Mandy Kwong
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View article: Effectorless Fc-fusion improves FLT3L drug-like properties for cancer immunotherapy combinations
Effectorless Fc-fusion improves FLT3L drug-like properties for cancer immunotherapy combinations Open
This work was performed at, and funded by Genentech Inc. South San Francisco, CA 94080, USA.
View article: Engineered IL-18 variants with half-life extension and improved stability for cancer immunotherapy
Engineered IL-18 variants with half-life extension and improved stability for cancer immunotherapy Open
Background The pro-inflammatory cytokine, interleukin-18 (IL-18), plays an instrumental role in bolstering anti-tumor immunity. However, the therapeutic application of IL-18 has been limited due to its susceptibility to neutralization by I…
View article: Leveraging neonatal Fc receptor (FcRn) to enhance antibody transport across the blood brain barrier
Leveraging neonatal Fc receptor (FcRn) to enhance antibody transport across the blood brain barrier Open
The blood-brain barrier (BBB) restricts efficient penetration of systemically delivered therapeutic antibodies into the brain, limiting the development of this class of drugs to treat neurodegenerative diseases. Here we demonstrate that th…
View article: A Bispecific Modeling Framework Enables the Prediction of Efficacy, Toxicity, and Optimal Molecular Design of Bispecific Antibodies Targeting MerTK
A Bispecific Modeling Framework Enables the Prediction of Efficacy, Toxicity, and Optimal Molecular Design of Bispecific Antibodies Targeting MerTK Open
Inhibiting MerTK on macrophages is a promising therapeutic strategy for augmenting anti-tumor immunity. However, blocking MerTK on retinal pigment epithelial cells (RPEs) results in retinal toxicity. Bispecific antibodies (bsAbs) containin…
View article: Identification of Tropical Plant Extracts That Extend Yeast Chronological Life Span
Identification of Tropical Plant Extracts That Extend Yeast Chronological Life Span Open
Certain plant extracts (PEs) contain bioactive compounds that have antioxidant and lifespan-extending activities on organisms. These PEs play different roles in cellular processes, such as enhancing stress resistance and modulating longevi…
View article: Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model
Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model Open
TREM2 is an Alzheimer's disease (AD) risk gene expressed in microglia. To study the role of Trem2 in a mouse model of β-amyloidosis, we compared PS2APP transgenic mice versus PS2APP mice lacking Trem2 (PS2APP;Trem2 ko ) at ages ranging fro…
View article: Metabolic Response to NAD Depletion across Cell Lines Is Highly Variable
Metabolic Response to NAD Depletion across Cell Lines Is Highly Variable Open
Nicotinamide adenine dinucleotide (NAD) is a cofactor involved in a wide range of cellular metabolic processes and is a key metabolite required for tumor growth. NAMPT, nicotinamide phosphoribosyltransferase, which converts nicotinamide (N…