Michel Doumith
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View article: Frequencies and mechanisms of mutational resistance to ceftibuten/avibactam in Enterobacterales
Frequencies and mechanisms of mutational resistance to ceftibuten/avibactam in Enterobacterales Open
Background Antibiotic resistance complicates treatment of urinary infections, particularly when these ascend above the bladder, with few oral options remaining. New oral β-lactamase inhibitor combinations present a potential answer, with c…
View article: Ceftriaxone-resistant <i>Neisseria gonorrhoeae</i> detected in England, 2015–24: an observational analysis
Ceftriaxone-resistant <i>Neisseria gonorrhoeae</i> detected in England, 2015–24: an observational analysis Open
Objectives Since June 2022, there has been a rise in the number of ceftriaxone-resistant Neisseria gonorrhoeae cases detected in England (n = 15), of which a third were XDR. We describe the demographic and clinical details of the recent ca…
View article: Ceftriaxone-resistant<i>Neisseria gonorrhoeae</i>detected in England, 2015 to 2024; an observational study
Ceftriaxone-resistant<i>Neisseria gonorrhoeae</i>detected in England, 2015 to 2024; an observational study Open
Background Since June 2022, there has been a rise in the number of ceftriaxone resistant Neisseria gonorrhoeae cases detected in England (n = 15), of which one third were extensively-drug resistant (XDR). We describe the demographic and cl…
View article: Genomic epidemiology and longitudinal sampling of ward wastewater environments and patients reveals complexity of the transmission dynamics of <i>bla</i> KPC-carbapenemase-producing Enterobacterales in a hospital setting
Genomic epidemiology and longitudinal sampling of ward wastewater environments and patients reveals complexity of the transmission dynamics of <i>bla</i> KPC-carbapenemase-producing Enterobacterales in a hospital setting Open
Background Healthcare-associated wastewater and asymptomatic patient reservoirs colonized by carbapenemase-producing Enterobacterales (CPE) contribute to nosocomial CPE dissemination, but the characteristics and dynamics of this remain unc…
View article: Molecular Basis of Antimicrobial Resistance in Group B Streptococcus Clinical Isolates from Saudi Arabia
Molecular Basis of Antimicrobial Resistance in Group B Streptococcus Clinical Isolates from Saudi Arabia Open
Published data on the molecular mechanisms underlying antimicrobial resistance in Group B Streptococcus (GBS) isolates from Saudi Arabia are lacking. Here, we aimed to determine the genetic basis of resistance to relevant antibiotics in a …
View article: Genomic insights into the diversity, virulence, and antimicrobial resistance of group B Streptococcus clinical isolates from Saudi Arabia
Genomic insights into the diversity, virulence, and antimicrobial resistance of group B Streptococcus clinical isolates from Saudi Arabia Open
Introduction Detailed assessment of the population structure of group B Streptococcus (GBS) among adults is still lacking in Saudi Arabia. Here we characterized a representative collection of isolates from colonized and infected adults. Me…
View article: Molecular typing and antimicrobial resistance of group B Streptococcus clinical isolates in Saudi Arabia
Molecular typing and antimicrobial resistance of group B Streptococcus clinical isolates in Saudi Arabia Open
GBS isolates belonged predominantly to serotypes III and V, but there were no clear associations between serotypes and patient groups. The studied isolates exhibited high levels of resistance to erythromycin and clindamycin that need furth…
View article: Molecular characterization and differential effects of levofloxacin and ciprofloxacin on the potential for developing quinolone resistance among clinical Pseudomonas aeruginosa isolates
Molecular characterization and differential effects of levofloxacin and ciprofloxacin on the potential for developing quinolone resistance among clinical Pseudomonas aeruginosa isolates Open
Background Fluoroquinolones are some of the most used antimicrobial agents for the treatment of Pseudomonas aeruginosa . This study aimed at exploring the differential activity of ciprofloxacin and levofloxacin on the selection of resistan…
View article: Epididymo-Orchitis Caused by POM-1 Metallo-β-Lactamase-Producing Pseudomonas otitidis in an Immunocompetent Patient: Case Report and Molecular Characterization
Epididymo-Orchitis Caused by POM-1 Metallo-β-Lactamase-Producing Pseudomonas otitidis in an Immunocompetent Patient: Case Report and Molecular Characterization Open
Pseudomonas otitidis is a rare and unique species among the Pseudomonas genus that has not been previously reported as a cause of male genitourinary tract infection. In this report, we describe a case of a 20-year-old immunocompetent male …
View article: In vitro activity of cefiderocol against clinically important carbapenem non-susceptible Gram-negative bacteria from Saudi Arabia
In vitro activity of cefiderocol against clinically important carbapenem non-susceptible Gram-negative bacteria from Saudi Arabia Open
Cefiderocol had excellent activity against multi-drug resistant non-fermenting Gram-negative pathogens. Reasons behind the high cefiderocol MICs in certain Enterobacterales isolates need further investigation.
View article: Diversity of carbapenemase-producing Enterobacterales in England as revealed by whole-genome sequencing of isolates referred to a national reference laboratory over a 30-month period
Diversity of carbapenemase-producing Enterobacterales in England as revealed by whole-genome sequencing of isolates referred to a national reference laboratory over a 30-month period Open
Introduction. Increasing numbers of carbapenemase-producing Enterobacterales (CPE), which can be challenging to treat, have been referred to the national reference laboratory in England since the early 2000s. Gap Statement/Aim. Previous st…
View article: Genomic Characterization of Carbapenem-Non-susceptible Pseudomonas aeruginosa Clinical Isolates From Saudi Arabia Revealed a Global Dissemination of GES-5-Producing ST235 and VIM-2-Producing ST233 Sub-Lineages
Genomic Characterization of Carbapenem-Non-susceptible Pseudomonas aeruginosa Clinical Isolates From Saudi Arabia Revealed a Global Dissemination of GES-5-Producing ST235 and VIM-2-Producing ST233 Sub-Lineages Open
Carbapenem-resistant P. aeruginosa has become a major clinical problem due to limited treatment options. However, studies assessing the trends in the molecular epidemiology and mechanisms of antibiotic resistance in this pathogen are lacki…
View article: Acquired resistome and plasmid sequencing of <i>mcr</i>-<i>1</i> carrying MDR Enterobacteriaceae from poultry and their relationship to STs associated with humans
Acquired resistome and plasmid sequencing of <i>mcr</i>-<i>1</i> carrying MDR Enterobacteriaceae from poultry and their relationship to STs associated with humans Open
Objectives To investigate the acquired resistome in 18 colistin-resistant Escherichia coli isolated from different poultry farms in Lebanon, analyse Inc plasmids associated with mcr and assess potential transmission to humans. Methods A to…
View article: Emergence of new SARS-CoV-2 variant under investigation in Saudi Arabia
Emergence of new SARS-CoV-2 variant under investigation in Saudi Arabia Open
Genomic surveillance helps public health tracking the path of a pandemic, understand its transmission route, and how quickly the virus is spreading and adapting through mutation and recombination. In late 2020, the Infectious Diseases Rese…
View article: Successful treatment of infective endocarditis due to pandrug-resistant Klebsiella pneumoniae with ceftazidime-avibactam and aztreonam
Successful treatment of infective endocarditis due to pandrug-resistant Klebsiella pneumoniae with ceftazidime-avibactam and aztreonam Open
Pandrug-resistant (PDR) K. pneumoniae refractory to conventional treatment has been reported worldwide, causing a huge burden on the healthcare system, patient safety and the economy. K. pneumoniae is a prominent opportunistic pathogen cau…
View article: Genomic Epidemiology of Complex, Multispecies, Plasmid-Borne <i>bla</i> <sub>KPC</sub> Carbapenemase in <i>Enterobacterales</i> in the United Kingdom from 2009 to 2014
Genomic Epidemiology of Complex, Multispecies, Plasmid-Borne <i>bla</i> <sub>KPC</sub> Carbapenemase in <i>Enterobacterales</i> in the United Kingdom from 2009 to 2014 Open
Carbapenem resistance in Enterobacterales is a public health threat. Klebsiella pneumoniae carbapenemase (encoded by alleles of the bla KPC family) is one of the most common transmissible carbapenem resistance mechanisms worldwide. The dis…
View article: The characterization of mobile colistin resistance (mcr) genes among 33 000 Salmonella enterica genomes from routine public health surveillance in England
The characterization of mobile colistin resistance (mcr) genes among 33 000 Salmonella enterica genomes from routine public health surveillance in England Open
To establish the prevalence of mobile colistin resistance ( mcr ) genes amongst Salmonella enterica isolates obtained through public health surveillance in England (April 2014 to September 2017), 33 205 S . enterica genome sequences obtain…
View article: Comparison of phenotypic and WGS-derived antimicrobial resistance profiles of Campylobacter jejuni and Campylobacter coli isolated from cases of diarrhoeal disease in England and Wales, 2015–16
Comparison of phenotypic and WGS-derived antimicrobial resistance profiles of Campylobacter jejuni and Campylobacter coli isolated from cases of diarrhoeal disease in England and Wales, 2015–16 Open
Objectives To compare and evaluate phenotypic and genotypic methods for the detection of antimicrobial resistance (AMR) in Campylobacter jejuni and Campylobacter coli in England and Wales. Methods WGS data from 528 isolates of Campylobacte…
View article: Emergence of diversity in carbapenemase-producing Escherichia coli ST131, England, January 2014 to June 2016
Emergence of diversity in carbapenemase-producing Escherichia coli ST131, England, January 2014 to June 2016 Open
Background Escherichia coli ST131, a global, high-risk clone, comprises fluoroquinolone resistance (FQ-R) mutations and CTX-M extended-spectrum beta-lactamases associated with the fimH 30-encoding clades, C1 and C2. Further carbapenem resi…
View article: S. Enteritidis and S. Typhimurium Harboring SPI-1 and SPI-2 Are the Predominant Serotypes Associated With Human Salmonellosis in Saudi Arabia
S. Enteritidis and S. Typhimurium Harboring SPI-1 and SPI-2 Are the Predominant Serotypes Associated With Human Salmonellosis in Saudi Arabia Open
Non-typhoidal Salmonella (NTS) strains are Gram negative bacterial pathogens that are associated with foodborne illness worldwide. During the process of infection, Salmonella uses two molecular injectisomes known as Type 3 Secretion System…
View article: Complete Genome Sequence of a Colistin-Resistant Uropathogenic Escherichia coli Sequence Type 131 <i>fimH</i> 22 Strain Harboring <i>mcr-1</i> on an IncHI2 Plasmid, Isolated in Riyadh, Saudi Arabia
Complete Genome Sequence of a Colistin-Resistant Uropathogenic Escherichia coli Sequence Type 131 <i>fimH</i> 22 Strain Harboring <i>mcr-1</i> on an IncHI2 Plasmid, Isolated in Riyadh, Saudi Arabia Open
We report the complete genome sequence of a colistin-resistant strain of uropathogenic Escherichia coli , isolated in January 2013 at King Abdulaziz Medical City (KAMC), Riyadh, Saudi Arabia. The isolate (named SA186) was sequence type 131…