Michele Stanislaw Milella
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View article: Incidence of non-colorectal/endometrial malignancies in individuals with Lynch syndrome: a retrospective cohort study
Incidence of non-colorectal/endometrial malignancies in individuals with Lynch syndrome: a retrospective cohort study Open
View article: Prognostic and predictive implications of tumor suppressor gene alterations in non-small cell lung cancer
Prognostic and predictive implications of tumor suppressor gene alterations in non-small cell lung cancer Open
In addition to identifying alterations suitable for molecularly targeted therapy (TT), comprehensive genomic profiling (CGP) may convey prognostic/predictive information in advanced non-small-cell lung cancer (aNSCLC). We investigated the …
View article: Hydatidiform Mole with Coexisting Normal Pregnancy: A Systematic Review and Individual Participant Data Meta-Analysis
Hydatidiform Mole with Coexisting Normal Pregnancy: A Systematic Review and Individual Participant Data Meta-Analysis Open
Background and Objectives: This study aimed to evaluate obstetric, neonatal, and oncologic outcomes of pregnancies complicated by a hydatidiform mole coexisting with a live fetus (HMCF) carried beyond viability, and to assess the impact of…
View article: Impact of exercise in patients with pancreatic cancer across different treatment phases: A systematic review
Impact of exercise in patients with pancreatic cancer across different treatment phases: A systematic review Open
Although physical exercise may ameliorate sequelae of pancreatic cancer, further investigation is necessary to understand the real impact of exercise medicine interventions in this population and across different treatment phases.
View article: Interleukin-8 as a potential prognostic biomarker in renal cell carcinoma: a systematic review and meta-analysis
Interleukin-8 as a potential prognostic biomarker in renal cell carcinoma: a systematic review and meta-analysis Open
Background and Objective Interleukin-8 (IL-8) is a chemokine involved in inflammation and primary immune response, playing a key role in recruiting neutrophils. IL-8 is produced by several cell types, including immune cells and certain can…
View article: Effect of exercise on bone-related outcomes in patients with cancer affected by bone metastases or bone loss: a systematic review and meta-analysis
Effect of exercise on bone-related outcomes in patients with cancer affected by bone metastases or bone loss: a systematic review and meta-analysis Open
Our results suggest that, while exercise does not significantly increase BMD in patients with cancer and bone impairments when added to standard therapies, there are important variations across studies. High-intensity resistance and impact…
View article: Risk factors for intoxications in the workplace: a case-control study on data from the Poison Control Center of Policlinico Umberto I of Rome
Risk factors for intoxications in the workplace: a case-control study on data from the Poison Control Center of Policlinico Umberto I of Rome Open
Background. The term intoxication refers to the disease, acute or chronic, caused by harmful substances or those made harmful due to factors such as high concentration or impaired immune defenses. These substances can cause reversible or i…
View article: The Medical Impact of Hepatitis D Virus Infection in Natives and Immigrants: The Italian Paradigm
The Medical Impact of Hepatitis D Virus Infection in Natives and Immigrants: The Italian Paradigm Open
Background and Aim Ongoing migratory flows are reconstituting the hepatitis D virus (HDV) reservoir in Italy. We aimed to characterise the current clinical and virologic features of HDV infection in both native Italians and migrants. Metho…
View article: A procedure to identify persistent and effort‐independent individual differences in preference for heroin over rewarding social interaction
A procedure to identify persistent and effort‐independent individual differences in preference for heroin over rewarding social interaction Open
Background and Purpose In some individuals, opioid use leads to decreased interest in socially relevant rewards. Recent studies showed that after extended‐access heroin self‐administration, rats strongly prefer social interaction over sing…
View article: Meta-Analysis Exploring Tyrosine Kinase Inhibitor-Induced Weight Gain in Oncogene-Addicted NSCLC
Meta-Analysis Exploring Tyrosine Kinase Inhibitor-Induced Weight Gain in Oncogene-Addicted NSCLC Open
Our findings confirmed the unique profile of lorlatinib regarding weight gain, regardless of patient characteristics. Considering the impressive prognostic horizons achievable with TKIs in oncogene-addicted NSCLC, adequate reporting in cli…
View article: Cardiac autonomic dysfunction in patients with cancer: exploring the role of physical exercise
Cardiac autonomic dysfunction in patients with cancer: exploring the role of physical exercise Open
While research on the effects of physical exercise on autonomic modulation in cancer patients is still limited, early findings show promise. Further studies are needed to fully understand the mechanisms through which exercise improves card…
View article: Mucinous cystic neoplasms and simple mucinous cysts are two distinct precursors of pancreatic cancer: clinicopathological, genomic, and transcriptomic characterization
Mucinous cystic neoplasms and simple mucinous cysts are two distinct precursors of pancreatic cancer: clinicopathological, genomic, and transcriptomic characterization Open
Mucinous cystic neoplasms (MCNs) of the pancreas are macroscopic precursors of pancreatic cancer. A similar cystic lesion but lacking the ovarian‐type subepithelial stroma has been recently defined as a simple mucinous cyst (SMC); however,…
View article: Bisphenol A drives nuclear factor-kappa B signaling activation and enhanced motility in non-transformed breast cells
Bisphenol A drives nuclear factor-kappa B signaling activation and enhanced motility in non-transformed breast cells Open
View article: A novel procedure to identify persistent and effort-independent individual differences in preference for heroin over rewarding social interaction
A novel procedure to identify persistent and effort-independent individual differences in preference for heroin over rewarding social interaction Open
View article: Behavioural and pharmacokinetic analysis of heroin and cocaine self‐administration: Effects of timeout on self‐administration and choice in male rats
Behavioural and pharmacokinetic analysis of heroin and cocaine self‐administration: Effects of timeout on self‐administration and choice in male rats Open
Background and Purpose Heroin and cocaine users tailor their dosage, frequency and administration route to maximise the drugs' effects or prevent withdrawal symptoms. Counterintuitively, preclinical self‐administration and choice experimen…
View article: Clinical outcomes of avelumab and pembrolizumab in advanced urothelial cancer: an observational multicenter retro-prospective study on patients undergoing treatment in clinical practice (AVePEm study)
Clinical outcomes of avelumab and pembrolizumab in advanced urothelial cancer: an observational multicenter retro-prospective study on patients undergoing treatment in clinical practice (AVePEm study) Open
Introduction and objectives Patients (pts) with metastatic urothelial carcinoma (mUC) gain substantial benefit from immunotherapy exposure. If they do not experience disease progression after 4-6 cycles of first-line platinum-based chemoth…
View article: Quantification of [<sup>11</sup>C]ABP688 Binding to mGluR5 in Human Brain using Cerebellum as Reference Region: Biological Interpretation and Limitations
Quantification of [<sup>11</sup>C]ABP688 Binding to mGluR5 in Human Brain using Cerebellum as Reference Region: Biological Interpretation and Limitations Open
Introduction: In vitro data from primates provide conflicting evidence about the suitability of the cerebellum as a reference region for quantifying type 5 metabotropic glutamate receptor (mGluR5) binding parameters with positron emission …
View article: Expanding Lynch Syndrome Spectrum: The Role of Non-Colorectal/Endometrial Malignancies and Implications for Universal Tumor Screening
Expanding Lynch Syndrome Spectrum: The Role of Non-Colorectal/Endometrial Malignancies and Implications for Universal Tumor Screening Open
View article: Safety of Sofosbuvir-Based Direct-Acting Antivirals for Hepatitis C Virus Infection and Direct Oral Anticoagulant Co-Administration
Safety of Sofosbuvir-Based Direct-Acting Antivirals for Hepatitis C Virus Infection and Direct Oral Anticoagulant Co-Administration Open
Background: Direct oral anticoagulants (DOACs) are recommended for the management of thrombosis prophylaxis, especially in patients with atrial fibrillation. As substrates of cytochrome P450 (CYP) 3A4 and/or P-glycoprotein, they are implic…
View article: Glucagon-Producing Pancreatic Neuroendocrine Tumors (Glucagonomas) are Enriched in Aggressive Neoplasms with ARX and PDX1 Co-expression, DAXX/ATRX Mutations, and ALT (Alternative Lengthening of Telomeres)
Glucagon-Producing Pancreatic Neuroendocrine Tumors (Glucagonomas) are Enriched in Aggressive Neoplasms with ARX and PDX1 Co-expression, DAXX/ATRX Mutations, and ALT (Alternative Lengthening of Telomeres) Open
View article: Randomized phase 2 study of valproic acid combined with simvastatin and gemcitabine/nab-paclitaxel-based regimens in untreated metastatic pancreatic adenocarcinoma patients: the VESPA trial study protocol
Randomized phase 2 study of valproic acid combined with simvastatin and gemcitabine/nab-paclitaxel-based regimens in untreated metastatic pancreatic adenocarcinoma patients: the VESPA trial study protocol Open
View article: Long-Term Survivor of Intrahepatic Cholangiocarcinoma for over 18 Years: Case Study with Longitudinal Histo-molecular and Tumor Immune Microenvironment Characterization and Systematic Review of the Literature
Long-Term Survivor of Intrahepatic Cholangiocarcinoma for over 18 Years: Case Study with Longitudinal Histo-molecular and Tumor Immune Microenvironment Characterization and Systematic Review of the Literature Open
View article: Case report: Male genital system, soft tissue and myocardial metastases in a patient with exon 11-mutated GIST of unknown origin
Case report: Male genital system, soft tissue and myocardial metastases in a patient with exon 11-mutated GIST of unknown origin Open
Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal tumors of the gastrointestinal tract, usually arising in the stomach or in the small bowel. Most GISTs are diagnosed early due to the presence of symptoms (e.g., abd…
View article: Tissue- and liquid-biopsy based NGS profiling in advanced non-small-cell lung cancer in a real-world setting: the IMMINENT study
Tissue- and liquid-biopsy based NGS profiling in advanced non-small-cell lung cancer in a real-world setting: the IMMINENT study Open
Introduction To date, for all non-small cell lung cancer (NSCLC) cases, it is recommended to test for driver alterations to identify actionable therapeutic targets. In this light, comprehensive genomic profiling (CGP) with next generation …
View article: Review of: "Exploring the Experiences and Perceptions of Young People’s Recreational Nitrous Oxide Use"
Review of: "Exploring the Experiences and Perceptions of Young People’s Recreational Nitrous Oxide Use" Open
View article: Bisphenol-A in Drinking Water Accelerates Mammary Cancerogenesis and Favors an Immunosuppressive Tumor Microenvironment in BALB–neuT Mice
Bisphenol-A in Drinking Water Accelerates Mammary Cancerogenesis and Favors an Immunosuppressive Tumor Microenvironment in BALB–neuT Mice Open
Bisphenol-A (BPA), a synthetic compound ubiquitously present in the environment, can act as an endocrine disruptor by binding to both canonical and non-canonical estrogen receptors (ERs). Exposure to BPA has been linked to various cancers,…
View article: Treatment of Locally Advanced Rectal Cancer in the Era of Total Neoadjuvant Therapy
Treatment of Locally Advanced Rectal Cancer in the Era of Total Neoadjuvant Therapy Open
Importance Treatment of locally advanced rectal cancer (LARC) involves neoadjuvant chemoradiotherapy plus total mesorectal excision and adjuvant chemotherapy. However, total neoadjuvant therapy (TNT) protocols (ie, preoperative chemotherap…
View article: A holistic evaluation of patients with chronic Hepatitis D virus (HDV) infection enrolled in the Italian PITER-B and delta cohort
A holistic evaluation of patients with chronic Hepatitis D virus (HDV) infection enrolled in the Italian PITER-B and delta cohort Open
View article: Quantification of [<sup>11</sup>C]ABP688 binding in human brain using cerebellum as reference region: biological interpretation and limitations
Quantification of [<sup>11</sup>C]ABP688 binding in human brain using cerebellum as reference region: biological interpretation and limitations Open
In vitro data from primates provide conflicting evidence about the cerebellum’s suitability as a reference region for quantifying type 5 metabotropic glutamate receptor (mGluR5) binding parameters with positron emission tomography (PET). T…
View article: The endocrine disruptor cadmium modulates the androgen–estrogen receptors ratio and induces inflammatory cytokines in luminal (A) cell models of breast cancer
The endocrine disruptor cadmium modulates the androgen–estrogen receptors ratio and induces inflammatory cytokines in luminal (A) cell models of breast cancer Open
Purpose Breast cancer (BC) is the most common malignancy that affects women, and it is, to date, their leading cause of death. Luminal A molecular subtype accounts for 40% of BC and is characterized by hormone receptors positive/human epid…