Michela Riz
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View article: Tailoring the Padova Type 2 Diabetes Simulator for Treatment Guidance in Target Populations
Tailoring the Padova Type 2 Diabetes Simulator for Treatment Guidance in Target Populations Open
The proposed methodology makes the Padova T2DS usable for supporting treatment guidance in target T2D populations.
View article: Improved postprandial glucose metabolism in type 2 diabetes by the dual glucagon‐like peptide‐1/glucagon receptor agonist SAR425899 in comparison with liraglutide
Improved postprandial glucose metabolism in type 2 diabetes by the dual glucagon‐like peptide‐1/glucagon receptor agonist SAR425899 in comparison with liraglutide Open
Aim To gain further insights into the efficacy of SAR425899, a dual glucagon‐like peptide‐1/glucagon receptor agonist, by providing direct comparison with the glucagon‐like peptide‐1 receptor agonist, liraglutide, in terms of key outcomes …
View article: Team Players or Opponents: Coadministration of Selective Glucagon and GLP-1 Receptor Agonists in Obese Diabetic Monkeys
Team Players or Opponents: Coadministration of Selective Glucagon and GLP-1 Receptor Agonists in Obese Diabetic Monkeys Open
We assessed the therapeutic contribution of the individual components of glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR) agonists alone and in combination upon energy homeostasis and glycemic control in diet-induced …
View article: Ca2+ channel clustering with insulin-containing granules is disturbed in type 2 diabetes
Ca2+ channel clustering with insulin-containing granules is disturbed in type 2 diabetes Open
Loss of first-phase insulin secretion is an early sign of developing type 2 diabetes (T2D). Ca2+ entry through voltage-gated L-type Ca2+ channels triggers exocytosis of insulin-containing granules in pancreatic β cells and is required for …
View article: Mathematical Modeling of Interacting Glucose-Sensing Mechanisms and Electrical Activity Underlying Glucagon-Like Peptide 1 Secretion
Mathematical Modeling of Interacting Glucose-Sensing Mechanisms and Electrical Activity Underlying Glucagon-Like Peptide 1 Secretion Open
Intestinal L-cells sense glucose and other nutrients, and in response release glucagon-like peptide 1 (GLP-1), peptide YY and other hormones with anti-diabetic and weight-reducing effects. The stimulus-secretion pathway in L-cells is still…
View article: An index of parameter reproducibility accounting for estimation uncertainty: theory and case study on β-cell responsivity and insulin sensitivity
An index of parameter reproducibility accounting for estimation uncertainty: theory and case study on β-cell responsivity and insulin sensitivity Open
Parameter reproducibility is necessary to perform longitudinal studies where parameters are assessed to monitor disease progression or effect of therapy but are also useful in powering the study, i.e., to define how many subjects should be…
View article: Mathematical Modeling of Electrical Activity and Exocytosis in Intestinal L-cells and Pancreatic Beta-cells
Mathematical Modeling of Electrical Activity and Exocytosis in Intestinal L-cells and Pancreatic Beta-cells Open
In healthy subjects, glucose concentration is tightly kept in a limited range around its basal value thanks to complex regulatory mechanisms. Impairment of this regulatory system is the cause of several metabolic disorders, such as diabete…