Elizabeth M. Bailey
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View article: Antibody surface mobility amplifies FcγR signaling via Arp2/3 during phagocytosis
Antibody surface mobility amplifies FcγR signaling via Arp2/3 during phagocytosis Open
View article: An Optimized Single-Molecule Pull-Down Assay for Quantification of Protein Phosphorylation
An Optimized Single-Molecule Pull-Down Assay for Quantification of Protein Phosphorylation Open
Phosphorylation is a necessary posttranslational modification that regulates protein function and directs cell signaling outcomes. Current methods to measure protein phosphorylation cannot preserve the heterogeneity in phosphorylation acro…
View article: Sterols lower energetic barriers of membrane bending and fission necessary for efficient clathrin-mediated endocytosis
Sterols lower energetic barriers of membrane bending and fission necessary for efficient clathrin-mediated endocytosis Open
View article: Sterols lower energetic barriers of membrane bending and fission necessary for efficient clathrin-mediated endocytosis
Sterols lower energetic barriers of membrane bending and fission necessary for efficient clathrin-mediated endocytosis Open
View article: IgG surface mobility promotes antibody dependent cellular phagocytosis by Syk and Arp2/3 mediated reorganization of Fcγ receptors in macrophages
IgG surface mobility promotes antibody dependent cellular phagocytosis by Syk and Arp2/3 mediated reorganization of Fcγ receptors in macrophages Open
By visualizing the movements of Rituximab during Antibody dependent cellular phagocytosis (ADCP) of B lymphoma cells by macrophages, we found that Fcγ receptors (FcγR) on the macrophage surface microcluster, recruit Syk and undergro large-…
View article: Engineered IgG1-Fc Molecules Define Valency Control of Cell Surface Fcγ Receptor Inhibition and Activation in Endosomes
Engineered IgG1-Fc Molecules Define Valency Control of Cell Surface Fcγ Receptor Inhibition and Activation in Endosomes Open
The inhibition of Fcγ receptors (FcγR) is an attractive strategy for treating diseases driven by IgG immune complexes (IC). Previously, we demonstrated that an engineered tri-valent arrangement of IgG1 Fc domains (SIF1) potently inhibited …
View article: Sterols lower energetic barriers of membrane bending and fission necessary for efficient clathrin mediated endocytosis
Sterols lower energetic barriers of membrane bending and fission necessary for efficient clathrin mediated endocytosis Open
SUMMARY As the principal internalization mechanism in mammalian cells, clathrin-mediated endocytosis (CME) is critical for cellular signal transduction, receptor recycling, and membrane homeostasis. Acute depletion of cholesterol disrupts …
View article: IgG Surface Mobility Promotes Antibody Dependent Cellular Phagocytosis by Syk and Arp2/3 Mediated Reorganization of Macrophage FcγRs
IgG Surface Mobility Promotes Antibody Dependent Cellular Phagocytosis by Syk and Arp2/3 Mediated Reorganization of Macrophage FcγRs Open
View article: Sterols Lower Energetic Barriers of Membrane Bending and Fission Necessary for Efficient Clathrin Mediated Endocytosis
Sterols Lower Energetic Barriers of Membrane Bending and Fission Necessary for Efficient Clathrin Mediated Endocytosis Open
View article: Making Sense of “Apportionment” in Patent Damages
Making Sense of “Apportionment” in Patent Damages Open
Unreasonably large damages awards in patent litigation have been an important force in motivating the movement for patent reform. “Apportionment” has found support as a solution to problem damages awards. Under apportionment, the portion o…
View article: Analysis of the Molecular Mechanisms Governing FCγ Receptor Activation on the Surfaces of Macrophages by Advanced Optical Microscopy
Analysis of the Molecular Mechanisms Governing FCγ Receptor Activation on the Surfaces of Macrophages by Advanced Optical Microscopy Open
Therapeutic antibodies are achieving new levels of therapeutic success in treating cancers and immunological disorders by antibody engagement of Fc receptor-directed immune responses. Conversely, inhibiting autoantibody induced Fc receptor…
View article: Membrane bending occurs at all stages of clathrin-coat assembly and defines endocytic dynamics
Membrane bending occurs at all stages of clathrin-coat assembly and defines endocytic dynamics Open
View article: Membrane bending begins at any stage of clathrin-coat assembly and defines endocytic dynamics
Membrane bending begins at any stage of clathrin-coat assembly and defines endocytic dynamics Open
Summary Paragraph Clathrin-mediated endocytosis internalizes membrane from the cell surface by reshaping flat regions of membrane into spherical vesicles(1, 2). The relationship between membrane bending and clathrin coatomer assembly has b…
View article: TIRF imaging of Fc gamma receptor microclusters dynamics and signaling on macrophages during frustrated phagocytosis
TIRF imaging of Fc gamma receptor microclusters dynamics and signaling on macrophages during frustrated phagocytosis Open
View article: Behavioral Economics and U.S. Antitrust Policy
Behavioral Economics and U.S. Antitrust Policy Open