Michel Neunlist
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View article: Elevated levels of colonic interleukin-1beta and interleukin-8 in isolated REM sleep behavior disorder without associated changes in permeability
Elevated levels of colonic interleukin-1beta and interleukin-8 in isolated REM sleep behavior disorder without associated changes in permeability Open
Some recent studies suggest that gastrointestinal inflammation could play a role in the development of Parkinson’s disease (PD) by increasing intestinal permeability and triggering early neuropathological changes in the gut. Therefore, we …
View article: Enteric glia promotes the survival of CD4 and CD8 T cells in plexitis: a new player in Crohn’s disease recurrence?
Enteric glia promotes the survival of CD4 and CD8 T cells in plexitis: a new player in Crohn’s disease recurrence? Open
Both CD4 and CD8 T cells adhere to enteric glial cells in patients with Crohn’s disease, contributing to the development of plexitis associated with postoperative recurrence. The adhesion of CD4 and CD8 T cells to enteric glial cells is de…
View article: SOX10-Mediated Regulation of Enteric Glial Phenotype in vitro and its Relevance for Neuroinflammatory Disorders
SOX10-Mediated Regulation of Enteric Glial Phenotype in vitro and its Relevance for Neuroinflammatory Disorders Open
View article: Gut, vaginal, and urinary microbiota as potential biomarkers of sensitization in women with chronic pelvic pain
Gut, vaginal, and urinary microbiota as potential biomarkers of sensitization in women with chronic pelvic pain Open
View article: Confocal laser endomicroscopy as predictive biomarker of clinical and endoscopic efficacy of vedolizumab in ulcerative colitis: The DETECT study
Confocal laser endomicroscopy as predictive biomarker of clinical and endoscopic efficacy of vedolizumab in ulcerative colitis: The DETECT study Open
Aims In patients with ulcerative colitis (UC), no biomarker is available to help the physician to choose the most suitable biotherapy. The primary objective of this pilot study was to assess the feasibility of identification of α4β7- and T…
View article: The regulation of enteric neuron connectivity by semaphorin 5A is affected by the autism-associated S956G missense mutation
The regulation of enteric neuron connectivity by semaphorin 5A is affected by the autism-associated S956G missense mutation Open
View article: Does a rectal biopsy with intestinal barrier permeability assessment could be a biomarker of sacral neuromodulation success in fecal incontinent patients?
Does a rectal biopsy with intestinal barrier permeability assessment could be a biomarker of sacral neuromodulation success in fecal incontinent patients? Open
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View article: Characterization of mitochondria-associated ER membranes in the enteric nervous system under physiological and pathological conditions
Characterization of mitochondria-associated ER membranes in the enteric nervous system under physiological and pathological conditions Open
Our work shows for the first time the presence of contacts between endoplasmic reticulum and mitochondria in the enteric neurons and that the dynamic of these contacts is affected in these cells from an age-related neurodegeneration mouse …
View article: Transient gestational hypothyroxinemia accelerates and enhances ulcerative colitis-like disorder in the male offspring
Transient gestational hypothyroxinemia accelerates and enhances ulcerative colitis-like disorder in the male offspring Open
Introduction Gestational hypothyroxinemia (HTX) is a condition that occurs frequently at the beginning of pregnancy, and it correlates with cognitive impairment, autism, and attentional deficit in the offspring. Evidence in animal models s…
View article: P027 Involvement of PD-L1 in myenteric plexitis associated with postoperative recurrence of Crohn's disease
P027 Involvement of PD-L1 in myenteric plexitis associated with postoperative recurrence of Crohn's disease Open
Background Despite a growing therapeutic armamentarium, post-operative recurrence (POR) in Crohn’s disease (CD) remains frequent. The presence of myenteric plexitis at the proximal margin of ileocolonic resection has been recognized as a r…
View article: Enteric Glial Cells at the Crossroads Between Intestinal Inflammation and Amyloids Diseases
Enteric Glial Cells at the Crossroads Between Intestinal Inflammation and Amyloids Diseases Open
View article: Role of ICAM-1 in the Adhesion of T Cells to Enteric Glia: Perspectives in the Formation of Plexitis in Crohn’s Disease
Role of ICAM-1 in the Adhesion of T Cells to Enteric Glia: Perspectives in the Formation of Plexitis in Crohn’s Disease Open
Our present work argues for a role of glia-T-cell interaction in the development of myenteric plexitis through the adhesion molecules ICAM-1/LFA-1 and suggests that deciphering the functional consequences of glia-T-cell interaction is impo…
View article: Region-specific remodeling of the enteric nervous system and enteroendocrine cells in the colon of spinal cord injury patients
Region-specific remodeling of the enteric nervous system and enteroendocrine cells in the colon of spinal cord injury patients Open
View article: Wake and non-rapid eye movement sleep dysfunction is associated with colonic neuropathology in Parkinson’s disease
Wake and non-rapid eye movement sleep dysfunction is associated with colonic neuropathology in Parkinson’s disease Open
Study Objectives The body-first Parkinson’s disease (PD) hypothesis suggests initial gut Lewy body pathology that propagates to the pons before reaching the substantia nigra, and subsequently progresses to the diencephalic and cortical lev…
View article: Are LRRK2 mysteries lurking in the gut?
Are LRRK2 mysteries lurking in the gut? Open
Gut-brain axis and inflammation are two hot topics in Parkinson’s disease (PD). In this setting, the leucine-rich repeat kinase 2 ( LRRK2) gene, which encodes the eponym protein, has attracted much attention. LRRK2 is not only the gene mos…
View article: Tau expression and phosphorylation in enteroendocrine cells
Tau expression and phosphorylation in enteroendocrine cells Open
Background and objective There is mounting evidence to suggest that the gut-brain axis is involved in the development of Parkinson’s disease (PD). In this regard, the enteroendocrine cells (EEC), which faces the gut lumen and are connected…
View article: Sacral neuromodulation for refractory ulcerative colitis: safety and efficacy in a prospective observational series of eight patients
Sacral neuromodulation for refractory ulcerative colitis: safety and efficacy in a prospective observational series of eight patients Open
View article: Data from Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis
Data from Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis Open
Gut dysbiosis has been associated with intestinal and extraintestinal malignancies, but whether and how carcinogenesis drives compositional shifts of the microbiome to its own benefit remains an open conundrum. Here, we show that malignant…
View article: Data from Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis
Data from Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis Open
Gut dysbiosis has been associated with intestinal and extraintestinal malignancies, but whether and how carcinogenesis drives compositional shifts of the microbiome to its own benefit remains an open conundrum. Here, we show that malignant…
View article: Supplementary Figure from Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis
Supplementary Figure from Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis Open
Supplementary Figure from Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis
View article: Supplementary Figure from Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis
Supplementary Figure from Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis Open
Supplementary Figure from Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis
View article: Supplementary Figure from Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis
Supplementary Figure from Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis Open
Supplementary Figure from Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis
View article: Supplementary Figure from Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis
Supplementary Figure from Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis Open
Supplementary Figure from Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis
View article: Data from Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity
Data from Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity Open
Ceramide-induced endothelial cell apoptosis boosts intestinal stem cell radiosensitivity. However, the molecular connection between these two cellular compartments has not been clearly elucidated. Here we report that ceramide and its relat…
View article: Supplementary Figure 2 from Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity
Supplementary Figure 2 from Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity Open
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View article: Supplementary Figure 1 from Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity
Supplementary Figure 1 from Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity Open
SupFigure 1
View article: Supplementary Figure 6 from Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity
Supplementary Figure 6 from Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity Open
SupFigure6
View article: Supplementary Figure 7 from Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity
Supplementary Figure 7 from Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity Open
SupFigure7
View article: Supplementary Figure 2 from Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity
Supplementary Figure 2 from Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity Open
SupFigure2
View article: Supplementary Figure 3 from Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity
Supplementary Figure 3 from Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity Open
SupFigure3