Michelle M. Felicella
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View article: A framework for using DNA methylation-based modelling for the clinical management of cranial meningioma
A framework for using DNA methylation-based modelling for the clinical management of cranial meningioma Open
Background DNA methylation profiling can be used to robustly predict postsurgical outcomes and response to radiotherapy (RT) for meningioma patients. To allow for seamless integration of these complementary models into clinical practice, a…
View article: Malignant peripheral nerve sheath tumor presenting in the cauda equina: diagnostic and biological pearls. Illustrative case
Malignant peripheral nerve sheath tumor presenting in the cauda equina: diagnostic and biological pearls. Illustrative case Open
BACKGROUND Malignant peripheral nerve sheath tumors (MPNSTs) are rare and highly malignant tumors of neural crest origin. No matter their anatomical location, they are difficult to treat and carry a poor prognosis. OBSERVATIONS This report…
View article: Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma
Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma Open
Treatment of the tumor and dural margin with surgery and sometimes radiation are cornerstones of therapy for meningioma. Molecular classifications have provided insights into the biology of disease; however, response to treatment remains h…
View article: Eosinophilic myenteric ganglionitis: A case in a 14‐year‐old‐male
Eosinophilic myenteric ganglionitis: A case in a 14‐year‐old‐male Open
Chronic intestinal pseudo‐obstruction (CIPO) is a rare, severe, and often debilitating condition that can result in significant morbidity and mortality amongst the pediatric population. Eosinophilic myenteric ganglionitis (EMG) is a rare i…
View article: Improved immunostaining of nanostructures and cells in human brain specimens through expansion-mediated protein decrowding
Improved immunostaining of nanostructures and cells in human brain specimens through expansion-mediated protein decrowding Open
Proteins are densely packed in cells and tissues, where they form complex nanostructures. Expansion microscopy (ExM) variants have been used to separate proteins from each other in preserved biospecimens, improving antibody access to epito…
View article: Awake resection of recurrent astroblastoma with intraoperative 5-ALA–induced fluorescence: illustrative case
Awake resection of recurrent astroblastoma with intraoperative 5-ALA–induced fluorescence: illustrative case Open
BACKGROUND Astroblastoma is a rare neoplasm characterized as a circumscribed glial neoplasm most often arising in the frontoparietal cerebral hemispheres in older children. OBSERVATIONS We report an intriguing case of an astroblastoma recu…
View article: Endocisternal interfaces for minimally invasive neural stimulation and recording of the brain and spinal cord
Endocisternal interfaces for minimally invasive neural stimulation and recording of the brain and spinal cord Open
Minimally invasive neural interfaces can be used to diagnose, manage, and treat many disorders with substantially reduced risks of surgical complications. Endovascular neural interfaces implanted in the veins or arteries is one approach, b…
View article: System-based integrated metabolomics and microRNA analysis identifies potential molecular alterations in human X-linked cerebral adrenoleukodystrophy brain
System-based integrated metabolomics and microRNA analysis identifies potential molecular alterations in human X-linked cerebral adrenoleukodystrophy brain Open
X-linked adrenoleukodystrophy is a severe demyelinating neurodegenerative disease mainly affecting males. The severe cerebral adrenoleukodystrophy (cALD) phenotype has a poor prognosis and underlying mechanism of onset and progression of n…
View article: Circulating exosomes from Alzheimer’s disease suppress VE-cadherin expression and induce barrier dysfunction in recipient brain microvascular endothelial cell
Circulating exosomes from Alzheimer’s disease suppress VE-cadherin expression and induce barrier dysfunction in recipient brain microvascular endothelial cell Open
Background Blood-brain barrier (BBB) breakdown is a component of the progression and pathology of Alzheimer’s disease (AD). BBB dysfunction is primarily caused by reduced or disorganized tight junction or adherens junction proteins of brai…
View article: A Fatal Fungal Infection: <i>Cryptococcus gattii</i> (VGI) Meningitis in Texas
A Fatal Fungal Infection: <i>Cryptococcus gattii</i> (VGI) Meningitis in Texas Open
Cryptococcus gattii is an underrecognized cause of meningitis, especially in nonendemic regions. This report details C gattii disease progression from admission to autopsy in an otherwise healthy 40-year-old male in Texas. It brings awaren…
View article: Information theory approaches to improve glioma diagnostic workflows in surgical neuropathology
Information theory approaches to improve glioma diagnostic workflows in surgical neuropathology Open
Aims Resource‐strained healthcare ecosystems often struggle with the adoption of the World Health Organization (WHO) recommendations for the classification of central nervous system (CNS) tumors. The generation of robust clinical diagnosti…
View article: Wireless endovascular nerve stimulation with a millimeter-sized magnetoelectric implant
Wireless endovascular nerve stimulation with a millimeter-sized magnetoelectric implant Open
Implanted bioelectronic devices have the potential to treat disorders that are resistant to traditional pharmacological therapies; however, reaching many therapeutic nerve targets requires invasive surgeries and implantation of centimeter-…
View article: P13.15 DNA methylation abnormalities in non-promoter regulatory regions are associated with invasive behavior in pituitary tumors
P13.15 DNA methylation abnormalities in non-promoter regulatory regions are associated with invasive behavior in pituitary tumors Open
BACKGROUND Despite histologically benign, pituitary tumors (PT) may invade important adjacent neurovascular structures which can incur in significant comorbidities preventing a complete surgical resection and contributing to resistance to …
View article: OR24-5 Aberrant DNA Methylation in Regulatory Genomic Elements Are Associated with Invasive Behavior of Pituitary Macroadenomas: An Integrative Analysis of Epigenome-Wide Studies
OR24-5 Aberrant DNA Methylation in Regulatory Genomic Elements Are Associated with Invasive Behavior of Pituitary Macroadenomas: An Integrative Analysis of Epigenome-Wide Studies Open
A significant proportion of pituitary tumors (PT) invade adjacent structures. Few putative somatic mutations or copy number alterations have been associated with PT invasiveness. DNA methylation abnormalities in regulatory regions are know…
View article: GENE-07. GENOMIC ENHANCER METHYLATION IS ASSOCIATED WITH BIOLOGICAL AND CLINICAL FEATURES IN PITUITARY TUMORS
GENE-07. GENOMIC ENHANCER METHYLATION IS ASSOCIATED WITH BIOLOGICAL AND CLINICAL FEATURES IN PITUITARY TUMORS Open
The importance of enhancers has been recently highlighted in a pan-can transcriptomic analysis that revealed causal interaction between active enhancers and actionable genes as well as their prognostic value. DNA methylation is associated …
View article: Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma
Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma Open
To understand how genomic heterogeneity of glioblastoma (GBM) contributes to the poor response to therapy, which is characteristic of this disease, we performed DNA and RNA sequencing on GBM tumor samples and the neurospheres and orthotopi…
View article: Metformin‐induced mitochondrial function and <scp>ABCD</scp>2 up‐regulation in X‐linked adrenoleukodystrophy involves <scp>AMP</scp>‐activated protein kinase
Metformin‐induced mitochondrial function and <span>ABCD</span>2 up‐regulation in X‐linked adrenoleukodystrophy involves <span>AMP</span>‐activated protein kinase Open
X‐linked adrenoleukodystrophy (X‐ ALD ) is a progressive neurometabolic disease caused by mutations/deletions in the Abcd1 gene. Similar mutations/deletions in the Abcd1 gene often result in diagonally opposing phenotypes of mild adrenomye…