNA demand during cancerous proliferation. Yet, dynamic changes may occur also durin…
View article: Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation
Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation Open
Monocytes are circulating mononuclear phagocytes, poised to extravasate to sites of inflammation and differentiate into monocyte-derived macrophages and dendritic cells. Tumor necrosis factor (TNF) and its receptors are up-regulated during…