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View article: Probiotics to reduce ventilator-associated pneumonia in adults with acute non‑anoxic brain injury: Study Protocol for a Double-Blind Multicenter Randomized International Clinical Trial (PROACT)
Probiotics to reduce ventilator-associated pneumonia in adults with acute non‑anoxic brain injury: Study Protocol for a Double-Blind Multicenter Randomized International Clinical Trial (PROACT) Open
Registered at ClinicalTrials.gov (identifier: [NCT06092554]). Registered on 2023-10-15.
View article: Management and monitoring strategies for severe cerebral malaria: a guide for the intensivist
Management and monitoring strategies for severe cerebral malaria: a guide for the intensivist Open
View article: Probiotics to Reduce Ventilator-Associated Pneumonia: Study Protocol for a Double-Blind Multicenter Randomized International Clinical Trial (PROACT)
Probiotics to Reduce Ventilator-Associated Pneumonia: Study Protocol for a Double-Blind Multicenter Randomized International Clinical Trial (PROACT) Open
Background : Ventilator-associated pneumonia (VAP) remains a significant complication among critically ill patients, with associated mortality approaching 50%. Despite the implementation of established preventive strategies, additional int…
View article: Machine Learning and Artificial Intelligence in Intensive Care Medicine: Critical Recalibrations from Rule-Based Systems to Frontier Models
Machine Learning and Artificial Intelligence in Intensive Care Medicine: Critical Recalibrations from Rule-Based Systems to Frontier Models Open
Artificial intelligence (AI) and machine learning (ML) are rapidly transforming clinical decision support systems (CDSSs) in intensive care units (ICUs), where vast amounts of real-time data present both an opportunity and a challenge for …
View article: Beta-Lactam Antibiotic Concentrations and the Acquisition of Multi-Drug Resistant Bacteria in Critically Ill Patients
Beta-Lactam Antibiotic Concentrations and the Acquisition of Multi-Drug Resistant Bacteria in Critically Ill Patients Open
Antimicrobial resistance (AMR) is a worldwide healthcare emergency. Whether insufficient beta-lactam antibiotic concentrations can be associated with AMR emergence remains controversial. This is a retrospective single-center cohort study i…
View article: Immunomodulation in Pediatric Sepsis: A Narrative Review
Immunomodulation in Pediatric Sepsis: A Narrative Review Open
Pediatric sepsis presents a unique clinical challenge due to the distinct characteristics of the developing immune system. The immune response in children differs significantly from that in adults, exhibiting a unique combination of resist…
View article: Impact of fever on the outcome non-anoxic acute brain injury patients: a systematic review and meta-analysis
Impact of fever on the outcome non-anoxic acute brain injury patients: a systematic review and meta-analysis Open
Fever was associated with poor neurological outcomes and mortality in patients with acute brain injury. Whether normothermia should be targeted in the management of all neuro critically ill patients warrants specific research.
View article: The state of artificial intelligence in medical research: A survey of corresponding authors from top medical journals
The state of artificial intelligence in medical research: A survey of corresponding authors from top medical journals Open
Natural Language Processing (NLP) is a subset of artificial intelligence that enables machines to understand and respond to human language through Large Language Models (LLMs)‥ These models have diverse applications in fields such as medic…
View article: Exploring the effects of post operative hyperoxic intermittent stimuli on reticulocyte levels in cancer patients: a randomized controlled study
Exploring the effects of post operative hyperoxic intermittent stimuli on reticulocyte levels in cancer patients: a randomized controlled study Open
Background Anemia is common among hospitalized critically ill and surgical oncological patients. The rising incidence of cancer and aggressive treatments has increased the demand for blood products, further strained by a dwindling donor po…
View article: Circulating Nucleosomes as a Novel Biomarker for Sepsis: A Scoping Review
Circulating Nucleosomes as a Novel Biomarker for Sepsis: A Scoping Review Open
Circulating nucleosome levels are commonly elevated in physiological and pathological conditions. Their potential as biomarkers for diagnosing and prognosticating sepsis remains uncertain due, in part, to technical limitations in existing …
View article: Ketone Bodies after Cardiac Arrest: A Narrative Review and the Rationale for Use
Ketone Bodies after Cardiac Arrest: A Narrative Review and the Rationale for Use Open
Cardiac arrest survivors suffer the repercussions of anoxic brain injury, a critical factor influencing long-term prognosis. This injury is characterised by profound and enduring metabolic impairment. Ketone bodies, an alternative energeti…
View article: Oxidative Stress and Cerebral Vascular Tone: The Role of Reactive Oxygen and Nitrogen Species
Oxidative Stress and Cerebral Vascular Tone: The Role of Reactive Oxygen and Nitrogen Species Open
The brain’s unique characteristics make it exceptionally susceptible to oxidative stress, which arises from an imbalance between reactive oxygen species (ROS) production, reactive nitrogen species (RNS) production, and antioxidant defense …
View article: Pulsed Hyperoxia Acts on Plasmatic Advanced Glycation End Products and Advanced Oxidation Protein Products and Modulates Mitochondrial Biogenesis in Human Peripheral Blood Mononuclear Cells: A Pilot Study on the “Normobaric Oxygen Paradox”
Pulsed Hyperoxia Acts on Plasmatic Advanced Glycation End Products and Advanced Oxidation Protein Products and Modulates Mitochondrial Biogenesis in Human Peripheral Blood Mononuclear Cells: A Pilot Study on the “Normobaric Oxygen Paradox” Open
The “normobaric oxygen paradox” (NOP) describes the response to the return to normoxia after a hyperoxic event, sensed by tissues as an oxygen shortage, up-regulating redox-sensitive transcription factors. We have previously characterized …
View article: Combined depth and scalp electroencephalographic monitoring in acute brain injury: Yield and prognostic value
Combined depth and scalp electroencephalographic monitoring in acute brain injury: Yield and prognostic value Open
Background and purpose Depth electroencephalography (dEEG) is an emerging neuromonitoring technology in acute brain injury (ABI). We aimed to explore the concordances between electrophysiological activities on dEEG and on scalp EEG (scEEG)…
View article: The Impact of Inotropes and Vasopressors on Cerebral Oxygenation in Patients with Traumatic Brain Injury and Subarachnoid Hemorrhage: A Narrative Review
The Impact of Inotropes and Vasopressors on Cerebral Oxygenation in Patients with Traumatic Brain Injury and Subarachnoid Hemorrhage: A Narrative Review Open
Traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH) are critical neurological conditions that necessitate specialized care in the Intensive Care Unit (ICU). Managing cerebral perfusion pressure (CPP) and mean arterial pressure (…
View article: Reactive Oxygen Species (ROS), Reactive Nitrogen Species (RNS), Antioxidants, and Cerebral Vascular Tone
Reactive Oxygen Species (ROS), Reactive Nitrogen Species (RNS), Antioxidants, and Cerebral Vascular Tone Open
The brain's unique characteristics make it exceptionally susceptible to oxidative stress, which arises from an imbalance between reactive oxygen species (ROS) production, reactive nitrogen species (RNS) production, and antioxidant def…
View article: The acute phase management of traumatic spinal cord injury (tSCI) with polytrauma: A narrative review
The acute phase management of traumatic spinal cord injury (tSCI) with polytrauma: A narrative review Open
View article: A glimpse into multimodal neuromonitoring in acute liver failure: a case report
A glimpse into multimodal neuromonitoring in acute liver failure: a case report Open
Introduction: Acute liver failure (ALF) is a rapidly progressing, life-threatening syndrome characterized by liver-related coagulopathy and hepatic encephalopathy (HE). Given that higher HE grades correlate with poorer outcomes, clinical m…
View article: The impact of perfusion computed tomography on the diagnosis and outcome of delayed cerebral ischemia after subarachnoid hemorrhage
The impact of perfusion computed tomography on the diagnosis and outcome of delayed cerebral ischemia after subarachnoid hemorrhage Open
View article: The effect of increased positive end expiratory pressure on brain tissue oxygenation and intracranial pressure in acute brain injury patients
The effect of increased positive end expiratory pressure on brain tissue oxygenation and intracranial pressure in acute brain injury patients Open
View article: Disrupting the “Animal Farm” of scientific research and publishing: AI as an impartial sidekick
Disrupting the “Animal Farm” of scientific research and publishing: AI as an impartial sidekick Open
SCOPUS: le.j
View article: Brain Oxygenation Response to Hypercapnia in Patients with Acute Brain Injury
Brain Oxygenation Response to Hypercapnia in Patients with Acute Brain Injury Open
View article: Artificial intelligence is the new chief editor of Critical Care (maybe?)
Artificial intelligence is the new chief editor of Critical Care (maybe?) Open
SCOPUS: le.j
View article: Cardiac Injury After Traumatic Brain Injury: Clinical Consequences and Management
Cardiac Injury After Traumatic Brain Injury: Clinical Consequences and Management Open
View article: Serum LDH levels may predict poor neurological outcome after aneurysmal subarachnoid hemorrhage
Serum LDH levels may predict poor neurological outcome after aneurysmal subarachnoid hemorrhage Open
View article: Brain Oxygenation Response to Hypercapnia in Acute Brain Injured Patients
Brain Oxygenation Response to Hypercapnia in Acute Brain Injured Patients Open
Background Cerebral hypoxia is a frequent cause of secondary brain damage in patients with acute brain injury. Although hypercapnia can increase intracranial pressure, it may have beneficial effects on tissue oxygenation. We aimed to asses…
View article: Artificial intelligence hallucinations
Artificial intelligence hallucinations Open
SCOPUS: le.j
View article: Noninvasive respiratory support after extubation: a systematic review and network meta-analysis
Noninvasive respiratory support after extubation: a systematic review and network meta-analysis Open
Background The effect of noninvasive respiratory support (NRS), including high-flow nasal oxygen, bi-level positive airway pressure and continuous positive airway pressure (noninvasive ventilation (NIV)), for preventing and treating post-e…
View article: Correction to: Can artificial intelligence help for scientific writing?
Correction to: Can artificial intelligence help for scientific writing? Open
View article: Can artificial intelligence help for scientific writing?
Can artificial intelligence help for scientific writing? Open