Michelle Higgins
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View article: A Bladder Matter: Redefining the Grading System for Pediatric Hemorrhagic Cystitis
A Bladder Matter: Redefining the Grading System for Pediatric Hemorrhagic Cystitis Open
Introduction: Pediatric hemorrhagic cystitis (HC) is a morbid, understudied condition ranging from microscopic hematuria to life-threatening hemorrhage. Existing grading systems, based on adult populations, fail to account for pediatric-sp…
View article: Alcohol consumption among patients diagnosed with genitourinary cancers
Alcohol consumption among patients diagnosed with genitourinary cancers Open
Objective To characterize alcohol consumption and binge‐drinking patterns among individuals with GU cancers (prostate, kidney, bladder and testicular) compared to a propensity‐matched cohort without cancer in a large, nationally diverse po…
View article: Physical Activity, Diet Quality, and Risk of Prostate Cancer Grade Reclassification on Active Surveillance: Results from a Prospective Cohort Study
Physical Activity, Diet Quality, and Risk of Prostate Cancer Grade Reclassification on Active Surveillance: Results from a Prospective Cohort Study Open
Background Higher diet quality may be associated with a reduced risk of prostate cancer (PCa) grade reclassification (GR) on active surveillance (AS). However, there remain limited and conflicting data regarding whether physical activity m…
View article: Prostate cancer active surveillance in solid organ transplant: a matched study and literature review
Prostate cancer active surveillance in solid organ transplant: a matched study and literature review Open
Objectives To evaluate outcomes of prostate cancer (PCa) active surveillance (AS) in patients with versus without solid organ transplant (SOT), as the safety of PCa AS in patients with SOT remains understudied. We also performed a literatu…
View article: Development and Validation of a Machine Learning Model That Uses Voice to Predict Aspiration Risk
Development and Validation of a Machine Learning Model That Uses Voice to Predict Aspiration Risk Open
Background Aspiration causes or aggravates a variety of respiratory diseases. Subjective bedside evaluations of aspiration are limited by poor inter-and intra-rater reliability, while gold standard diagnostic tests for aspiration, such as …
View article: 360 Using machine learning to analyze voice and detect aspiration
360 Using machine learning to analyze voice and detect aspiration Open
Objectives/Goals: Aspiration causes or aggravates lung diseases. While bedside swallow evaluations are not sensitive/specific, gold standard tests for aspiration are invasive, uncomfortable, expose patients to radiation, and are resource i…
View article: Detection of High-Grade Bladder Cancer in Urine Samples Using in Situ Hybridization of Long Non-Coding Rna Uca1
Detection of High-Grade Bladder Cancer in Urine Samples Using in Situ Hybridization of Long Non-Coding Rna Uca1 Open
View article: Non Breast-Milk-Fed Very Preterm Infants Are at Increased Risk of Iron Deficiency at 4–6-Months Corrected Age: A Retrospective Population-Based Cohort Study
Non Breast-Milk-Fed Very Preterm Infants Are at Increased Risk of Iron Deficiency at 4–6-Months Corrected Age: A Retrospective Population-Based Cohort Study Open
Iron supplementation is routinely recommended for breast-milk-fed preterm infants. However, the Canadian Pediatric Society recommends no additional iron supplementation for preterm infants fed primarily with iron-rich formula. Other pediat…
View article: 32 Risk Factors for Iron Deficiency in Formula-fed very Preterm Infants: A Population-based Study from Nova Scotia
32 Risk Factors for Iron Deficiency in Formula-fed very Preterm Infants: A Population-based Study from Nova Scotia Open
Background Iron prophylaxis is routinely recommended for preterm infants, as they are vulnerable to develop iron deficiency (ID). Recent work from our group has demonstrated that despite early iron prophylaxis, ID is common in very preterm…
View article: 31 Iron Deficiency in Formula-fed Very Preterm Infants: Do We Need to Revise Recommendations for Iron Supplementation?
31 Iron Deficiency in Formula-fed Very Preterm Infants: Do We Need to Revise Recommendations for Iron Supplementation? Open
Background Preterm infants are at risk for iron deficiency (ID). The Canadian Paediatric Society (CPS) recommends iron supplementation of 2 to 3mg/kg/day for breastfed (BF) preterm infants born <2 kg. Additional iron supplementation is …
View article: Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity
Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity Open
Individuals homozygous for the "Z" mutation in alpha-1 antitrypsin deficiency are known to be at increased risk for liver disease. It has also become clear that some degree of risk is similarly conferred by the heterozygous state. A lack o…
View article: Clinic friendly estimation of muscle composition: Preoperative linear segmentation shows overall survival correlated with muscle mass in patients with nonmetastatic renal cell carcinoma
Clinic friendly estimation of muscle composition: Preoperative linear segmentation shows overall survival correlated with muscle mass in patients with nonmetastatic renal cell carcinoma Open
Purpose Sarcopenia is associated with decreased survival and increased complications in patients with renal cell carcinoma. Readily identifying patients with low muscle composition that may experience worse outcomes or would benefit from p…
View article: Data regarding covariates significantly associated with sarcopenia and varying albumin statuses in patients with renal cell carcinoma
Data regarding covariates significantly associated with sarcopenia and varying albumin statuses in patients with renal cell carcinoma Open
View article: Modeling of Alpha-1 Antitrypsin Deficiency with Syngeneic Human iPSC-Hepatocytes Reveals Metabolic Dysregulation and Cellular Heterogeneity in PiMZ and PiZZ Hepatocytes
Modeling of Alpha-1 Antitrypsin Deficiency with Syngeneic Human iPSC-Hepatocytes Reveals Metabolic Dysregulation and Cellular Heterogeneity in PiMZ and PiZZ Hepatocytes Open
Individuals homozygous for the pathogenic “Z” mutation in alpha-1 antitrypsin deficiency (AATD) are known to be at increased risk for chronic liver disease. That some degree of risk is similarly conferred by the heterozygous state, estimat…
View article: Table of Contents (3 pgs)
Table of Contents (3 pgs) Open
View article: Sarcopenia and modified Glasgow Prognostic Score predict postsurgical outcomes in localized renal cell carcinoma
Sarcopenia and modified Glasgow Prognostic Score predict postsurgical outcomes in localized renal cell carcinoma Open
BACKGROUND Body composition and inflammation are gaining importance for prognostication in cancer. This study investigated the individual and combined utility of the preoperative skeletal muscle index (SMI) and the modified Glasgow Prognos…
View article: Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos Open
Body composition is associated with risk of disease progression and treatment complications in a variety of conditions. Therefore, quantification of skeletal muscle mass and adipose tissues on Computed Tomography (CT) and/or Magnetic Reson…
View article: Implementation and evaluation of eight virtual surgical electives for medical students during the COVID-19 pandemic
Implementation and evaluation of eight virtual surgical electives for medical students during the COVID-19 pandemic Open
View article: Who really knows the performance status: The physician or the patient?
Who really knows the performance status: The physician or the patient? Open
The Eastern Cooperative Oncology Group performance status is a crucial metric for evaluating patients with cancer because it informs the prognosis and treatment decisions. Discrepancies in patient and physician assessments of performance s…
View article: A Strategy for Undergraduate Medical Education in Urology During the COVID-19 Pandemic
A Strategy for Undergraduate Medical Education in Urology During the COVID-19 Pandemic Open
View article: A Highly Phenotyped Open Access Repository of Alpha-1 Antitrypsin Deficiency Pluripotent Stem Cells
A Highly Phenotyped Open Access Repository of Alpha-1 Antitrypsin Deficiency Pluripotent Stem Cells Open
Individuals with the genetic disorder alpha-1 antitrypsin deficiency (AATD) are at risk of developing lung and liver disease. Patient induced pluripotent stem cells (iPSCs) have been found to model features of AATD pathogenesis but only a …
View article: Multilineage transduction of resident lung cells in vivo by AAV2/8 for α1-antitrypsin gene therapy
Multilineage transduction of resident lung cells in vivo by AAV2/8 for α1-antitrypsin gene therapy Open