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View article: Serum IL-8 as a Determinant of Response to Phosphodiesterase-4 Inhibition in Chronic Obstructive Pulmonary Disease
Serum IL-8 as a Determinant of Response to Phosphodiesterase-4 Inhibition in Chronic Obstructive Pulmonary Disease Open
Rationale: Phosphodiesterase-4 (PDE4) inhibitors have demonstrated increased efficacy in patients with chronic obstructive pulmonary disease who had chronic bronchitis or higher blood eosinophil counts. Further characterization of patients…
View article: A Novel Processing-Free Method for RNAseq Analysis of Spontaneous Sputum in Chronic Obstructive Pulmonary Disease
A Novel Processing-Free Method for RNAseq Analysis of Spontaneous Sputum in Chronic Obstructive Pulmonary Disease Open
Background: Assessments of airways inflammation in patients with chronic obstructive pulmonary disease (COPD) require semi-invasive procedures and specialized sample processing know-how. In this study we aimed to set up and validate a nove…
View article: Metabolomic Characterization of Commercial, Old, and Red-Fleshed Apple Varieties
Metabolomic Characterization of Commercial, Old, and Red-Fleshed Apple Varieties Open
In this study, a metabolomic investigation was presented to correlate single polyphenolic compounds in apple pulp with quality characteristics such as antioxidant activity and content of phenolic compounds and anthocyanins in apple skin. S…
View article: Multi‐chemical analysis combined with chemometrics to characterize <scp>PDO</scp> and <scp>PGI</scp> Italian apples
Multi‐chemical analysis combined with chemometrics to characterize <span>PDO</span> and <span>PGI</span> Italian apples Open
BACKGROUND The use of PDO (protected designation of origin) and PGI (protected geographical indication) labels allows to protect and promote agricultural products characterized by unique features related to the place of origin and traditio…
View article: COPD patients with chronic bronchitis and higher sputum eosinophil counts show increased type‐2 and PDE4 gene expression in sputum
COPD patients with chronic bronchitis and higher sputum eosinophil counts show increased type‐2 and PDE4 gene expression in sputum Open
Chronic obstructive pulmonary disease (COPD) patients with higher eosinophil counts are associated with increased clinical response to phosphodiesterase‐4‐inhibitors (PDE4i). However, the underlying inflammatory mechanisms associated with …
View article: Sr isotope composition of Golden Delicious apples in Northern Italy reflects the soil <scp><sup>87</sup>Sr</scp>/<scp><sup>86</sup>Sr</scp> ratio of the cultivation area
Sr isotope composition of Golden Delicious apples in Northern Italy reflects the soil <span><sup>87</sup>Sr</span>/<span><sup>86</sup>Sr</span> ratio of the cultivation area Open
BACKGROUND Apples have a leading role in the Italian fruit sector, and high‐quality apples, including the Golden Delicious variety, are cultivated mainly in the Northern mountain districts. In the present study, Golden Delicious apples fro…
View article: Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines
Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines Open
We describe a set of benzisothiazolinone (BTZ) derivatives that are potent inhibitors of monoacylglycerol lipase (MGL), the primary degrading enzyme for the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG). Structure-activity relationship…
View article: Foliar Applications of Biostimulants Promote Growth, Yield and Fruit Quality of Strawberry Plants Grown under Nutrient Limitation
Foliar Applications of Biostimulants Promote Growth, Yield and Fruit Quality of Strawberry Plants Grown under Nutrient Limitation Open
Biostimulants have been found effective in enhancing plant resistance toward stressful conditions. The aim of the present study was to evaluate the efficacy of selected biostimulants to overcome the negative effects of nutrient limitation …
View article: Intra- and Intertree Variability of the <sup>87</sup>Sr/<sup>86</sup>Sr Ratio in Apple Orchards and Its Correlation with the Soil <sup>87</sup>Sr/<sup>86</sup>Sr Ratio
Intra- and Intertree Variability of the <sup>87</sup>Sr/<sup>86</sup>Sr Ratio in Apple Orchards and Its Correlation with the Soil <sup>87</sup>Sr/<sup>86</sup>Sr Ratio Open
The 87Sr/86Sr ratio of horticultural products mostly derives from that of the bioavailable Sr fraction of the soil where they grow and, therefore, varies according to the local geolithological features. This study investigated the intra- a…
View article: Use of Biostimulants for Organic Apple Production: Effects on Tree Growth, Yield, and Fruit Quality at Harvest and During Storage
Use of Biostimulants for Organic Apple Production: Effects on Tree Growth, Yield, and Fruit Quality at Harvest and During Storage Open
The experiment was conducted during two consecutive seasons (years 2016 and 2017) in an organic apple orchard of the cultivar Jonathan. Several biostimulants were tested (10 in total), including humic acids, macro and micro seaweed extract…
View article: Ascorbic acid content in apple pulp, peel, and monovarietal cloudy juices of 64 different cultivars
Ascorbic acid content in apple pulp, peel, and monovarietal cloudy juices of 64 different cultivars Open
The present work was designed to compare the vitamin C (ascorbic acid, AsA) content of pulp, peel, and juice of 64 apple cultivars. These cultivars were carefully identified as true to type' by molecular genetic tools, grown in the same si…
View article: Free-energy studies reveal a possible mechanism for oxidation-dependent inhibition of MGL
Free-energy studies reveal a possible mechanism for oxidation-dependent inhibition of MGL Open
The function of monoacylglycerol lipase (MGL), a key actor in the hydrolytic deactivation of the endocannabinoid 2-arachidonoyl- sn -glycerol (2AG), is tightly controlled by the cell’s redox state: oxidative signals such as hydrogen peroxi…