Michel B. Tolédano
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View article: Cytokine, Chemokine, and Neurofilament Light Chain Signatures in <scp>LGI1</scp> Autoimmune Encephalitis
Cytokine, Chemokine, and Neurofilament Light Chain Signatures in <span>LGI1</span> Autoimmune Encephalitis Open
Objectives To investigate the value of cytokine, chemokine, and neurofilament light chain (NfL) concentrations in predicting relapse risk, chronic epilepsy, and functional impairment in LGI1 autoimmune encephalitis (AE). Methods Cytokines/…
View article: <scp>CSF</scp> cytokine, chemokine and injury biomarker profile of glial fibrillary acidic protein (<scp>GFAP</scp>) autoimmunity
<span>CSF</span> cytokine, chemokine and injury biomarker profile of glial fibrillary acidic protein (<span>GFAP</span>) autoimmunity Open
Defining the CSF cytokine/chemokine and injury biomarker signature of glial fibrillary acidic protein (GFAP) autoimmunity can inform immunopathogenesis. CSF GFAP‐IgG‐positive samples ( N = 98) were tested for 17 cytokines/chemokines, neuro…
View article: Neurohospitalist Core Competencies
Neurohospitalist Core Competencies Open
The Neurohospitalist Core Competencies comprise a set of competency-based learning objectives that encapsulate the knowledge, skills, and attitudes of neurohospitalitists who specialize in the care of hospitalized patients with neurologic …
View article: Mitochondrial Reactive Oxygen Species and Lytic Programmed Cell Death in Acute Inflammation
Mitochondrial Reactive Oxygen Species and Lytic Programmed Cell Death in Acute Inflammation Open
Significance: Redox signaling through mitochondrial reactive oxygen species (mtROS) has a key role in several mechanisms of regulated cell death (RCD), necroptosis, ferroptosis, pyroptosis, and apoptosis, thereby decisively contributing to…
View article: Critical Role of the Sulfiredoxin-Peroxiredoxin IV Axis in Urethane-Induced Non-Small Cell Lung Cancer
Critical Role of the Sulfiredoxin-Peroxiredoxin IV Axis in Urethane-Induced Non-Small Cell Lung Cancer Open
Non-small cell lung cancer (NSCLC), the most common type of lung cancer, etiologically associates with tobacco smoking which mechanistically contributes to oxidative stress to facilitate the occurrence of mutations, oncogenic transformatio…
View article: Autoimmune Encephalitis Misdiagnosis in Adults; A Multicenter Observational Study of Outpatient Subspecialty Clinics
Autoimmune Encephalitis Misdiagnosis in Adults; A Multicenter Observational Study of Outpatient Subspecialty Clinics Open
Objective To determine the diseases misdiagnosed as AE and potential reasons for misdiagnosis. Background Misdiagnosis of autoimmune encephalitis (AE) may harm patients. Design/Methods Patients with AE misdiagnosis were identified (1/1/201…
View article: Progressive Multifocal Leukoencephalopathy Associated With Sarcoidosis: A Multi-Center Case Series
Progressive Multifocal Leukoencephalopathy Associated With Sarcoidosis: A Multi-Center Case Series Open
Objective We aim to describe the clinical, laboratory, and radiographic features that characterize patients with progressive multifocal leukoencephalopathy (PML) in the context of sarcoidosis (S-PML). Background Sarcoidosis has been associ…
View article: Iron Insertion at the Assembly Site of the ISCU Scaffold Protein Is a Conserved Process Initiating Fe–S Cluster Biosynthesis
Iron Insertion at the Assembly Site of the ISCU Scaffold Protein Is a Conserved Process Initiating Fe–S Cluster Biosynthesis Open
Iron-sulfur (Fe-S) clusters are prosthetic groups of proteins biosynthesized on scaffold proteins by highly conserved multi-protein machineries. Biosynthesis of Fe-S clusters into the ISCU scaffold protein is initiated by ferrous iron inse…
View article: p53 drives necroptosis via downregulation of sulfiredoxin and peroxiredoxin 3
p53 drives necroptosis via downregulation of sulfiredoxin and peroxiredoxin 3 Open
Mitochondrial dysfunction is a key contributor to necroptosis. We have investigated the contribution of p53, sulfiredoxin, and mitochondrial peroxiredoxin 3 to necroptosis in acute pancreatitis. Late during the course of pancreatitis, p53 …
View article: Decision letter: Genetically controlled mtDNA deletions prevent ROS damage by arresting oxidative phosphorylation
Decision letter: Genetically controlled mtDNA deletions prevent ROS damage by arresting oxidative phosphorylation Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Deletion of mitochondr…
View article: Peroxiredoxin promotes longevity and H2O2-resistance in yeast through redox-modulation of protein kinase A
Peroxiredoxin promotes longevity and H2O2-resistance in yeast through redox-modulation of protein kinase A Open
Peroxiredoxins are H 2 O 2 scavenging enzymes that also carry out H 2 O 2 signaling and chaperone functions. In yeast, the major cytosolic peroxiredoxin, Tsa1 is required for both promoting resistance to H 2 O 2 and extending lifespan upon…
View article: Author response: Peroxiredoxin promotes longevity and H2O2-resistance in yeast through redox-modulation of protein kinase A
Author response: Peroxiredoxin promotes longevity and H2O2-resistance in yeast through redox-modulation of protein kinase A Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Peroxiredoxins are H2O2 scavenging enzymes…
View article: <scp>The importance of naturally attenuated SARS‐CoV</scp> ‐2 <scp>in the fight against COVID</scp> ‐19
<span>The importance of naturally attenuated SARS‐CoV</span> ‐2 <span>in the fight against COVID</span> ‐19 Open
The current SARS‐CoV‐2 pandemic is wreaking havoc throughout the world and has rapidly become a global health emergency. A central question concerning COVID‐19 is why some individuals become sick and others not. Many have pointed already a…
View article: Dynamics of a Key Conformational Transition in the Mechanism of Peroxiredoxin Sulfinylation
Dynamics of a Key Conformational Transition in the Mechanism of Peroxiredoxin Sulfinylation Open
Peroxiredoxins from the Prx1 subfamily (Prx) are moonlighting peroxidases that operate in peroxide signaling and are regulated by sulfinylation. Prxs offer a major model of protein-thiol oxidative modification. They react with H2O2 to form…
View article: A Redox-Sensitive Thiol in Wis1 Modulates the Fission Yeast Mitogen-Activated Protein Kinase Response to H<sub>2</sub>O<sub>2</sub> and Is the Target of a Small Molecule
A Redox-Sensitive Thiol in Wis1 Modulates the Fission Yeast Mitogen-Activated Protein Kinase Response to H<sub>2</sub>O<sub>2</sub> and Is the Target of a Small Molecule Open
Oxidation of a highly conserved cysteine (Cys) residue located in the kinase activation loop of mitogen-activated protein kinase kinases (MAPKK) inactivates mammalian MKK6. This residue is conserved in the fission yeast Schizosaccharomyces…
View article: Peroxiredoxin promotes longevity and H<sub>2</sub>O<sub>2</sub>-resistance in yeast through redox-modulation of protein kinase A
Peroxiredoxin promotes longevity and H<sub>2</sub>O<sub>2</sub>-resistance in yeast through redox-modulation of protein kinase A Open
Peroxiredoxins are H 2 O 2 scavenging enzymes that also carry H 2 O 2 signaling and chaperone functions. In yeast, the major cytosolic peroxiredoxin, Tsa1 is required for both promoting resistance to H 2 O 2 and extending lifespan upon cal…
View article: Nonlinear feedback drives homeostatic plasticity in H2O2 stress response
Nonlinear feedback drives homeostatic plasticity in H2O2 stress response Open
Homeostatic systems that rely on genetic regulatory networks are intrinsically limited by the transcriptional response time, which may restrict a cell’s ability to adapt to unanticipated environmental challenges. To bypass this limitation,…
View article: Author response: Nonlinear feedback drives homeostatic plasticity in H2O2 stress response
Author response: Nonlinear feedback drives homeostatic plasticity in H2O2 stress response Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Homeostatic systems that rely on genetic regula…
View article: In vivo parameters influencing 2-Cys Prx oligomerization: The role of enzyme sulfinylation
In vivo parameters influencing 2-Cys Prx oligomerization: The role of enzyme sulfinylation Open
2-Cys Prxs are H2O2-specific antioxidants that become inactivated by enzyme hyperoxidation at elevated H2O2 levels. Although hyperoxidation restricts the antioxidant physiological role of these enzymes, it also allows the enzyme to become …
View article: Adaptive aneuploidy protects against thiol peroxidase deficiency by increasing respiration via key mitochondrial proteins
Adaptive aneuploidy protects against thiol peroxidase deficiency by increasing respiration via key mitochondrial proteins Open
Significance Aneuploidy, a condition of abnormal chromosomal content, can support adaptive mechanisms in response to environmental cues but comes at the expense of decreased proliferation and dysfunction of cellular processes. Here we show…
View article: Mammalian frataxin directly enhances sulfur transfer of NFS1 persulfide to both ISCU and free thiols
Mammalian frataxin directly enhances sulfur transfer of NFS1 persulfide to both ISCU and free thiols Open
Friedreich's ataxia is a severe neurodegenerative disease caused by the decreased expression of frataxin, a mitochondrial protein that stimulates iron-sulfur (Fe-S) cluster biogenesis. In mammals, the primary steps of Fe-S cluster assembly…