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View article: Exploring traditional Japanese herbal ointments for wound healing: A wide diversity of practices, metabolites, and effects
Exploring traditional Japanese herbal ointments for wound healing: A wide diversity of practices, metabolites, and effects Open
This study highlights the diversity and complexity of traditional Kampo ointments in terms of chemical composition and, to a lesser extent, biological activity. Preparation temperature and ingredient origin markedly shaped the metabolite p…
View article: Type I Interferon Signaling Defines a Novel Disease Signature in Xeroderma Pigmentosum C Human Keratinocytes
Type I Interferon Signaling Defines a Novel Disease Signature in Xeroderma Pigmentosum C Human Keratinocytes Open
Xeroderma Pigmentosum C (XPC) is a DNA damage recognition protein central to the global genome nucleotide excision repair (GG-NER) pathway, where it acts as a primary sensor of UV-induced DNA lesions. Loss-of-function mutations in the XPC …
View article: QUANTITATIVE PROTEOMICS OF PLASMA EXTRACELLULAR VESICLES REVEALS A TTR-PLASMINOGEN NETWORK IN ATTR CARDIAC AMYLOIDOSIS
QUANTITATIVE PROTEOMICS OF PLASMA EXTRACELLULAR VESICLES REVEALS A TTR-PLASMINOGEN NETWORK IN ATTR CARDIAC AMYLOIDOSIS Open
Background Despite recent progress, the prognosis of patients with transthyretin (TTR) cardiac amyloidosis remains poor; this is primarily due to late diagnosis, when irreversible damage has already occurred. Today’s diagnostic work-up sti…
View article: Pharmacy Education and Clinical Pharmacy Training in France
Pharmacy Education and Clinical Pharmacy Training in France Open
Clinical pharmacy education varies widely between European countries, and several major changes have taken place in France. This review aims to describe the current state of pharmacy education in France, focusing on clinical pharmacy. Rese…
View article: Matrix stiffness regulates the protein profile of extracellular vesicles of pancreatic cancer cell lines
Matrix stiffness regulates the protein profile of extracellular vesicles of pancreatic cancer cell lines Open
The fibrotic stroma characterizing pancreatic ductal adenocarcinoma (PDAC) derives from a progressive tissue rigidification, which induces epithelial mesenchymal transition and metastatic dissemination. The aim of this study was to investi…
View article: Value of a secretomic approach for distinguishing patients with COVID‐19 viral pneumonia among patients with respiratory distress admitted to intensive care unit
Value of a secretomic approach for distinguishing patients with COVID‐19 viral pneumonia among patients with respiratory distress admitted to intensive care unit Open
In intensive care units, COVID‐19 viral pneumonia patients (VPP) present symptoms similar to those of other patients with Nonviral infection (NV‐ICU). To better manage VPP, it is therefore interesting to better understand the molecular pat…
View article: Complete title: Value of a secretomic approach for distinguishing patients with COVID-19 viral pneumonia among patients with respiratory distress admitted to intensive care unit Shortened title: Secretomic to distinguish COVID-19 patients
Complete title: Value of a secretomic approach for distinguishing patients with COVID-19 viral pneumonia among patients with respiratory distress admitted to intensive care unit Shortened title: Secretomic to distinguish COVID-19 patients Open
Introduction : In intensive care units, COVID-19 viral pneumonia patients (VPP) present symptoms similar to those of other patients with non-viral infection (NV-ICU). To better manage VPP, it is therefore interesting to better understand t…
View article: Effect of Ultraviolet Radiation and Benzo[a]pyrene Co-Exposure on Skin Biology: Autophagy as a Potential Target
Effect of Ultraviolet Radiation and Benzo[a]pyrene Co-Exposure on Skin Biology: Autophagy as a Potential Target Open
The skin is the outermost protective barrier of the human body. Its role is to protect against different physical, chemical, biological and environmental stressors. The vast majority of studies have focused on investigating the effects of …
View article: Kampo herbal ointments for skin wound healing
Kampo herbal ointments for skin wound healing Open
The management of skin wound healing problems is a public health issue in which traditional herbal medicines could play a determining role. Kampo medicine, with three traditionally used ointments, provides interesting solutions for these d…
View article: Untargeted metabolomics approach to discriminate mistletoe commercial products
Untargeted metabolomics approach to discriminate mistletoe commercial products Open
Mistletoe ( Viscum album L.) is used in German-speaking European countries in the field of integrative oncology linking conventional and complementary medicine therapies to improve quality of life. Various companies sell extracts, fermente…
View article: Analysis of Astroglial Secretomic Profile in the Mecp2-Deficient Male Mouse Model of Rett Syndrome
Analysis of Astroglial Secretomic Profile in the Mecp2-Deficient Male Mouse Model of Rett Syndrome Open
Mutations in the X-linked MECP2 gene are responsible for Rett syndrome (RTT), a severe neurological disorder. MECP2 is a transcriptional modulator that finely regulates the expression of many genes, specifically in the central nervous syst…
View article: Quantitative Proteomic Approach Reveals Altered Metabolic Pathways in Response to the Inhibition of Lysine Deacetylases in A549 Cells under Normoxia and Hypoxia
Quantitative Proteomic Approach Reveals Altered Metabolic Pathways in Response to the Inhibition of Lysine Deacetylases in A549 Cells under Normoxia and Hypoxia Open
Growing evidence is showing that acetylation plays an essential role in cancer, but studies on the impact of KDAC inhibition (KDACi) on the metabolic profile are still in their infancy. Here, we analyzed, by using an iTRAQ-based quantitati…
View article: The Secretome Deregulations in a Rat Model of Endotoxemic Shock
The Secretome Deregulations in a Rat Model of Endotoxemic Shock Open
Introduction . Septic shock is a systemic inflammatory response syndrome associated with organ failures. Earlier clinical diagnosis would be of benefit to a decrease in the mortality rate. However, there is currently a lack of predictive b…
View article: Xeroderma Pigmentosum C: A Valuable Tool to Decipher the Signaling Pathways in Skin Cancers
Xeroderma Pigmentosum C: A Valuable Tool to Decipher the Signaling Pathways in Skin Cancers Open
Xeroderma pigmentosum (XP) is a rare autosomal genodermatosis that manifests clinically with pronounced sensitivity to ultraviolet (UV) radiation and the high probability of the occurrence of different skin cancer types in XP patients. XP …
View article: Identification, Characterization and Synthesis of Walterospermin, a Sperm Motility Activator from the Egyptian Black Snake Walterinnesia aegyptia Venom
Identification, Characterization and Synthesis of Walterospermin, a Sperm Motility Activator from the Egyptian Black Snake Walterinnesia aegyptia Venom Open
Animal venoms are small natural mixtures highly enriched in bioactive components. They are known to target at least two important pharmacological classes of cell surface receptors: ion channels and G protein coupled receptors. Since sperm …
View article: Impairment of Base Excision Repair in Dermal Fibroblasts Isolated From Nevoid Basal Cell Carcinoma Patients
Impairment of Base Excision Repair in Dermal Fibroblasts Isolated From Nevoid Basal Cell Carcinoma Patients Open
The nevoid basal cell carcinoma syndrome (NBCCS), also called Gorlin syndrome is an autosomal dominant disorder whose incidence is estimated at about 1 per 55,600-256,000 individuals. It is characterized by several developmental abnormalit…
View article: Effects of Iron Oxide Nanoparticles (γ-Fe2O3) on Liver, Lung and Brain Proteomes following Sub-Acute Intranasal Exposure: A New Toxicological Assessment in Rat Model Using iTRAQ-Based Quantitative Proteomics
Effects of Iron Oxide Nanoparticles (γ-Fe2O3) on Liver, Lung and Brain Proteomes following Sub-Acute Intranasal Exposure: A New Toxicological Assessment in Rat Model Using iTRAQ-Based Quantitative Proteomics Open
Iron Oxide Nanoparticles (IONPs) present unique properties making them one of the most used NPs in the biomedical field. Nevertheless, for many years, growing production and use of IONPs are associated with risks that can affect human and …
View article: ISOLATION AND IN SILICO CHARACTERIZATION OF A LEISHMANICIDAL DISINTEGRIN FROM CERASTES CERASTES VENOM
ISOLATION AND IN SILICO CHARACTERIZATION OF A LEISHMANICIDAL DISINTEGRIN FROM CERASTES CERASTES VENOM Open
International audience
View article: In Vitro Dermal Safety Assessment of Silver Nanowires after Acute Exposure: Tissue vs. Cell Models
In Vitro Dermal Safety Assessment of Silver Nanowires after Acute Exposure: Tissue vs. Cell Models Open
Silver nanowires (AgNW) are attractive materials that are anticipated to be incorporated into numerous consumer products such as textiles, touchscreen display, and medical devices that could be in direct contact with skin. There are very f…
View article: Actiflagelin, a new sperm activator isolated from Walterinnesia aegyptia venom using phenotypic screening
Actiflagelin, a new sperm activator isolated from Walterinnesia aegyptia venom using phenotypic screening Open
Background Sperm contains a wealth of cell surface receptors and ion channels that are required for most of its basic functions such as motility and acrosome reaction. Conversely, animal venoms are enriched in bioactive compounds that prim…
View article: Proteomic Identification of Allergenic Proteins of Morus alba L. Pollen
Proteomic Identification of Allergenic Proteins of Morus alba L. Pollen Open
This study provides the first detailed information for the potential allergens of Morus alba pollen of Istanbul. Methionine synthase with an apparent molecular weight of 80 to 85 kDa has been recognized as one of the allergens in Morus alb…
View article: Low‐molecular‐weight color pI markers to monitor on‐line the peptide focusing process in OFFGEL fractionation
Low‐molecular‐weight color pI markers to monitor on‐line the peptide focusing process in OFFGEL fractionation Open
High‐throughput mass spectrometry‐based proteomic analysis requires peptide fractionation to simplify complex biological samples and increase proteome coverage. OFFGEL fractionation technology became a common method to separate peptides or…
View article: Tubulin Beta‐3 Chain as a New Candidate Protein Biomarker of Human Skin Aging: A Preliminary Study
Tubulin Beta‐3 Chain as a New Candidate Protein Biomarker of Human Skin Aging: A Preliminary Study Open
Skin aging is a complex process, and a lot of efforts have been made to identify new and specific targets that could help to diagnose, prevent, and treat skin aging. Several studies concerning skin aging have analyzed the changes in gene e…