Michal Schäfer
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View article: Donation after circulatory death with thoracoabdominal normothermic regional perfusion recovery has similar outcomes with donation after brain death for lung transplantation
Donation after circulatory death with thoracoabdominal normothermic regional perfusion recovery has similar outcomes with donation after brain death for lung transplantation Open
Lung transplantation outcomes were not significantly different between lung grafts recovered by DCD TA-NRP and DBD. This early data suggests TA-NRP may not adversely impact DCD lung allografts during procurement.
View article: Symptomatic Left Main Coronary Artery Aneurysm With Intraluminal Thrombus
Symptomatic Left Main Coronary Artery Aneurysm With Intraluminal Thrombus Open
View article: Root and arch replacements in acute type A aortic dissection suggest lower risk of open distal reintervention
Root and arch replacements in acute type A aortic dissection suggest lower risk of open distal reintervention Open
Objective: This study aimed to evaluate how different approaches for root and arch management during the first surgery for acute type A aortic dissection impact long-term freedom from reintervention, particularly distal reintervention. Met…
View article: Assessment of diastolic function in overweight individuals with and without uncomplicated type 2 diabetes using comprehensive CMR and 4D flow MRI
Assessment of diastolic function in overweight individuals with and without uncomplicated type 2 diabetes using comprehensive CMR and 4D flow MRI Open
View article: High Flow, High-Pressure Retrograde Cerebral Perfusion at 28°C is Safe and Effective for Hemiarch Replacement of the Ascending Aorta
High Flow, High-Pressure Retrograde Cerebral Perfusion at 28°C is Safe and Effective for Hemiarch Replacement of the Ascending Aorta Open
Traditional retrograde cerebral perfusion (RCP) parameters may be suboptimal for washout of debris during hemiarch replacement of the ascending aorta, so we have designed a protocol of increased RCP pressure and flow at moderate hypothermi…
View article: Aortic shape with high-acute isthmic angle post frozen elephant trunk reconstruction is associated with worse postoperative outcomes: Multisite, principal component analysis, retrospective study
Aortic shape with high-acute isthmic angle post frozen elephant trunk reconstruction is associated with worse postoperative outcomes: Multisite, principal component analysis, retrospective study Open
Objective: Aortic shape and geometry after surgical reconstruction have been shown to be important determinants of flow hemodynamics, aortic remodeling, and clinical outcomes. In this study, we investigated aortic shapes post-frozen elepha…
View article: Application of Principal Component Analysis to Heterogenous Fontan Registry Data Identifies Independent Contributing Factors to Decline
Application of Principal Component Analysis to Heterogenous Fontan Registry Data Identifies Independent Contributing Factors to Decline Open
Single ventricle heart disease is a severe and life-threatening illness, and improvements in clinical outcomes of those with Fontan circulation have not yet yielded acceptable survival over the past two decades. Patients are at risk of dev…
View article: Advanced Imaging Technologies for Assessing Tetralogy of Fallot: Insights Into Flow Dynamics
Advanced Imaging Technologies for Assessing Tetralogy of Fallot: Insights Into Flow Dynamics Open
Tetralogy of Fallot is the most common cyanotic congenital heart defect requiring surgical repair. Although surgical interventions have significantly reduced mortality, postrepair complications, such as pulmonary valve regurgitation and st…
View article: Lung recovery utilizing thoracoabdominal normothermic regional perfusion during donation after circulatory death: The Colorado experience
Lung recovery utilizing thoracoabdominal normothermic regional perfusion during donation after circulatory death: The Colorado experience Open
Despite concern regarding quality of DCD lung allografts recovered using the TA-NRP technique, we report initial success using this procurement method. Implementation of strategies to mitigate pulmonary edema can result in acceptable outco…
View article: 4D‐Flow MRI intracardiac flow analysis considering different subtypes of pulmonary hypertension
4D‐Flow MRI intracardiac flow analysis considering different subtypes of pulmonary hypertension Open
Intracardiac flow hemodynamic patterns have been considered to be an early sign of diastolic dysfunction. In this study we investigated right ventricular (RV) diastolic dysfunction between patients with pulmonary arterial hypertension (PAH…
View article: Hemi-Fontan and bidirectional Glenn operations result in flow-mediated viscous energy loss at the time of stage II palliation
Hemi-Fontan and bidirectional Glenn operations result in flow-mediated viscous energy loss at the time of stage II palliation Open
View article: Obesity dominates early effects on cardiac structure and arterial stiffness in people with type 2 diabetes
Obesity dominates early effects on cardiac structure and arterial stiffness in people with type 2 diabetes Open
Objective: Type 2 diabetes (T2D) and obesity are global epidemics leading to excess cardiovascular disease (CVD). This study investigates standard and novel cardiac MRI parameters to detect subclinical cardiac and central vascular dysfunct…
View article: Myocardial strain-curve deformation patterns after Fontan operation
Myocardial strain-curve deformation patterns after Fontan operation Open
Myocardial deformation analysis by cardiac MRI (CMR) yielding global circumferential and longitudinal strain (GCS and GLS) is an increasingly utilized method to accurately quantify systolic function and predict clinical events in patients …
View article: Aortic shape variation after frozen elephant trunk procedure predicts aortic events: Principal component analysis study
Aortic shape variation after frozen elephant trunk procedure predicts aortic events: Principal component analysis study Open
The second principal component, describing angulation at the region of the aortic isthmus, was associated with adverse aortic events. Observed shape variation should be evaluated in the context of aortic biomechanical properties and flow h…
View article: Ventricular global function index is associated with clinical outcomes in pediatric pulmonary hypertension
Ventricular global function index is associated with clinical outcomes in pediatric pulmonary hypertension Open
View article: Bromocriptine Improves Central Aortic Stiffness in Adolescents With Type 1 Diabetes: Arterial Health Results From the BCQR-T1D Study
Bromocriptine Improves Central Aortic Stiffness in Adolescents With Type 1 Diabetes: Arterial Health Results From the BCQR-T1D Study Open
Background: The presence of vascular dysfunction is a well-recognized feature in youth with type 1 diabetes (T1D), accentuating their lifetime risk of cardiovascular events. Therapeutic strategies to mitigate vascular dysfunction are a hig…
View article: Estimation of glomerular filtration rate in a pediatric population using non-contrast kidney phase contrast magnetic resonance imaging
Estimation of glomerular filtration rate in a pediatric population using non-contrast kidney phase contrast magnetic resonance imaging Open
View article: Coupled waveform patterns in the arterial and venous fontan circulation are related to parameters of pulmonary, lymphatic and cardiac function
Coupled waveform patterns in the arterial and venous fontan circulation are related to parameters of pulmonary, lymphatic and cardiac function Open
The lack of a sub-pulmonary ventricle in patients with a Fontan circulation contributes to circulatory decline, largely related to increased central venous pressure. Our group has determined that single-site waveform analysis correlates wi…
View article: Bromocriptine <scp>quick‐release</scp> as adjunct therapy in youth and adults with type 1 diabetes: A randomized, <scp>placebo‐controlled</scp> crossover study
Bromocriptine <span>quick‐release</span> as adjunct therapy in youth and adults with type 1 diabetes: A randomized, <span>placebo‐controlled</span> crossover study Open
Aim To evaluate the potential for glycaemic, renal and vascular benefits of bromocriptine quick release (BCQR) in adolescents and adults with type 1 diabetes. Materials and Methods Forty adolescents and 40 adults with type 1 diabetes aged …
View article: Acute appendicitis following the COVID-19 vaccine
Acute appendicitis following the COVID-19 vaccine Open
We report the case of a previously healthy 69-year-old female who developed appendicitis after receiving the third dose of the Pfizer-BioNTech Coronavirus Disease 2019 (COVID-19) vaccine; no other triggers were identified. We speculate tha…
View article: Reply from authors: The unbearable weight of shape and flow quality
Reply from authors: The unbearable weight of shape and flow quality Open
View article: Repolarization Dispersion Is Associated With Diastolic Electromechanical Discoordination in Children With Pulmonary Arterial Hypertension
Repolarization Dispersion Is Associated With Diastolic Electromechanical Discoordination in Children With Pulmonary Arterial Hypertension Open
Background Electromechanical dyssynchrony is a well described comorbidity in pulmonary arterial hypertension (PAH). ECG‐derived measurements reflective of diastolic dysfunction and electromechanical imaging markers are yet to be investigat…
View article: Coupled Waveform Patterns in the Arterial and Venous Fontan Circulation are Related to Parameters of Pulmonary, Lymphatic and Cardiac Function
Coupled Waveform Patterns in the Arterial and Venous Fontan Circulation are Related to Parameters of Pulmonary, Lymphatic and Cardiac Function Open
View article: Segmentation of the Aorta and Pulmonary Arteries Based on <scp>4D</scp> Flow <scp>MRI</scp> in the Pediatric Setting Using Fully Automated Multi‐Site, Multi‐Vendor, and Multi‐Label Dense U‐Net
Segmentation of the Aorta and Pulmonary Arteries Based on <span>4D</span> Flow <span>MRI</span> in the Pediatric Setting Using Fully Automated Multi‐Site, Multi‐Vendor, and Multi‐Label Dense U‐Net Open
Background Automated segmentation using convolutional neural networks (CNNs) have been developed using four‐dimensional (4D) flow magnetic resonance imaging (MRI). To broaden usability for congenital heart disease (CHD), training with mult…
View article: Metalloproteinases and their inhibitors are associated with pulmonary arterial stiffness and ventricular function in pediatric pulmonary hypertension
Metalloproteinases and their inhibitors are associated with pulmonary arterial stiffness and ventricular function in pediatric pulmonary hypertension Open
Metalloproteinases have been associated with clinical outcomes in pulmonary hypertension and with specific pathological features of ventricular dysfunction and pulmonary arterial remodeling. In this study, we demonstrated that plasma circu…
View article: Importance of neonatal strain imaging: what are we measuring?
Importance of neonatal strain imaging: what are we measuring? Open
View article: Short‐Term Effects of Inhaled Nitric Oxide on Right Ventricular Flow Hemodynamics by 4‐Dimensional–Flow Magnetic Resonance Imaging in Children With Pulmonary Arterial Hypertension
Short‐Term Effects of Inhaled Nitric Oxide on Right Ventricular Flow Hemodynamics by 4‐Dimensional–Flow Magnetic Resonance Imaging in Children With Pulmonary Arterial Hypertension Open
Background Pulmonary arterial hypertension (PAH) manifests with progressive right ventricular (RV) dysfunction, which eventually impairs the left ventricular function. We hypothesized that 4‐dimensional–flow magnetic resonance imaging can …
View article: Serum copeptin and NT-proBNP is associated with central aortic stiffness and flow hemodynamics in adolescents with type 1 diabetes: A pilot study
Serum copeptin and NT-proBNP is associated with central aortic stiffness and flow hemodynamics in adolescents with type 1 diabetes: A pilot study Open
View article: Impact of Obesity on Measures of Cardiovascular and Kidney Health in Youth With Type 1 Diabetes as Compared With Youth With Type 2 Diabetes
Impact of Obesity on Measures of Cardiovascular and Kidney Health in Youth With Type 1 Diabetes as Compared With Youth With Type 2 Diabetes Open
OBJECTIVE Insulin resistance and obesity are independently associated with type 1 diabetes (T1D) and are known risk factors for cardiovascular and kidney diseases, the leading causes of death in T1D. We evaluated the effect of BMI on cardi…
View article: Reply to Commentary: Can't flow down: More 4-dimensional flow magnetic resonance imaging studies are needed in congenital heart disease
Reply to Commentary: Can't flow down: More 4-dimensional flow magnetic resonance imaging studies are needed in congenital heart disease Open