Michel Werner
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View article: Functional interplay between Mediator and RSC chromatin remodeling complex controls nucleosome-depleted region maintenance at promoters
Functional interplay between Mediator and RSC chromatin remodeling complex controls nucleosome-depleted region maintenance at promoters Open
Chromatin organization is crucial for transcriptional regulation in eukaryotes. Mediator is an essential and conserved co-activator thought to act in concert with chromatin regulators. However, it remains largely unknown how their function…
View article: Functional interplay between Mediator and RSC chromatin remodeling complex controls nucleosome-depleted region maintenance at promoters
Functional interplay between Mediator and RSC chromatin remodeling complex controls nucleosome-depleted region maintenance at promoters Open
Summary Chromatin organization is crucial for the transcriptional regulation in eukaryotes. Mediator is an essential and conserved coactivator thought to act in concert with chromatin regulators. However, it remains largely unknown how the…
View article: Toward understanding of the mechanisms of Mediator function<i>in vivo</i>: Focus on the preinitiation complex assembly
Toward understanding of the mechanisms of Mediator function<i>in vivo</i>: Focus on the preinitiation complex assembly Open
Mediator is a multisubunit complex conserved in eukaryotes that plays an essential coregulator role in RNA polymerase (Pol) II transcription. Despite intensive studies of the Mediator complex, the molecular mechanisms of its function in vi…
View article: Functional interplay between Mediator and TFIIB in preinitiation complex assembly in relation to promoter architecture
Functional interplay between Mediator and TFIIB in preinitiation complex assembly in relation to promoter architecture Open
Mediator is a large coregulator complex conserved from yeast to humans and involved in many human diseases, including cancers. Together with general transcription factors, it stimulates preinitiation complex (PIC) formation and activates R…
View article: Mediator independently orchestrates multiple steps of preinitiation complex assembly<i>in vivo</i>
Mediator independently orchestrates multiple steps of preinitiation complex assembly<i>in vivo</i> Open
Mediator is a large multiprotein complex conserved in all eukaryotes, which has a crucial coregulator function in transcription by RNA polymerase II (Pol II). However, the molecular mechanisms of its action in vivo remain to be understood.…
View article: List of drivers and barriers governing soil management by farmers, including cost aspects
List of drivers and barriers governing soil management by farmers, including cost aspects Open
This report consists of two components: (i) an overview of drivers and barriers for the adoption of so-called 'Best Management Practices' (BMPs) in soil management, as seen through the eyes of farmers (the extensive Chapter 2); and (ii) an…