Michelangela Barbieri
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View article: Adipose-tumor crosstalk in colorectal cancer: Identifying (Epi)genetic biomarkers for tumor progression and cachexia
Adipose-tumor crosstalk in colorectal cancer: Identifying (Epi)genetic biomarkers for tumor progression and cachexia Open
View article: Multi-omics strategies to decode the molecular landscape of cellular senescence
Multi-omics strategies to decode the molecular landscape of cellular senescence Open
View article: Impact of SGLT2-inhibitors on acute kidney injury in diabetic patients with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI)
Impact of SGLT2-inhibitors on acute kidney injury in diabetic patients with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI) Open
View article: Cognitive impairment in kidney transplanted patients
Cognitive impairment in kidney transplanted patients Open
Chronic kidney disease affects almost all of the organs. Recently, more attention has been paid to the kidney and the central nervous system connections. In patients on kidney replacement therapy, including kidney transplantation, there is…
View article: Care pathways for patients with cognitive impairment and chronic kidney disease
Care pathways for patients with cognitive impairment and chronic kidney disease Open
Various epidemiological datasets and pathophysiological hypotheses have highlighted a significant link between chronic kidney disease (CKD) and cognitive impairment (CI); each condition can potentially exacerbate the other. Here, we review…
View article: CONNECT: what has been done and what needs to be done
CONNECT: what has been done and what needs to be done Open
View article: Big databases and biobanks for studying the links between CKD, cognitive impairment, and dementia
Big databases and biobanks for studying the links between CKD, cognitive impairment, and dementia Open
Research on cognitive function in individuals with chronic kidney disease (CKD) is critical due to the significant public health challenge posed by both CKD and cognitive impairment. CKD affects approximately 10–15% of the adult population…
View article: Cognitive impairment in chronic kidney disease: role of brain imaging, functional imaging, electroencephalography, cerebrospinal fluid biomarkers and sensors
Cognitive impairment in chronic kidney disease: role of brain imaging, functional imaging, electroencephalography, cerebrospinal fluid biomarkers and sensors Open
Chronic kidney disease is associated with cognitive impairment although the underlying mechanisms are still not fully understood. Characterization and efficient monitoring of the cognitive impact of kidney disease and ensuing therapies are…
View article: Unlocking the power of empagliflozin: Rescuing inflammation in hyperglycaemia‐exposed human cardiomyocytes through comprehensive multi‐level analysis
Unlocking the power of empagliflozin: Rescuing inflammation in hyperglycaemia‐exposed human cardiomyocytes through comprehensive multi‐level analysis Open
Aims Hyperglycaemic conditions increase cardiac stress, a common phenomenon associated with inflammation, aging, and metabolic imbalance. Sodium–glucose cotransporter 2 inhibitors, a class of anti‐diabetic drugs, showed to improve cardiova…
View article: Correction: SGLT2-inhibitors in diabetic patients with severe aortic stenosis and cardiac damage undergoing transcatheter aortic valve implantation (TAVI)
Correction: SGLT2-inhibitors in diabetic patients with severe aortic stenosis and cardiac damage undergoing transcatheter aortic valve implantation (TAVI) Open
View article: SGLT2-inhibitors in diabetic patients with severe aortic stenosis and cardiac damage undergoing transcatheter aortic valve implantation (TAVI)
SGLT2-inhibitors in diabetic patients with severe aortic stenosis and cardiac damage undergoing transcatheter aortic valve implantation (TAVI) Open
In diabetic patients with severe AS, LVEF < 50%, and EVCD undergoing TAVI, the use of SGLT2i was associated with a more favorable cardiac remodeling and a reduced risk of MACE at 2-year follow-up.
View article: Cognitive impairment in CKD patients: a guidance document by the CONNECT network
Cognitive impairment in CKD patients: a guidance document by the CONNECT network Open
Cognitive impairment is a prevalent and debilitating complication in patients with chronic kidney disease (CKD). This position paper, developed by the Cognitive Decline in Nephro-Neurology: European Cooperative Target network, provides gui…
View article: Bridging the gap between GLP1-receptor agonists and cardiovascular outcomes: evidence for the role of tirzepatide
Bridging the gap between GLP1-receptor agonists and cardiovascular outcomes: evidence for the role of tirzepatide Open
View article: Is it time to revise the fighting strategy toward type 2 diabetes? Sex and pollution as new risk factors
Is it time to revise the fighting strategy toward type 2 diabetes? Sex and pollution as new risk factors Open
Diabetes mellitus, a metabolic condition affecting around 537 million individuals worldwide, poses significant challenges, particularly among the elderly population. The etiopathogenesis of type 2 diabetes (T2D) depends on a combination of…
View article: Atrial High-Rate Episodes in Elderly Patients: The Anticoagulation Therapy Dilemma
Atrial High-Rate Episodes in Elderly Patients: The Anticoagulation Therapy Dilemma Open
Atrial fibrillation (AF) has been associated with higher morbidity and mortality rates, especially in older patients. Subclinical atrial fibrillation (SCAF) is defined as the presence of atrial high-rate episodes (AHREs) > 190 bpm for 10 c…
View article: Drugs with a negative impact on cognitive functions (part 3): antibacterial agents in patients with chronic kidney disease
Drugs with a negative impact on cognitive functions (part 3): antibacterial agents in patients with chronic kidney disease Open
The relationship between chronic kidney disease (CKD) and cognitive function has received increased attention in recent years. Antibacterial agents (ABs) represent a critical component of therapy regimens in patients with CKD due to increa…
View article: SGK1 inhibition normalizes action potential duration in transgenic LQT2 rabbits but not in LQT1, suggesting a novel gene-specific therapeutic approach in long QT syndrome
SGK1 inhibition normalizes action potential duration in transgenic LQT2 rabbits but not in LQT1, suggesting a novel gene-specific therapeutic approach in long QT syndrome Open
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): SNSF (Swiss National Science Fundation) Background Increasing evidence suggests that secondary remodeling in Na+ and Ca2+ hom…
View article: Cognitive decline related to chronic kidney disease as an exclusion factor from kidney transplantation: results from an international survey
Cognitive decline related to chronic kidney disease as an exclusion factor from kidney transplantation: results from an international survey Open
Background and hypothesis There seems to be a lack of consensus on the necessity and the modality of psychological and specifically cognitive assessment of candidates for kidney transplantation. Both points are often delegated to individua…
View article: Evidence that tirzepatide protects against diabetes-related cardiac damages
Evidence that tirzepatide protects against diabetes-related cardiac damages Open
View article: Efficacy of erythropoietin as a neuroprotective agent in CKD-associated cognitive dysfunction: A literature systematic review
Efficacy of erythropoietin as a neuroprotective agent in CKD-associated cognitive dysfunction: A literature systematic review Open
Patients with chronic kidney disease (CKD) often experience mild cognitive impairment and other neurocognitive disorders. Studies have shown that erythropoietin (EPO) and its receptor have neuroprotective effects in cell and animal models …
View article: Circulating biomarkers of inflammaging and Alzheimer’s disease to track age-related trajectories of dementia: Can we develop a clinically relevant composite combination?
Circulating biomarkers of inflammaging and Alzheimer’s disease to track age-related trajectories of dementia: Can we develop a clinically relevant composite combination? Open
View article: Tirzepatide prevents neurodegeneration through multiple molecular pathways
Tirzepatide prevents neurodegeneration through multiple molecular pathways Open
Background Several evidence demonstrated that glucagon-like peptide 1 receptor agonists (GLP1-RAs) reduce the risk of dementia in type 2 diabetes patients by improving memory, learning, and overcoming cognitive impairment. In this study, w…
View article: Myocardial sodium–glucose cotransporter <scp>2</scp> expression and cardiac remodelling in patients with severe aortic stenosis: The <scp>BIO‐AS</scp> study
Myocardial sodium–glucose cotransporter <span>2</span> expression and cardiac remodelling in patients with severe aortic stenosis: The <span>BIO‐AS</span> study Open
Aim Cardiac remodelling plays a major role in the prognosis of patients with aortic stenosis (AS) and could impact the benefits of aortic valve replacement. Our study aimed to evaluate the expression of sodium–glucose cotransporter 2 (SGLT…
View article: On the wake of metformin: Do anti-diabetic SGLT2 inhibitors exert anti-aging effects?
On the wake of metformin: Do anti-diabetic SGLT2 inhibitors exert anti-aging effects? Open
View article: Multi-omics analysis reveals attenuation of cellular stress by empagliflozin in high glucose-treated human cardiomyocytes
Multi-omics analysis reveals attenuation of cellular stress by empagliflozin in high glucose-treated human cardiomyocytes Open
View article: Drugs with a negative impact on cognitive function (Part 1): chronic kidney disease as a risk factor
Drugs with a negative impact on cognitive function (Part 1): chronic kidney disease as a risk factor Open
People living with chronic kidney disease (CKD) frequently suffer from mild cognitive impairment and/or other neurocognitive disorders. This review in two parts will focus on adverse drug reactions resulting in cognitive impairment as a po…
View article: Drugs with a negative impact on cognitive functions (Part 2): drug classes to consider while prescribing in CKD patients
Drugs with a negative impact on cognitive functions (Part 2): drug classes to consider while prescribing in CKD patients Open
There is growing evidence that chronic kidney disease (CKD) is an independent risk factor for cognitive impairment, especially due to vascular damage, blood–brain barrier disruption and uremic toxins. Given the presence of multiple comorbi…
View article: Cognitive disorders in patients with chronic kidney disease: Approaches to prevention and treatment
Cognitive disorders in patients with chronic kidney disease: Approaches to prevention and treatment Open
Background Cognitive impairment is common in patients with chronic kidney disease (CKD), and early intervention may prevent the progression of this condition. Methods Here, we review interventions for the complications of CKD (anemia, seco…
View article: Dapagliflozin improves radial and longitudinal strain, increases pAMPK and reduces myocardial and renal NF-kB expression in preclinical models of doxorubicin cardiotoxicity through NLRP3 and Myd-88
Dapagliflozin improves radial and longitudinal strain, increases pAMPK and reduces myocardial and renal NF-kB expression in preclinical models of doxorubicin cardiotoxicity through NLRP3 and Myd-88 Open
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Ricerca Corrente, Ministero della Salute. Background Doxorubicin-mediated adverse cardiovascular events are among the leading…
View article: P-747 Chromosomal mosaic characteristics among women under IVF treatment: multicentric study of 2282 mosaic embryos diagnosed by preimplantation genetic testing with trophectoderm biopsy
P-747 Chromosomal mosaic characteristics among women under IVF treatment: multicentric study of 2282 mosaic embryos diagnosed by preimplantation genetic testing with trophectoderm biopsy Open
Study question Which chromosomal mosaic features do women under IVF treatment show? Summary answer Single aneuploidies were the most represented among mosaic embryos and their frequency as well as the level of mosaicism increased in older …