Michelle So
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View article: Dialysis for Parathyroid Tumor Crises to Combat Ventricular Arrhythmia Risk: A Report of 2 Cases
Dialysis for Parathyroid Tumor Crises to Combat Ventricular Arrhythmia Risk: A Report of 2 Cases Open
A parathyroid crisis is a rare endocrine emergency characterized by life-threatening hypercalcemia, often due to delayed presentations with severe primary hyperparathyroidism. Prompt identification and management are crucial to mitigate po…
View article: β-Cell Function Derived From Routine Clinical Measures Reports and Predicts Treatment Response to Immunotherapy in Recent-Onset Type 1 Diabetes
β-Cell Function Derived From Routine Clinical Measures Reports and Predicts Treatment Response to Immunotherapy in Recent-Onset Type 1 Diabetes Open
OBJECTIVE Baricitinib preserves β-cell function in people with recently diagnosed type 1 diabetes. We aimed to determine whether simple routine clinical measures could be used to assess β-cell preservation and predict treatment response. R…
View article: Beta cell function derived from routine clinical measures reports and predicts treatment response to immunotherapy in recent-onset type 1 diabetes.
Beta cell function derived from routine clinical measures reports and predicts treatment response to immunotherapy in recent-onset type 1 diabetes. Open
ObjectiveBaricitinib preserves beta cell function in people with recently-diagnosed type 1 diabetes. We aimed to determine if simple routine clinical measures could be used to assess beta cell preservation and predict treatment response.Re…
View article: Beta cell function derived from routine clinical measures reports and predicts treatment response to immunotherapy in recent-onset type 1 diabetes.
Beta cell function derived from routine clinical measures reports and predicts treatment response to immunotherapy in recent-onset type 1 diabetes. Open
ObjectiveBaricitinib preserves beta cell function in people with recently-diagnosed type 1 diabetes. We aimed to determine if simple routine clinical measures could be used to assess beta cell preservation and predict treatment response.Re…
View article: Attenuated IL-2 muteins leverage the TCR signal to enhance regulatory T cell homeostasis and response in vivo
Attenuated IL-2 muteins leverage the TCR signal to enhance regulatory T cell homeostasis and response in vivo Open
Interleukin-2 (IL-2), along with T-cell receptor (TCR) signaling, are required to control regulatory T cell (Treg) homeostasis and function in vivo . Due to the heightened sensitivity to IL-2, Tregs retain the ability to respond to low-dos…
View article: Hydroxychloroquine in Stage 1 Type 1 Diabetes
Hydroxychloroquine in Stage 1 Type 1 Diabetes Open
OBJECTIVE Innate immune responses may be involved in the earliest phases of type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS To test whether blocking innate immaune cells modulated progression of the disease, we randomly assigned 273 ind…
View article: Investigating the efficacy of baricitinib in new onset type 1 diabetes mellitus (BANDIT)—study protocol for a phase 2, randomized, placebo controlled trial
Investigating the efficacy of baricitinib in new onset type 1 diabetes mellitus (BANDIT)—study protocol for a phase 2, randomized, placebo controlled trial Open
Background Type 1 diabetes (T1D) places an extraordinary burden on individuals and their families, as well as on the healthcare system. Despite recent advances in glucose sensors and insulin pump technology, only a minority of patients mee…
View article: Characterising the age-dependent effects of risk factors on type 1 diabetes progression
Characterising the age-dependent effects of risk factors on type 1 diabetes progression Open
Analysing the age-varying effect of disease predictors improves understanding and prediction of type 1 diabetes disease progression, and should be leveraged to refine prediction models and guide mechanistic studies.
View article: Advances in Type 1 Diabetes Prediction Using Islet Autoantibodies: Beyond a Simple Count
Advances in Type 1 Diabetes Prediction Using Islet Autoantibodies: Beyond a Simple Count Open
Islet autoantibodies are key markers for the diagnosis of type 1 diabetes. Since their discovery, they have also been recognized for their potential to identify at-risk individuals prior to symptoms. To date, risk prediction using autoanti…
View article: Combination product of dermal matrix, human mesenchymal stem cells, and timolol promotes diabetic wound healing in mice
Combination product of dermal matrix, human mesenchymal stem cells, and timolol promotes diabetic wound healing in mice Open
Diabetic foot ulcers are a major health care concern with limited effective therapies. Mesenchymal stem cell (MSC)-based therapies are promising treatment options due to their beneficial effects of immunomodulation, angiogenesis, and other…
View article: Response to Comment on So et al. Autoantibody Reversion: Changing Risk Categories in Multiple-Autoantibody–Positive Individuals. Diabetes Care 2020;43:913–917
Response to Comment on So et al. Autoantibody Reversion: Changing Risk Categories in Multiple-Autoantibody–Positive Individuals. Diabetes Care 2020;43:913–917 Open
We would like to thank Alhamar et al. (1) for their perspective on our article, which included questions regarding the utility of standard autoantibody measures in characterizing preclinical type 1 diabetes and recruitment of prevention tr…
View article: Autoantibody Reversion: Changing Risk Categories in Multiple-Autoantibody–Positive Individuals
Autoantibody Reversion: Changing Risk Categories in Multiple-Autoantibody–Positive Individuals Open
OBJECTIVE Most individuals with two or more islet autoantibodies progress to clinical type 1 diabetes. However, in some individuals, autoantibodies are subsequently lost. Here, our objectives were to determine the frequency of autoantibody…
View article: Topical Fluoxetine as a Novel Therapeutic That Improves Wound Healing in Diabetic Mice
Topical Fluoxetine as a Novel Therapeutic That Improves Wound Healing in Diabetic Mice Open
Diabetic foot ulcers represent a significant source of morbidity in the U.S., with rapidly escalating costs to the health care system. Multiple pathophysiological disturbances converge to result in delayed epithelialization and persistent …
View article: Proinsulin C-peptide is an autoantigen in people with type 1 diabetes
Proinsulin C-peptide is an autoantigen in people with type 1 diabetes Open
Significance Type 1 diabetes (T1D) is an incurable autoimmune disease caused by T cell-mediated destruction of insulin-producing beta cells. The beta-cell antigens recognized by human CD4 + T cells in T1D are poorly defined. Here, we show …
View article: Shuffling peptides to create T‐cell epitopes: does the immune system play cards?
Shuffling peptides to create T‐cell epitopes: does the immune system play cards? Open
For a long time, immunologists have believed that classical CD 4 + and CD 8 + T cells recognize peptides (referred to as epitopes), derived from protein antigens presented by MHC / HLA class I or II . Over the past 10–15 years, it has beco…