Michelle L. Frost
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View article: Utility of a simplified [18F] sodium fluoride PET imaging method to quantify bone metabolic flux for a wide range of clinical applications
Utility of a simplified [18F] sodium fluoride PET imaging method to quantify bone metabolic flux for a wide range of clinical applications Open
We review the rationale, methodology, and clinical utility of quantitative [ 18 F] sodium fluoride ([ 18 F]NaF) positron emission tomography-computed tomography (PET-CT) imaging to measure bone metabolic flux (K i , also known as bone plas…
View article: Input function and modeling for determining bone metabolic flux using [<sup>18</sup>F] sodium fluoride PET imaging: A step‐by‐step guide
Input function and modeling for determining bone metabolic flux using [<sup>18</sup>F] sodium fluoride PET imaging: A step‐by‐step guide Open
Studies of skeletal metabolism using measurements of bone metabolic flux (K i ) obtained with [ 18 F] sodium fluoride ([ 18 F]NaF) positron emission tomography (PET) scans have been used in clinical research for the last 30 years. The tech…
View article: Relationship Between Baseline Rectal Tumor Length and Magnetic Resonance Tumor Regression Grade Response to Chemoradiotherapy: A Subanalysis of the TRIGGER Feasibility Study
Relationship Between Baseline Rectal Tumor Length and Magnetic Resonance Tumor Regression Grade Response to Chemoradiotherapy: A Subanalysis of the TRIGGER Feasibility Study Open
View article: [18F] Sodium Fluoride PET Kinetic Parameters in Bone Imaging
[18F] Sodium Fluoride PET Kinetic Parameters in Bone Imaging Open
This report describes the significance of the kinetic parameters (k-values) obtained from the analysis of dynamic positron emission tomography (PET) scans using the Hawkins model describing the pharmacokinetics of sodium fluoride ([18F]NaF…
View article: A Short Dynamic Scan Method of Measuring Bone Metabolic Flux Using [18F]NaF PET
A Short Dynamic Scan Method of Measuring Bone Metabolic Flux Using [18F]NaF PET Open
[18F]NaF PET measurements of bone metabolic flux (Ki) are conventionally obtained with 60-min dynamic scans analysed using the Hawkins model. However, long scan times make this method expensive and uncomfortable for subjects. Therefore, we…
View article: The influence of CT and dual-energy X-ray absorptiometry (DXA) bone density on quantitative [18F] sodium fluoride PET
The influence of CT and dual-energy X-ray absorptiometry (DXA) bone density on quantitative [18F] sodium fluoride PET Open
The results demonstrate significant positive correlations between SUV and K i and vBMD measurements in the form of HU from CT or BMAD and areal BMD from DXA. These findings justify further exploration of the relationship …
View article: Evaluation of aortic <sup>18</sup>F-NaF tracer uptake using PET/CT as a predictor of aortic calcification in postmenopausal women: A longitudinal study
Evaluation of aortic <sup>18</sup>F-NaF tracer uptake using PET/CT as a predictor of aortic calcification in postmenopausal women: A longitudinal study Open
Introduction Aortic calcification as detected by computed tomography is associated with arterial stiffening and is an important predictor of cardiovascular morbidity and mortality. Uptake of 18 F-sodium fluoride ( 18 F-NaF) in the aortic w…
View article: Site specific measurements of bone formation using [18F] sodium fluoride PET/CT
Site specific measurements of bone formation using [18F] sodium fluoride PET/CT Open
Dynamic positron emission tomography (PET) imaging with fluorine-18 labelled sodium fluoride ([18F]NaF) allows the quantitative assessment of regional bone formation by measuring the plasma clearance of fluoride to bone at any s…
View article: A rectal cancer feasibility study with an embedded phase III trial design assessing magnetic resonance tumour regression grade (mrTRG) as a novel biomarker to stratify management by good and poor response to chemoradiotherapy (TRIGGER): study protocol for a randomised controlled trial
A rectal cancer feasibility study with an embedded phase III trial design assessing magnetic resonance tumour regression grade (mrTRG) as a novel biomarker to stratify management by good and poor response to chemoradiotherapy (TRIGGER): study protocol for a randomised controlled trial Open
View article: Bone Mineral Density and Body Composition are Associated with Circulating Angiogenic Factors in Post-menopausal Women
Bone Mineral Density and Body Composition are Associated with Circulating Angiogenic Factors in Post-menopausal Women Open
Lean mass (LM) and fat mass (FM) are closely related to bone mass (BM) in post-menopausal women, although their relative importance is unclear. Angiogenic factors which control angiogenesis may influence BM, LM and FM. The aim of the study…
View article: P5.15 EVALUATION OF AORTIC 18F-NAF TRACER UPTAKE DETECTED USING PET/CT IN PREDICTING AORTIC CALCIFICATION OVER A 4-YEAR FOLLOW-UP PERIOD
P5.15 EVALUATION OF AORTIC 18F-NAF TRACER UPTAKE DETECTED USING PET/CT IN PREDICTING AORTIC CALCIFICATION OVER A 4-YEAR FOLLOW-UP PERIOD Open
Background: Uptake of 18F-sodium fluoride (18F-NaF) in the aortic wall may reflect metabolically active areas of calcification, an important predictor of cardiovascular morbidity and mortality when detected by computed tomography (CT). The…