Michelle S. Yau
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View article: Genome-Wide Association Study of Radiographic Knee Osteoarthritis in North American Caucasians
Genome-Wide Association Study of Radiographic Knee Osteoarthritis in North American Caucasians Open
OBJECTIVE: A major barrier to genetic studies of osteoarthritis (OA) is the need to obtain large numbers of individuals with standardized radiographic evaluations for OA. To address this gap, we performed a genome-wide association study (G…
View article: Genetic Determinants of Radiographic Knee Osteoarthritis in African Americans
Genetic Determinants of Radiographic Knee Osteoarthritis in African Americans Open
OBJECTIVE: The etiology of knee osteoarthritis (OA), the most common form of arthritis, is complex and may differ by race or ethnicity. In recent years, genetic studies have identified many genetic variants associated with OA, but nearly a…
View article: Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain
Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain Open
Back pain is the #1 cause of years lived with disability worldwide, yet surprisingly little is known regarding the biology underlying this symptom. We conducted a genome-wide association study (GWAS) meta-analysis of chronic back pain (CBP…
View article: A Meta-Analysis of the Transferability of Bone Mineral Density Genetic Loci Associations From European to African Ancestry Populations
A Meta-Analysis of the Transferability of Bone Mineral Density Genetic Loci Associations From European to African Ancestry Populations Open
Genetic studies of bone mineral density (BMD) largely have been conducted in European populations. We therefore conducted a meta-analysis of six independent African ancestry cohorts to determine whether previously reported BMD loci identif…
View article: Genome-wide meta-analysis identified novel variant associated with hallux valgus in Caucasians
Genome-wide meta-analysis identified novel variant associated with hallux valgus in Caucasians Open
Background: Hallux valgus, one of the most common structural foot deformities, is highly heritable. However, previous efforts to elucidate the genetic underpinnings of hallux valgus through a genome-wide association study (GWAS) conducted …
View article: Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and Its Risk Factors: Evidence From a <scp>Genome‐Wide</scp> Association <scp>Meta‐Analysis</scp> Followed by Mendelian Randomization
Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and Its Risk Factors: Evidence From a <span>Genome‐Wide</span> Association <span>Meta‐Analysis</span> Followed by Mendelian Randomization Open
Objective In this study, we aimed to establish the causal effects of lowering sclerostin, target of the antiosteoporosis drug romosozumab, on atherosclerosis and its risk factors. Methods A genome‐wide association study meta‐analysis was p…
View article: Do associations with hand OA vary by knee osteoarthritis phenotype? Cross-sectional data from the Multicenter Osteoarthritis Study
Do associations with hand OA vary by knee osteoarthritis phenotype? Cross-sectional data from the Multicenter Osteoarthritis Study Open
Age-adjusted associations between hand and knee OA were modest and were largely similar across knee OA phenotypes.
View article: Lowering of circulating sclerostin may increase risk of atherosclerosis and its risk factors: evidence from a genome-wide association meta-analysis followed by Mendelian randomization
Lowering of circulating sclerostin may increase risk of atherosclerosis and its risk factors: evidence from a genome-wide association meta-analysis followed by Mendelian randomization Open
Sclerostin inhibition is a new therapeutic approach for increasing bone mineral density (BMD) but its cardiovascular safety is unclear. We conducted a genome-wide association study (GWAS) meta-analysis of circulating sclerostin in 33,961 E…
View article: Toward Precision Medicine—Is Genetic Risk Prediction Ready for Prime Time in Osteoarthritis?
Toward Precision Medicine—Is Genetic Risk Prediction Ready for Prime Time in Osteoarthritis? Open
Disclosure Form Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author f…
View article: A Meta-Analysis of the Transferability of Bone Mineral Density Genetic Loci Associations From European to African Ancestry Populations
A Meta-Analysis of the Transferability of Bone Mineral Density Genetic Loci Associations From European to African Ancestry Populations Open
Genetic studies of bone mineral density (BMD) largely have been conducted in European populations. We therefore conducted a meta-analysis of six independent African ancestry cohorts to determine whether previously reported BMD loci identif…
View article: Association between disease progression and depression onset in persons with radiographic knee osteoarthritis
Association between disease progression and depression onset in persons with radiographic knee osteoarthritis Open
Objectives Osteoarthritis (OA) disease progression may lead to deteriorating psychosocial function, but it is unclear what aspects of disease severity are related to the onset of depression. This study assessed which components of OA disea…
View article: Genome‐wide meta‐analysis identified novel variant associated with hallux valgus in Caucasians
Genome‐wide meta‐analysis identified novel variant associated with hallux valgus in Caucasians Open
Background Hallux valgus, one of the most common structural foot deformities, is highly heritable. However, previous efforts to elucidate the genetic underpinnings of hallux valgus through a genome‐wide association study (GWAS) conducted i…
View article: Depression Subtypes in Individuals With or at Risk for Symptomatic Knee Osteoarthritis
Depression Subtypes in Individuals With or at Risk for Symptomatic Knee Osteoarthritis Open
Objective The present study was undertaken to identify depression subtypes in individuals with or at risk for symptomatic knee osteoarthritis (OA) and to evaluate differences in pain and disability trajectories between groups. Methods Part…
View article: A genome-wide association study identifies that the GDF5 and COL27A1 genes are associated with knee pain in UK Biobank (N = 171, 516)
A genome-wide association study identifies that the GDF5 and COL27A1 genes are associated with knee pain in UK Biobank (N = 171, 516) Open
SUMMARY Objective Knee pain is one of the most common musculoskeletal complaints that brings people to medical attention. We sought to identify the genetic variants associated with knee pain in 171,516 subjects from the UK Biobank cohort a…
View article: Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain
Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain Open
Back pain is the #1 cause of years lived with disability worldwide, yet surprisingly little is known regarding the biology underlying this symptom. We conducted a genome-wide association study (GWAS) meta-analysis of chronic back pain (CBP…
View article: Genome-wide Meta-analysis of 158,000 Individuals of European Ancestry Identifies Three Loci Associated with Chronic Back Pain
Genome-wide Meta-analysis of 158,000 Individuals of European Ancestry Identifies Three Loci Associated with Chronic Back Pain Open
OBJECTIVES To conduct a genome-wide association study (GWAS) meta-analysis of chronic back pain (CBP). METHODS Adults of European ancestry were included from 16 cohorts in Europe and North America. CBP cases were defined as those reporting…