Michel Vaillant
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View article: Quantifying anti-trypanosomal treatment effects in chronic indeterminate Chagas disease: a secondary analysis of individual patient data from two proof-of-concept trials
Quantifying anti-trypanosomal treatment effects in chronic indeterminate Chagas disease: a secondary analysis of individual patient data from two proof-of-concept trials Open
Wellcome Trust.
View article: New regimens of benznidazole for the treatment of chronic Chagas disease in adult participants in indeterminate form or with mild cardiac progression (NuestroBen study): protocol for a phase III randomised, multicentre non-inferiority clinical trial
New regimens of benznidazole for the treatment of chronic Chagas disease in adult participants in indeterminate form or with mild cardiac progression (NuestroBen study): protocol for a phase III randomised, multicentre non-inferiority clinical trial Open
Introduction Chagas disease (CD) is one of the most neglected diseases in the world. In Latin America, CD is endemic in 21 countries, with an estimated 70 million people at risk of infection. Current treatments are limited to two nitrohete…
View article: Reduction in Onchocerca volvulus infection prevalence and intensity in Logo Health Zone in Ituri, Democratic Republic of the Congo, in the absence of interventions: Results of screening for clinical trials of moxidectin vs. ivermectin in 2010 and 2021-2023
Reduction in Onchocerca volvulus infection prevalence and intensity in Logo Health Zone in Ituri, Democratic Republic of the Congo, in the absence of interventions: Results of screening for clinical trials of moxidectin vs. ivermectin in 2010 and 2021-2023 Open
Background: In Ituri province, 7576 and 1056 volunteers living in the Health Zone (ZdS) Logo and Nyarambe, respectively, were screened in 2021-2023 for two studies comparing efficacy and/or safety of moxidectin and ivermectin in individual…
View article: Correction: Creation of a pandemic memory by tracing COVID-19 infections and immunity in Luxembourg (CON-VINCE)
Correction: Creation of a pandemic memory by tracing COVID-19 infections and immunity in Luxembourg (CON-VINCE) Open
View article: Waning of anti-SARS-CoV-2 antibodies after the first wave of the COVID-19 pandemic in 2020: A 12-month-evaluation in three population-based European studies
Waning of anti-SARS-CoV-2 antibodies after the first wave of the COVID-19 pandemic in 2020: A 12-month-evaluation in three population-based European studies Open
Objectives We described waning in anti-SARS-CoV-2 IgG in adult general populations infected during the first wave of the COVID-19 pandemic in 2020 across three European countries. Methods Coordinated analyses were conducted separately in t…
View article: Space and Time Dynamics of Honeybee (Apis mellifera L.)-Melliferous Resource Interactions Within a Foraging Area: A Case Study in the Banja Luka Region (Bosnia & Herzegovina)
Space and Time Dynamics of Honeybee (Apis mellifera L.)-Melliferous Resource Interactions Within a Foraging Area: A Case Study in the Banja Luka Region (Bosnia & Herzegovina) Open
Interactions between honeybees and the environment are often difficult to achieve, particularly when the purpose is to optimize beekeeping production. The present study proposed to monitor the space-time variations of melliferous resources…
View article: Adaptive Design for Phase II/III Platform Trial of Lassa Fever Therapeutics
Adaptive Design for Phase II/III Platform Trial of Lassa Fever Therapeutics Open
The current recommendation for treating Lassa fever with ribavirin is supported only by weak evidence. Given the persistent effects in areas with endemic transmission and epidemic potential, there is an urgent need to reassess ribavirin an…
View article: Immunophenotyping of Patients With Rheumatoid Arthritis Reveals Difference in CD27<sup>+</sup>IgD<sup>+</sup> Unswitched Memory B Cell Profiles.
Immunophenotyping of Patients With Rheumatoid Arthritis Reveals Difference in CD27<sup>+</sup>IgD<sup>+</sup> Unswitched Memory B Cell Profiles. Open
Objectives: Over the past decades, the prevalence of noncommunicable diseases has surged significantly, including the systemic autoimmune disorder rheumatoid arthritis (RA). Despite extensive research and advancement of RA therapy, …
View article: Lessons learned from the COVID-19 pandemic: identifying hesitant groups and exploring reasons for vaccination hesitancy, from adolescence to late adulthood
Lessons learned from the COVID-19 pandemic: identifying hesitant groups and exploring reasons for vaccination hesitancy, from adolescence to late adulthood Open
Introduction The COVID-19 (COronaVIrus Disease-2019) pandemic highlighted the importance of assessing the rationales behind vaccine hesitancy for the containment of pandemics. In this nationwide study, representative of the Luxembourgish p…
View article: Evaluating artesunate monotherapy and dihydroartemisinin-piperaquine as potential antimalarial options for prevaccination radical cures during future malaria vaccine field efficacy trials
Evaluating artesunate monotherapy and dihydroartemisinin-piperaquine as potential antimalarial options for prevaccination radical cures during future malaria vaccine field efficacy trials Open
NCT04601714.
View article: Fear of hypoglycemia and sleep in children with type 1 diabetes and their parents
Fear of hypoglycemia and sleep in children with type 1 diabetes and their parents Open
Aims To compare impact of pump treatment and continuous glucose monitoring (CGM) with predictive low glucose suspend (SmartGuard) or user initiated CGM (iscCGM) on sleep and hypoglycemia fear in children with type 1 Diabetes and parents. M…
View article: Learning from post-COVID-19 condition for epidemic preparedness: a variable catalogue for future post-acute infection syndromes
Learning from post-COVID-19 condition for epidemic preparedness: a variable catalogue for future post-acute infection syndromes Open
View article: Facilitating comprehensive child health monitoring within REDCap - an open-source code for real-time Z-score assessments
Facilitating comprehensive child health monitoring within REDCap - an open-source code for real-time Z-score assessments Open
The integration with REDCap streamlines data collection and analysis, eliminating the need for separate software and data exports. Moreover, our solution uses the World Health Organization (WHO) growth standards and National Health and Nut…
View article: Cardiovascular history and risk of idiopathic Parkinson’s disease: a cross-sectional observational study
Cardiovascular history and risk of idiopathic Parkinson’s disease: a cross-sectional observational study Open
View article: Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms
Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms Open
Approximately one in seven COVID-19 patients presented at hospital admission without respiratory symptoms. These patients were older, had lower ICU admission rates, and had a lower risk of in-hospital mortality after adjusting for confound…
View article: Assessment of the impact of pregnancy and malaria infection on the variation of neutrophil levels in women from San, Mali
Assessment of the impact of pregnancy and malaria infection on the variation of neutrophil levels in women from San, Mali Open
Background: In patients with severe neutropenia, infections can rapidly become serious and life-threatening. It is essential to understand whether pregnancy induces changes in neutrophil levels thereby posing an increased threat to the hea…
View article: Neutropenia and its possible effect on the effectiveness of artemisinin-based combination therapy in pregnant women in Mali
Neutropenia and its possible effect on the effectiveness of artemisinin-based combination therapy in pregnant women in Mali Open
Background Reducing the burden of malaria in pregnant women remains a serious challenge for control programmes. A possible waning in immunity makes pregnant women more vulnerable to infectious diseases, including malaria. In this study, th…
View article: Facilitating Comprehensive Child Health Monitoring with Real-Time Z-Score assessments using REDCap
Facilitating Comprehensive Child Health Monitoring with Real-Time Z-Score assessments using REDCap Open
Background Monitoring of somatic development through the assessment of anthropometric variables such as weight, height and BMI is vital for evaluating the physical development and nutritional status of children. This approach aids in the e…
View article: Onchocerca volvulus microfilariae in the anterior chambers of the eye and ocular adverse events after a single dose of 8 mg moxidectin or 150 µg/kg ivermectin: results of a randomized double-blind Phase 3 trial in the Democratic Republic of the Congo, Ghana and Liberia
Onchocerca volvulus microfilariae in the anterior chambers of the eye and ocular adverse events after a single dose of 8 mg moxidectin or 150 µg/kg ivermectin: results of a randomized double-blind Phase 3 trial in the Democratic Republic of the Congo, Ghana and Liberia Open
Background After ivermectin became available, diethylcarbamazine (DEC) use was discontinued because of severe adverse reactions, including ocular reactions, in individuals with high Onchocerca volvulus microfilaridermia (microfilariae/mg s…
View article: Low diagnostic performance of thick blood smears of 50 µl in comparison with direct examination of 10 µl blood and the leukoconcentration technique of 5ml blood among loiasis-suspected patients with low microfilaremia in Gabon, Central Africa, using the STARD-BLCM guidelines
Low diagnostic performance of thick blood smears of 50 µl in comparison with direct examination of 10 µl blood and the leukoconcentration technique of 5ml blood among loiasis-suspected patients with low microfilaremia in Gabon, Central Africa, using the STARD-BLCM guidelines Open
Background The aim of this study was to determine performance indicators of thick blood smears of 50 µl (TBS-50), following the Standards for the Reporting of Diagnostic Accuracy Studies–Bayesian Latent Class Model (STARD-BLCM) guidelines.…
View article: Diagnostic tests for human Schistosoma mansoni and Schistosoma haematobium infection: a systematic review and meta-analysis
Diagnostic tests for human Schistosoma mansoni and Schistosoma haematobium infection: a systematic review and meta-analysis Open
View article: Creation of a pandemic memory by tracing COVID-19 infections and immunity in Luxembourg (CON-VINCE)
Creation of a pandemic memory by tracing COVID-19 infections and immunity in Luxembourg (CON-VINCE) Open
View article: Facilitating Comprehensive Child Health Monitoring with Real-Time Z-Score Assessments Using Redcap
Facilitating Comprehensive Child Health Monitoring with Real-Time Z-Score Assessments Using Redcap Open
View article: Luxembourg Parkinson’s study -comprehensive baseline analysis of Parkinson’s disease and atypical parkinsonism
Luxembourg Parkinson’s study -comprehensive baseline analysis of Parkinson’s disease and atypical parkinsonism Open
Background Deep phenotyping of Parkinson’s disease (PD) is essential to investigate this fastest-growing neurodegenerative disorder. Since 2015, over 800 individuals with PD and atypical parkinsonism along with more than 800 control subjec…
View article: Bubonic plague: can the size of buboes be accurately and consistently measured with a digital calliper?
Bubonic plague: can the size of buboes be accurately and consistently measured with a digital calliper? Open
Introduction Conducting clinical research on treatments for emerging infectious diseases is often complicated by methodological challenges, such as the identification of appropriate outcome measures to assess treatment response and the lac…
View article: The pipeline for drugs for control and elimination of neglected tropical diseases: 2. Oral anti-infective drugs and drug combinations for off-label use
The pipeline for drugs for control and elimination of neglected tropical diseases: 2. Oral anti-infective drugs and drug combinations for off-label use Open
View article: Bubonic plague: Can the size of buboes be accurately and consistently measured with a digital calliper?
Bubonic plague: Can the size of buboes be accurately and consistently measured with a digital calliper? Open
Introduction : Conducting clinical research on treatments for emerging infectious diseases is often complicated by methodological challenges, such as the identification of appropriate outcome measures to assess treatment response and the l…
View article: Novel, computational IgE‐clustering in a population‐based cross‐sectional study: Mapping the allergy burden
Novel, computational IgE‐clustering in a population‐based cross‐sectional study: Mapping the allergy burden Open
Background Even though the prevalence of allergies is increasing, population‐based data are still scarce. As a read‐out for chronic inflammatory information, new methods are needed to integrate individual biological measurements and lifest…
View article: Low Diagnostic Performance of Thick Blood Smears of 50 µL in Comparison with Blood Direct Examination of 10 µL and Leukoconcentration Techniques among Loiasis-Suspected Patients with Low Microfilaremia in Gabon, Central Africa, using the STARD-BCLM Guidelines
Low Diagnostic Performance of Thick Blood Smears of 50 µL in Comparison with Blood Direct Examination of 10 µL and Leukoconcentration Techniques among Loiasis-Suspected Patients with Low Microfilaremia in Gabon, Central Africa, using the STARD-BCLM Guidelines Open
Background The aim of the study was to determine performance indicators of the Thick Blood Smear of 50 µL (TBS-50), following Standards for the Reporting of Diagnostic Accuracy Studies-Bayesian Latent Class Analysis (STARD-BLCA) guidelines…
View article: Severe Anemia among Blood Donors in an Area Where Blood Donation Is Sought to Save the Lives of Children with Severe Malaria—Anemia in Blood Donors
Severe Anemia among Blood Donors in an Area Where Blood Donation Is Sought to Save the Lives of Children with Severe Malaria—Anemia in Blood Donors Open
Introduction: Severe anemia caused by severe malaria remains concentrated in children under 5 years old in Africa. In addition to blood-transfusion-related infections that pose a health concern, transfusion of severely anemic blood to a pa…