Michelle Thom
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View article: Transcription factor expression for identifying B cell subsets in cattle by flow cytometry
Transcription factor expression for identifying B cell subsets in cattle by flow cytometry Open
With their capacity for antibody production, B cells underpin many protective immune responses, but they can also contribute to immunopathology and autoimmunity. Studying their differentiation following antigen encounter is therefore a key…
View article: Protective Efficacy of BCG Vaccination in Calves Vaccinated at Different Ages
Protective Efficacy of BCG Vaccination in Calves Vaccinated at Different Ages Open
Mycobacterium bovis, the causative agent of bovine tuberculosis (bTB), is a globally prevalent pathogen with significant animal welfare, economic and public health impacts. In the UK, the control of bTB relies on detection via tuberculin s…
View article: Towards Reverse Vaccinology for Bovine TB: High Throughput Expression of Full Length Recombinant Mycobacterium bovis Proteins
Towards Reverse Vaccinology for Bovine TB: High Throughput Expression of Full Length Recombinant Mycobacterium bovis Proteins Open
Bovine tuberculosis caused by Mycobacterium bovis , is a significant global pathogen causing economic loss in livestock and zoonotic TB in man. Several vaccine approaches are in development including reverse vaccinology which uses an unbia…
View article: Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion
Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion Open
RV521 is an orally bioavailable inhibitor of respiratory syncytial virus (RSV) fusion that was identified after a lead optimization process based upon hits that originated from a physical property directed hit profiling exercise at Reviral…
View article: Recombinant SARS-CoV-2 spike proteins for sero-surveillance and epitope mapping
Recombinant SARS-CoV-2 spike proteins for sero-surveillance and epitope mapping Open
The newly emergent SARS-CoV-2 coronavirus is closely related to SARS-CoV which emerged in 2002. Studies on coronaviruses in general, and SARS in particular, have identified the virus spike protein (S) as being central to virus tropism, to …
View article: Adjuvants and the vaccine response to the DS-Cav1-stabilized fusion glycoprotein of respiratory syncytial virus
Adjuvants and the vaccine response to the DS-Cav1-stabilized fusion glycoprotein of respiratory syncytial virus Open
Appropriate adjuvant selection may be essential to optimize the potency and to tailor the immune response of subunit vaccines. To induce protective responses against respiratory syncytial virus (RSV)-a highly prevalent childhood pathogen w…
View article: Protection of calves by a prefusion-stabilized bovine RSV F vaccine
Protection of calves by a prefusion-stabilized bovine RSV F vaccine Open
Bovine respiratory syncytial virus, a major cause of respiratory disease in calves, is closely related to human RSV, a leading cause of respiratory disease in infants. Recently, promising human RSV-vaccine candidates have been engineered t…
View article: Influence of Respiratory Syncytial Virus F Glycoprotein Conformation on Induction of Protective Immune Responses
Influence of Respiratory Syncytial Virus F Glycoprotein Conformation on Induction of Protective Immune Responses Open
Human respiratory syncytial virus (hRSV) vaccine development has received new impetus from structure-based studies of its main protective antigen, the fusion (F) glycoprotein. Three soluble forms of F have been described: monomeric, trimer…