Michelle Hung
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View article: Precision off-the-shelf natural killer cell therapies for oncology with logic-gated gene circuits
Precision off-the-shelf natural killer cell therapies for oncology with logic-gated gene circuits Open
Acute myeloid leukemia (AML) is an aggressive disease with a poor prognosis (5-year survival rate of 30.5% in the United States). Designing cell therapies to target AML is challenging because no single tumor-associated antigen (TAA) is hig…
View article: 430 Smart sensor promoters drive state-specific gene circuits to convert immunosuppressive macrophages into an anti-tumor phenotype
430 Smart sensor promoters drive state-specific gene circuits to convert immunosuppressive macrophages into an anti-tumor phenotype Open
Background Immunosuppressive signaling from myeloid cells and macrophages in tumor microenvironments hampers the clinical efficacy of immunotherapies. Macrophages, however, are a highly plastic cell type that can be polarized to either a p…
View article: Source data for "Genetically encoding multiple functionalities into extracellular vesicles for the targeted delivery of biologics to T cells"
Source data for "Genetically encoding multiple functionalities into extracellular vesicles for the targeted delivery of biologics to T cells" Open
Source Data include all reported experimental data and plasmid maps for all plasmids generated in the associated publication, "Genetically encoding multiple functionalities into extracellular vesicles for the targeted delivery of biologics…
View article: Source data for "Genetically encoding multiple functionalities into extracellular vesicles for the targeted delivery of biologics to T cells"
Source data for "Genetically encoding multiple functionalities into extracellular vesicles for the targeted delivery of biologics to T cells" Open
Source Data include all reported experimental data and plasmid maps for all plasmids generated in the associated publication, "Genetically encoding multiple functionalities into extracellular vesicles for the targeted delivery of biologics…
View article: 221 SENTI-401, an allogeneic logic-gated and multi-armed CAR-NK cell therapy for the treatment of CEA-expressing solid tumors with enhanced selectivity and efficacy
221 SENTI-401, an allogeneic logic-gated and multi-armed CAR-NK cell therapy for the treatment of CEA-expressing solid tumors with enhanced selectivity and efficacy Open
Background Chimeric Antigen Receptor (CAR)-based cell-therapies have demonstrated clinical benefit in select blood cancers. Unfortunately, their success has yet to be translated to solid tumors. Poor antigen specificity and immune-suppress…
View article: 228 Multi-arming and regulator dial gene circuits tackle key challenges in solid tumors
228 Multi-arming and regulator dial gene circuits tackle key challenges in solid tumors Open
Background Chimeric antigen receptor (CAR) cell therapy for solid tumors is hampered by the immunosuppressive tumor microenvironment (TME), which can inhibit the function of endogenous and therapeutic immune cells, as well as a paucity of …
View article: A Systematic Evaluation of Factors Affecting Extracellular Vesicle Uptake by Breast Cancer Cells
A Systematic Evaluation of Factors Affecting Extracellular Vesicle Uptake by Breast Cancer Cells Open
Extracellular vesicles (EVs) are nanometer-scale particles that are secreted by cells and mediate intercellular communication by transferring biomolecules between cells. Harnessing this mechanism for therapeutic biomolecule delivery repres…
View article: Regulation of the IL-10-driven macrophage phenotype under incoherent stimuli
Regulation of the IL-10-driven macrophage phenotype under incoherent stimuli Open
Macrophages are ubiquitous innate immune cells that play a central role in health and disease by adopting distinct phenotypes, which are broadly divided into classical inflammatory responses and alternative responses that promote immune su…
View article: 496. Elucidating Design Rules Governing Extracellular Vesicle-Mediated Therapeutic Protein Delivery
496. Elucidating Design Rules Governing Extracellular Vesicle-Mediated Therapeutic Protein Delivery Open
Extracellular vesicles (EVs) are secreted biological nanoparticles that have great potential as therapeutic delivery vehicles - they are well-tolerated in vivo and naturally capable of transferring RNA and proteins between cells. Our abili…
View article: A platform for actively loading cargo RNA to elucidate limiting steps in EV‐mediated delivery
A platform for actively loading cargo RNA to elucidate limiting steps in EV‐mediated delivery Open
Extracellular vesicles (EVs) mediate intercellular communication through transfer of RNA and protein between cells. Thus, understanding how cargo molecules are loaded and delivered by EVs is of central importance for elucidating the biolog…