Michele A. Bertocci
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View article: Lactate flux dysfunction in patients with bipolar disorder: preliminary insights from ultra-high field 7T MRSI during task and rest
Lactate flux dysfunction in patients with bipolar disorder: preliminary insights from ultra-high field 7T MRSI during task and rest Open
Introduction The symptoms of bipolar disorder (BD) may be characterized as disruptions in energy metabolism, and neural energy availability may serve as a mechanistic marker of BD. Lactate, the end product of glycolysis, is a poorly unders…
View article: Gray Matter Differences in Adolescent Psychiatric Inpatients: A Machine Learning Study of Bipolar Disorder and Other Psychopathologies
Gray Matter Differences in Adolescent Psychiatric Inpatients: A Machine Learning Study of Bipolar Disorder and Other Psychopathologies Open
Background Bipolar disorder (BD) is among the psychiatric disorders most prone to misdiagnosis, with both false positives and false negatives resulting in treatment delay. We employed a whole‐brain machine learning approach focusing on gra…
View article: Differentiating Pediatric Bipolar Disorder, ADHD, and Other Psychopathologies Using Self-Reported Mood/Energy and Actigraphy: Correlation and Machine Learning–Based Prediction of Mood Severity (Preprint)
Differentiating Pediatric Bipolar Disorder, ADHD, and Other Psychopathologies Using Self-Reported Mood/Energy and Actigraphy: Correlation and Machine Learning–Based Prediction of Mood Severity (Preprint) Open
View article: Maximum and minimum activity in inpatient adolescents with Bipolar Disorders: Daily-Variability classification of actigraphy pattern with artificial intelligence
Maximum and minimum activity in inpatient adolescents with Bipolar Disorders: Daily-Variability classification of actigraphy pattern with artificial intelligence Open
Measures of daily activity may be objective markers to help differentiate adolescent bipolar disorder (BD). We used chart reviewed actigraphy data collected from 2014 to 2023, and AI methods to classify well-characterized inpatient adolesc…
View article: Reproducible Effects of Sex and Acquisition Order on Multiple Global Signal Metrics: Implications for Functional Connectivity Studies of Phenotypic Individual Differences Using fMRI
Reproducible Effects of Sex and Acquisition Order on Multiple Global Signal Metrics: Implications for Functional Connectivity Studies of Phenotypic Individual Differences Using fMRI Open
Purpose The identification of relationships between individual differences in functional connectivity (FC) and behavior has been the focus of considerable investigation. Although emerging evidence has identified relationships between FC an…
View article: Weighing the predictive role of neural factors for adolescent anhedonia in the presence of demographic and clinical factors
Weighing the predictive role of neural factors for adolescent anhedonia in the presence of demographic and clinical factors Open
View article: Inter-network Effective Connectivity During An Emotional Working Memory Task in Two Independent Samples of Young Adults
Inter-network Effective Connectivity During An Emotional Working Memory Task in Two Independent Samples of Young Adults Open
This study highlights the different patterns of DMN→CEN EC in conditions with high and low WM loads with and without ER, suggesting that in higher WM loads with ER, the integration of the DMN with the CEN is reduced to facilitate successfu…
View article: Addressing Zero-Inflated Scores in Self-Reported Psychiatric Questionnaires: Utilizing Synthetic Minority Over-Sampling Technique (SMOTE) to Classify Mood and Energy Based on Extreme Activity Levels for Adolescents with Bipolar and ADHD
Addressing Zero-Inflated Scores in Self-Reported Psychiatric Questionnaires: Utilizing Synthetic Minority Over-Sampling Technique (SMOTE) to Classify Mood and Energy Based on Extreme Activity Levels for Adolescents with Bipolar and ADHD Open
Accurate classification of bipolar disorder (BD) and attention deficit hyperactivity disorder (ADHD) in adolescents is challenging due to symptom overlap and the prevalence of zero-inflated bias in self-report questionnaires. This study te…
View article: Examining relationships among NODDI indices of white matter structure in prefrontal cortical-thalamic-striatal circuitry and OCD symptomatology
Examining relationships among NODDI indices of white matter structure in prefrontal cortical-thalamic-striatal circuitry and OCD symptomatology Open
View article: Identifying tripartite relationship among cortical thickness, neuroticism, and mood and anxiety disorders
Identifying tripartite relationship among cortical thickness, neuroticism, and mood and anxiety disorders Open
View article: Neural markers of mania that distinguish inpatient adolescents with bipolar disorder from those with other psychopathology
Neural markers of mania that distinguish inpatient adolescents with bipolar disorder from those with other psychopathology Open
View article: Patterns of Neural Network Functional Connectivity Associated With Mania/Hypomania and Depression Risk in 3 Independent Young Adult Samples
Patterns of Neural Network Functional Connectivity Associated With Mania/Hypomania and Depression Risk in 3 Independent Young Adult Samples Open
Importance Mania/hypomania is the pathognomonic feature of bipolar disorder (BD). Established, reliable neural markers denoting mania/hypomania risk to help with early risk detection and diagnosis and guide the targeting of pathophysiologi…
View article: Neural Network Functional Interactions Mediate or Suppress White Matter–Emotional Behavior Relationships in Infants
Neural Network Functional Interactions Mediate or Suppress White Matter–Emotional Behavior Relationships in Infants Open
View article: Altered patterns of central executive, default mode and salience network activity and connectivity are associated with current and future depression risk in two independent young adult samples
Altered patterns of central executive, default mode and salience network activity and connectivity are associated with current and future depression risk in two independent young adult samples Open
View article: Left ventrolateral prefrontal cortical activity during reward expectancy predicts mania risk up to one year post scan
Left ventrolateral prefrontal cortical activity during reward expectancy predicts mania risk up to one year post scan Open
View article: White Matter Correlates of Early-Onset Bipolar Illness and Predictors of One-Year Recurrence of Depression in Adults with Bipolar Disorder
White Matter Correlates of Early-Onset Bipolar Illness and Predictors of One-Year Recurrence of Depression in Adults with Bipolar Disorder Open
Diffusion Magnetic Resonance Imaging (dMRI) studies have reported abnormalities in emotion regulation circuits in BD; however, no study has examined the contribution of previous illness on these mechanisms. Using global probabilistic tract…
View article: White matter predictors of worsening of subthreshold hypomania severity in non-bipolar young adults parallel abnormalities in individuals with bipolar disorder
White matter predictors of worsening of subthreshold hypomania severity in non-bipolar young adults parallel abnormalities in individuals with bipolar disorder Open
View article: Informing the study of suicidal thoughts and behaviors in distressed young adults: The use of a machine learning approach to identify neuroimaging, psychiatric, behavioral, and demographic correlates
Informing the study of suicidal thoughts and behaviors in distressed young adults: The use of a machine learning approach to identify neuroimaging, psychiatric, behavioral, and demographic correlates Open
View article: Differentiating white matter measures that protect against vs. predispose to bipolar disorder and other psychopathology in at-risk youth
Differentiating white matter measures that protect against vs. predispose to bipolar disorder and other psychopathology in at-risk youth Open
Bipolar disorder (BD) is highly heritable. Identifying objective biomarkers reflecting pathophysiological processes predisposing to, versus protecting against BD, can help identify BD risk in offspring of BD parents. We recruited 21 BD par…
View article: Neural function during emotion regulation and future depressive symptoms in youth at risk for affective disorders
Neural function during emotion regulation and future depressive symptoms in youth at risk for affective disorders Open
View article: A specific neural substrate predicting current and future impulsivity in young adults
A specific neural substrate predicting current and future impulsivity in young adults Open
Impulsivity (rash action with deleterious outcomes) is common to many psychiatric disorders. While some studies indicate altered amygdala and prefrontal cortical (PFC) activity associated with impulsivity, it remains unclear whether these …
View article: Trauma Affects Prospective Relationships Between Reward-Related Ventral Striatal and Amygdala Activation and 1-Year Future Hypo/Mania Trajectories
Trauma Affects Prospective Relationships Between Reward-Related Ventral Striatal and Amygdala Activation and 1-Year Future Hypo/Mania Trajectories Open
View article: White Matter Structure in Youth With Behavioral and Emotional Dysregulation Disorders: A Probabilistic Tractographic Study
White Matter Structure in Youth With Behavioral and Emotional Dysregulation Disorders: A Probabilistic Tractographic Study Open
Psychiatric disorders in youth characterized by behavioral and emotional dysregulation are often comorbid and difficult to distinguish. An alternative approach to conceptualizing these disorders is to move toward a diagnostic system based …
View article: Emotional regulation neural circuitry abnormalities in adult bipolar disorder: dissociating effects of long-term depression history from relationships with present symptoms
Emotional regulation neural circuitry abnormalities in adult bipolar disorder: dissociating effects of long-term depression history from relationships with present symptoms Open
View article: Depression and anxiety mediate the relationship between frontotemporal white matter integrity and quality of life in distressed young adults
Depression and anxiety mediate the relationship between frontotemporal white matter integrity and quality of life in distressed young adults Open
View article: White Matter Correlates of Suicidality in Adults With Bipolar Disorder Who Have Been Prospectively Characterized Since Childhood
White Matter Correlates of Suicidality in Adults With Bipolar Disorder Who Have Been Prospectively Characterized Since Childhood Open
View article: Limbic white matter structural integrity at 3 months prospectively predicts negative emotionality in 9-month-old infants: a preliminary study
Limbic white matter structural integrity at 3 months prospectively predicts negative emotionality in 9-month-old infants: a preliminary study Open
View article: The impact of familial risk and early life adversity on emotion and reward processing networks in youth at-risk for bipolar disorder
The impact of familial risk and early life adversity on emotion and reward processing networks in youth at-risk for bipolar disorder Open
A recently developed risk calculator for bipolar disorder (BD) accounts for clinical and parental psychopathology. Yet, it is understood that both familial predisposition and early life adversity contribute to the development of BD. How th…
View article: Assessing Relationships Among Impulsive Sensation Seeking, Reward Circuitry Activity, and Risk for Psychopathology: A Functional Magnetic Resonance Imaging Replication and Extension Study
Assessing Relationships Among Impulsive Sensation Seeking, Reward Circuitry Activity, and Risk for Psychopathology: A Functional Magnetic Resonance Imaging Replication and Extension Study Open
View article: The impact of targeted cathodal transcranial direct current stimulation on reward circuitry and affect in Bipolar Disorder
The impact of targeted cathodal transcranial direct current stimulation on reward circuitry and affect in Bipolar Disorder Open