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View article: Fibromuscular Dysplasia and Spontaneous Cervical Artery Dissection
Fibromuscular Dysplasia and Spontaneous Cervical Artery Dissection Open
Importance Fibromuscular dysplasia (FMD) is found in 6 to 14% of patients with spontaneous cervical artery dissection (SCEAD) and may be associated with recurrent SCEAD. Objective To evaluate the correlates of FMD in patients with SCEAD an…
View article: Intravenous thrombolysis in patients with acute ischaemic stroke and active cancer (the ITACA-stroke study)
Intravenous thrombolysis in patients with acute ischaemic stroke and active cancer (the ITACA-stroke study) Open
View article: Peripheral blood mononuclear cell secretome from patients with autoimmune encephalitis promotes seizures in vitro
Peripheral blood mononuclear cell secretome from patients with autoimmune encephalitis promotes seizures in vitro Open
Objective Autoimmune encephalitis (AE) is characterized by inflammatory processes in the central nervous system and frequently presents with seizures. Even though an ictogenic potential has been shown for some antibodies against neuronal s…
View article: Editor’s Pick: Precision Medicine in Neurology: Advancing Care for Female Patients
Editor’s Pick: Precision Medicine in Neurology: Advancing Care for Female Patients Open
Growing evidence suggests that biological sex influences disease risk, clinical presentation, treatment response, and prognosis across neurological conditions. Despite this increasing awareness of important sex differences, neurological re…
View article: Characteristics and causes of recurrent ischemic events in minor ischemic stroke and TIA in the READAPT study
Characteristics and causes of recurrent ischemic events in minor ischemic stroke and TIA in the READAPT study Open
Patients with recurrences after a minor stroke or high-risk TIA have a different etiologic distribution compared with their index events. Additionally, a lower compliance to DAPT was observed in those with recurrences, suggesting that adhe…
View article: Patient-centred estimation of multimorbidity in chronic disease populations: a novel approach integrating global burden of disease metrics and healthcare administrative data
Patient-centred estimation of multimorbidity in chronic disease populations: a novel approach integrating global burden of disease metrics and healthcare administrative data Open
View article: Thrombotic events after vaccination for covid-19 in Italy: a report from the Italian society on thrombosis and haemostasis registry
Thrombotic events after vaccination for covid-19 in Italy: a report from the Italian society on thrombosis and haemostasis registry Open
Since vaccine induced immune thrombotic thrombocytopenia (VITT) became evident in early 2021, research has focused on characterizing this new pathologic entity. Moreover, data were urgently needed on the association, if any, between all CO…
View article: Intravenous Thrombolysis in Patients With Recent Intake of Direct Oral Anticoagulants: A Target Trial Analysis and Comparison With Reversal Agent Use
Intravenous Thrombolysis in Patients With Recent Intake of Direct Oral Anticoagulants: A Target Trial Analysis and Comparison With Reversal Agent Use Open
BACKGROUND: Intravenous thrombolysis (IVT) in patients with recent ingestion of direct oral anticoagulants (DOACs) is a frequent challenge and remains controversial. The benefit of DOAC reversal before IVT is uncertain. METHODS: Using targ…
View article: Effect of levetiracetam on cognition in patients with cognitive decline: A systematic review and meta‐analysis of randomized controlled trials
Effect of levetiracetam on cognition in patients with cognitive decline: A systematic review and meta‐analysis of randomized controlled trials Open
We conducted a systematic review and meta‐analysis of randomized controlled trials (RCTs) evaluating the efficacy of levetiracetam (LEV) compared to placebo in improving cognitive performance in people with cognitive decline. The protocol …
View article: Prognostic Value of Cerebral Hemodynamics Assessment on 24‐h Transcranial Color‐Coded Doppler Following a Successful Thrombectomy
Prognostic Value of Cerebral Hemodynamics Assessment on 24‐h Transcranial Color‐Coded Doppler Following a Successful Thrombectomy Open
Background and Aims This study evaluates the distribution and prognostic role of transcranial color‐coded Doppler (TCCD) spectral patterns following a successful endovascular thrombectomy (EVT). Methods This multicenter prospective study i…
View article: Antithrombotic Trends Before and After Publication of Randomized Clinical Trials in Cervical Artery Dissection: A Secondary Analysis of the STOP‐CAD Study
Antithrombotic Trends Before and After Publication of Randomized Clinical Trials in Cervical Artery Dissection: A Secondary Analysis of the STOP‐CAD Study Open
Background Two randomized clinical trials have failed to demonstrate the superiority of anticoagulation over antiplatelet therapy in acute cervical artery dissection, with many patients still receiving anticoagulation despite bleeding risk…
View article: Recurrent stroke in patients with history of stroke/transient ischemic attack and device-detected atrial fibrillation: A systematic review and meta-analysis
Recurrent stroke in patients with history of stroke/transient ischemic attack and device-detected atrial fibrillation: A systematic review and meta-analysis Open
Introduction: Prolonged cardiac monitoring after stroke increases the detection of device-detected atrial fibrillation (DDAF), leading to a clinical dilemma regarding anticoagulation for secondary stroke prevention. While anticoagulation r…
View article: Effectiveness and safety of dual antiplatelet therapy in patients with minor ischemic stroke or transient ischemic attack and cancer: A secondary analysis of the READAPT study
Effectiveness and safety of dual antiplatelet therapy in patients with minor ischemic stroke or transient ischemic attack and cancer: A secondary analysis of the READAPT study Open
Introduction: Patients with ischemic stroke or transient ischemic attack (TIA) and cancer face unique risks of recurrent ischemic events and bleeding. It is unclear whether this increased risk is present even in patients with minor ischemi…
View article: Real‐World Dual Antiplatelet Therapy Use Exceeds Randomized Trials Boundaries With Possible Safety Issues in Patients With Large Artery Atherosclerosis—Insights From the <scp>READAPT</scp> Study
Real‐World Dual Antiplatelet Therapy Use Exceeds Randomized Trials Boundaries With Possible Safety Issues in Patients With Large Artery Atherosclerosis—Insights From the <span>READAPT</span> Study Open
Background and Aim According to randomized controlled trials (RCTs), dual antiplatelet therapy (DAPT) is more effective for secondary prevention of ischemic events attributable to large artery atherosclerosis (LAA) than other mechanisms. W…
View article: Do antithrombotic drugs have a role in migraine prevention? A systematic review
Do antithrombotic drugs have a role in migraine prevention? A systematic review Open
Objectives To explore the available evidence on the role of antithrombotics as migraine preventive medication. Background In clinical practice, the use of antithrombotic drugs in individuals with migraine is sometimes considered, especiall…
View article: Correction: One-year outcome and quality of life of patients with subarachnoid hemorrhage admitted to intensive care unit: a single-center retrospective pilot study
Correction: One-year outcome and quality of life of patients with subarachnoid hemorrhage admitted to intensive care unit: a single-center retrospective pilot study Open
View article: Epilepsy Stands Nearby: A Pilot CT Perfusion Study on Post‐Stroke Non‐Convulsive Status Epilepticus
Epilepsy Stands Nearby: A Pilot CT Perfusion Study on Post‐Stroke Non‐Convulsive Status Epilepticus Open
Background To investigate the relevance of hyperperfusion on computerised perfusion imaging (CTP) in the emergency setting in people with non‐convulsive status epilepticus (NCSE) and previous stroke, to derive relevant aspects on the epile…
View article: Aura phenomenon: a proposal for an etiology-based clinical classification
Aura phenomenon: a proposal for an etiology-based clinical classification Open
This nuanced classification aims to aid in the diagnostic evaluation and phenotyping of aura phenomenon, ultimately improving the diagnosis and management of the different associated neurological conditions. Moreover, it could promote effe…
View article: Statin therapy in ischemic stroke patients with atrial fibrillation: Efficacy and safety outcomes
Statin therapy in ischemic stroke patients with atrial fibrillation: Efficacy and safety outcomes Open
Introduction: The efficacy and safety of statins for secondary prevention in patients who have experienced a cardioembolic stroke are not well-defined. However, previous observational data reported hyperlipidemia as a risk factor for both …
View article: Admission systolic blood pressure and short-term outcomes after dual antiplatelet therapy in patients with minor ischemic stroke or transient ischemic attack
Admission systolic blood pressure and short-term outcomes after dual antiplatelet therapy in patients with minor ischemic stroke or transient ischemic attack Open
Background: Elevated baseline systolic blood pressure (SBP) was associated with poor outcomes following dual antiplatelet therapy (DAPT) in patients with non-cardioembolic minor ischemic stroke (MIS) or high-risk transient ischemic attack …
View article: Real-world outcomes following dual antiplatelet therapy in mild-to-moderate ischemic stroke with anterior versus posterior circulation infarct: a READAPT study propensity matched analysis
Real-world outcomes following dual antiplatelet therapy in mild-to-moderate ischemic stroke with anterior versus posterior circulation infarct: a READAPT study propensity matched analysis Open
Background: Dual antiplatelet therapy (DAPT) is a cornerstone of secondary prevention in patients with minor ischemic stroke or high-risk transient ischemic attack. The effectiveness and safety of DAPT may differ between patients with post…
View article: Morbimortality Associated Risk in the Treatment of Unruptured Intracranial Aneurysms (Marta) Score: Development and Validation of a Predictive Tool for Complications in Open Neurosurgery and Endovascular Treatment
Morbimortality Associated Risk in the Treatment of Unruptured Intracranial Aneurysms (Marta) Score: Development and Validation of a Predictive Tool for Complications in Open Neurosurgery and Endovascular Treatment Open
View article: Morbimortality Associated Risk in the Treatment of unruptured intracranial Aneurysms (MARTA) Score: development and validation of a predictive tool for complications in open neurosurgery and endovascular treatment.
Morbimortality Associated Risk in the Treatment of unruptured intracranial Aneurysms (MARTA) Score: development and validation of a predictive tool for complications in open neurosurgery and endovascular treatment. Open
View article: Drip and ship in patients with acute ischemic stroke: a narrative review
Drip and ship in patients with acute ischemic stroke: a narrative review Open
Acute ischemic stroke (AIS) is a leading cause of long-term disability and mortality worldwide, necessitating the rapid implementation of time-sensitive reperfusion therapies to improve outcomes. The “drip and ship” (DS) model, in which in…
View article: Prognostic serum biomarkers of synaptic, neuronal and glial injury in patients with acute ischemic stroke of the anterior circulation
Prognostic serum biomarkers of synaptic, neuronal and glial injury in patients with acute ischemic stroke of the anterior circulation Open
Background We aimed to investigate the prognostic role of β‐synuclein in comparison to that of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) for predicting functional outcome after acute ischemic stroke (AIS). …
View article: Prognostic factors and impact of management strategies for status epilepticus: The <scp>STEPPER</scp> study in the Emilia‐Romagna region, Italy
Prognostic factors and impact of management strategies for status epilepticus: The <span>STEPPER</span> study in the Emilia‐Romagna region, Italy Open
Objective The STEPPER (Status Epilepticus in Emilia‐Romagna) study aimed to investigate the clinical characteristics, prognostic factors, and treatment approaches of status epilepticus (SE) in adults of the Emilia‐Romagna region (ERR), Nor…
View article: Exploring Sex Differences in Outcomes of Dual Antiplatelet Therapy for Patients With Noncardioembolic Mild-to-Moderate Ischemic Stroke or High-Risk Transient Ischemic Attack: A Propensity-Matched Analysis of the READAPT Study Cohort
Exploring Sex Differences in Outcomes of Dual Antiplatelet Therapy for Patients With Noncardioembolic Mild-to-Moderate Ischemic Stroke or High-Risk Transient Ischemic Attack: A Propensity-Matched Analysis of the READAPT Study Cohort Open
BACKGROUND: Sex may impact clinical outcomes in patients with stroke treated with dual antiplatelet therapy (DAPT). We aimed to investigate the sex differences in the short-term outcomes of DAPT within a real-world population of patients w…
View article: Incidence and prognosis of first-ever intracerebral hemorrhage on antiplatelet therapy over 10 years in a population-based stroke registry
Incidence and prognosis of first-ever intracerebral hemorrhage on antiplatelet therapy over 10 years in a population-based stroke registry Open
The use of antiplatelet therapy (APT) is prevalent among the general population, sometimes without clear indications. We provided updated figures on the incidence and prognosis of first-ever intracerebral hemorrhage occurring on APT (APT-I…
View article: Stroke thrombectomy in the elderly: A propensity score matched study on a nationwide real-world registry
Stroke thrombectomy in the elderly: A propensity score matched study on a nationwide real-world registry Open
Introduction: Data on safety and efficacy of endovascular thrombectomy (EVT) for acute ischemic stroke in older patients are limited and controversial, and people aged 80 or older were under-represented in randomized trials. Our aim was to…
View article: Defining short-term outcomes of minor ischemic stroke due to small artery occlusion in the era of dual antiplatelet treatment: A READAPT study sub-analysis
Defining short-term outcomes of minor ischemic stroke due to small artery occlusion in the era of dual antiplatelet treatment: A READAPT study sub-analysis Open
Our findings show overall favorable short-term prognosis after SAO-MIS treated with DAPT. Future studies should investigate factors associated with residual stroke risk and long-term outcomes of SAO-MIS.