Michelle Yee Mun Teo
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View article: Advancements in antibody-drug conjugates as cancer therapeutics
Advancements in antibody-drug conjugates as cancer therapeutics Open
Antibody-drug conjugates (ADCs) represent a promising approach in targeted cancer therapy, combining the targeted precision of antibodies with the potency of cytotoxic payloads to selectively target tumour cell whilst minimising off-target…
View article: Recent Developments in Luteolin-Loaded Nanoformulations for Enhanced Anti-Carcinogenic Activities: Insights from In Vitro and In Vivo Studies
Recent Developments in Luteolin-Loaded Nanoformulations for Enhanced Anti-Carcinogenic Activities: Insights from In Vitro and In Vivo Studies Open
With approximately 18 million people affected by cancer in 2020 globally, scientists are exploring innovative approaches to develop effective treatments for various types of cancer. Traditional chemotherapy drugs, although effective agains…
View article: Development and characterization of anti-G12V mutated K-Ras monoclonal antibodies using hybridoma technology
Development and characterization of anti-G12V mutated K-Ras monoclonal antibodies using hybridoma technology Open
Background. Kirsten rat sarcoma oncogene, KRAS, is a gene that encodes for K-Ras protein, a membrane-anchored protein which is involved in intracellular signal transduction. Cells harbouring KRAS mutations have been reported to progress to…
View article: Aptamer Development for Cancer Diagnostic
Aptamer Development for Cancer Diagnostic Open
Early diagnosis improves the prognosis for cancer patients by allowing early intervention to slow or prevent cancer development and lethality. Aptamers are short single-stranded oligonucleotides that have a length of about 25–80 bases. The…
View article: Biophysical Evaluation of Water-Soluble Curcumin Encapsulated in β-Cyclodextrins on Colorectal Cancer Cells
Biophysical Evaluation of Water-Soluble Curcumin Encapsulated in β-Cyclodextrins on Colorectal Cancer Cells Open
Curcumin (CUR), a curcuminoid originating from turmeric root, possesses diverse pharmacological applications, including potent anticancer properties. However, the use of this efficacious agent in cancer therapy has been limited due to low …
View article: Endolysins against Streptococci as an antibiotic alternative
Endolysins against Streptococci as an antibiotic alternative Open
Multi-drug resistance has called for a race to uncover alternatives to existing antibiotics. Phage therapy is one of the explored alternatives, including the use of endolysins, which are phage-encoded peptidoglycan hydrolases responsible f…
View article: Development of fermented milk using food-grade recombinant Lactococcus lactis NZ3900
Development of fermented milk using food-grade recombinant Lactococcus lactis NZ3900 Open
Fermented milk has been associated with the improvement of human health for decades. Food-grade Lactococcus lactis NZ3900 is a potential host for producing and delivering various biologics, including oral vaccines, hence it could enhance t…
View article: Recombinant cell penetrating peptides and intrabodies targeting membrane-bound mutated KRAS antigens
Recombinant cell penetrating peptides and intrabodies targeting membrane-bound mutated KRAS antigens Open
One of the drivers for early carcinogenesis involves specific somatic point substitution mutations in the KRAS gene which damages its ability to conduct signal transduction. Although antibodies can be used for the targeting of KRAS antigen…
View article: Development of a single-chain fragment variable fused-mutant HALT-1 recombinant immunotoxin against G12V mutated <i>KRAS c</i>olorectal cancer cells
Development of a single-chain fragment variable fused-mutant HALT-1 recombinant immunotoxin against G12V mutated <i>KRAS c</i>olorectal cancer cells Open
Background KRAS oncogenes harboring codon G12 and G13 substitutions are considered gatekeeper mutations which drive oncogenesis in many cancers. To date, there are still no target-specific vaccines or drugs available against this genotype,…
View article: Cytotoxic and apoptosis-inducing effects of wildtype and mutated <i>Hydra</i> actinoporin-like toxin 1 (HALT-1) on various cancer cell lines
Cytotoxic and apoptosis-inducing effects of wildtype and mutated <i>Hydra</i> actinoporin-like toxin 1 (HALT-1) on various cancer cell lines Open
Background Hydra actinoporin like toxin -1 (HALT-1), is a small 18.5 kDa pore forming toxin derived from Hydra magnipapillata which has been shown to elicit strong haemolytic and cytolytic activity when in contact with cell membranes. Due …
View article: In silico-guided sequence modifications of K-ras epitopes improve immunological outcome against G12V and G13D mutant <i>KRAS</i> antigens
In silico-guided sequence modifications of K-ras epitopes improve immunological outcome against G12V and G13D mutant <i>KRAS</i> antigens Open
Background Somatic point substitution mutations in the KRAS proto-oncogene primarily affect codons 12/13 where glycine is converted into other amino acids, and are highly prevalent in pancreatic, colorectal, and non-small cell lung cancers…