Michelle Melanson
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View article: The <i>9p21.3</i> Coronary Artery Disease Risk Locus Modulates Vascular Cell-State Transitions via Enhancer-Driven Regulation of <i>MTAP</i>
The <i>9p21.3</i> Coronary Artery Disease Risk Locus Modulates Vascular Cell-State Transitions via Enhancer-Driven Regulation of <i>MTAP</i> Open
Summary The 9p21.3 locus is the strongest genetic association with coronary artery disease (CAD), yet its causal mechanisms remain unresolved. We map the regulatory architecture of 9p21.3 in disease-relevant vascular cells, identifying 12 …
View article: A Fast-Binding, Functionally Reversible, COX-2 Radiotracer for CNS PET Imaging
A Fast-Binding, Functionally Reversible, COX-2 Radiotracer for CNS PET Imaging Open
Cyclooxygenase-2 (COX-2) is an enzyme that plays a pivotal role in peripheral inflammation and pain via the prostaglandin pathway. In the central nervous system (CNS), COX-2 is implicated in neurodegenerative and psychiatric disorders as a…
View article: Optimizing the Cell Painting assay for image-based profiling
Optimizing the Cell Painting assay for image-based profiling Open
In image-based profiling, software extracts thousands of morphological features of cells from multi-channel fluorescence microscopy images, yielding single-cell profiles that can be used for basic research and drug discovery. Powerful appl…
View article: Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations
Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations Open
Identifying genetic and chemical perturbations with similar impacts on cell morphology can reveal compounds’ mechanisms of action or novel regulators of genetic pathways. Research on methods for identifying such similarities has lagged due…
View article: A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic
A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic Open
Summary Drug repurposing is the only method capable of delivering treatments on the shortened time-scale required for patients afflicted with lung disease arising from SARS-CoV-2 infection. Mucin-1 (MUC1), a membrane-bound molecule express…