Michelle Khai Khun Yap
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View article: Targeting cobra venom cytotoxin: a linear 40-mer ssDNA aptamer-based antivenom confers neutralisation potentials against cobra venom-induced cytotoxicity
Targeting cobra venom cytotoxin: a linear 40-mer ssDNA aptamer-based antivenom confers neutralisation potentials against cobra venom-induced cytotoxicity Open
Cytotoxin (CTX) is one of the major cobra venom components that contributes to dermonecrosis due to its cytotoxicity. However, current antibody-based antivenoms exert limited neutralisation effects against CTX-induced dermonecrosis. This s…
View article: A spatiotemporal study of a recreational freshwater lake: ultraperformance liquid chromatography–tandem mass spectrometry profiling of cyanotoxins and the dermal toxicity assessment
A spatiotemporal study of a recreational freshwater lake: ultraperformance liquid chromatography–tandem mass spectrometry profiling of cyanotoxins and the dermal toxicity assessment Open
Cyanotoxins are toxic secondary metabolites produced by cyanobacteria with significant health risks to aquatic ecosystems and humans. In this study, spatiotemporal profiling of cyanotoxins from a recreational freshwater lake were determine…
View article: Annexin A2 is a potential membrane protein target of cobra venom cytotoxin
Annexin A2 is a potential membrane protein target of cobra venom cytotoxin Open
Cytotoxin (CTX), a three-finger toxin in cobra venoms, is known to cause cytotoxicity, though inconclusive mechanisms are reported. This study discovered the potential cell membrane protein target of CTX using crosslinking differential mas…
View article: The neutralisation and inhibitory effects of new tRNA-mimetic aptamer against cytotoxin-induced cytotoxicity in human skin keratinocytes
The neutralisation and inhibitory effects of new tRNA-mimetic aptamer against cytotoxin-induced cytotoxicity in human skin keratinocytes Open
View article: Deciphering toxico-proteomics of Asiatic medically significant venomous snake species: A systematic review and interactive data dashboard
Deciphering toxico-proteomics of Asiatic medically significant venomous snake species: A systematic review and interactive data dashboard Open
Snakebite envenomation (SBE) is a neglected tropical disease (NTD) with an approximate 1.8 million cases annually. The tremendous figure is concerning, and the currently available treatment for snakebite envenomation is antivenom. However,…
View article: Guarding our water together: the silent threats and sustainable solutions of cyanotoxins monitoring in freshwater
Guarding our water together: the silent threats and sustainable solutions of cyanotoxins monitoring in freshwater Open
Cyanotoxins are the hidden dangers of freshwater lakes produced by cyanobacteria in warm and nutrient-rich environments, which are becoming more prevalent due to climate changes. The sophisticated monitoring methods of cyanotoxins, such as…
View article: Editorial: Experimental and computational aspects of bioactive proteins from animal venoms: an insight into pharmacological properties and drug discovery
Editorial: Experimental and computational aspects of bioactive proteins from animal venoms: an insight into pharmacological properties and drug discovery Open
Editorial: Experimental and computational aspects of bioactive proteins from animal venoms: an insight into pharmacological properties and drug discovery
View article: Unravelling the Gastroprotective Potential of Kefir: Exploring Antioxidant Effects in Preventing Gastric Ulcers
Unravelling the Gastroprotective Potential of Kefir: Exploring Antioxidant Effects in Preventing Gastric Ulcers Open
The present study was conducted to evaluate the protective effect of milk kefir against NSAID-induced gastric ulcers. Male Swiss mice were divided into three groups: control (Vehicle; UHT milk at a dose of 0.3 mL/100 g), proton pump inhibi…
View article: Moringa oleifera protein isolates: In silico analysis of bioactivity, allergenicity, and toxicity, and application in plant-based burgers
Moringa oleifera protein isolates: In silico analysis of bioactivity, allergenicity, and toxicity, and application in plant-based burgers Open
Moringa oleifera seeds are excellent sources of protein. In this study, the potential bioactivity, allergenicity, and toxicity of M. oleifera protein isolates (MPI), and the effect of different concentrations of MPI (0%, 5%, 10%, and 15%) …
View article: Unveiling the functional epitopes of cobra venom cytotoxin by immunoinformatics and epitope-omic analyses
Unveiling the functional epitopes of cobra venom cytotoxin by immunoinformatics and epitope-omic analyses Open
View article: Selecting antibacterial aptamers against the BamA protein in Pseudomonas aeruginosa by incorporating genetic algorithm to optimise computational screening method
Selecting antibacterial aptamers against the BamA protein in Pseudomonas aeruginosa by incorporating genetic algorithm to optimise computational screening method Open
View article: The antioxidant, wound healing properties and proteomic analysis of water extracts from the tropical cyanobacteria, Nostoc NIES-2111_MUM004
The antioxidant, wound healing properties and proteomic analysis of water extracts from the tropical cyanobacteria, Nostoc NIES-2111_MUM004 Open
View article: A digital module‐based experiential learning in protein biochemistry during the <scp>COVID</scp>‐19 pandemic paradigm
A digital module‐based experiential learning in protein biochemistry during the <span>COVID</span>‐19 pandemic paradigm Open
Experiential learning is compromised in meeting the educational demands of our students during the challenging time of the COVID‐19 pandemic. A more inclusive, flexible, and objective‐oriented experiential learning environment is required.…
View article: A review on current and future advancements for commercialized microalgae species
A review on current and future advancements for commercialized microalgae species Open
Microalgae are unicellular photosynthetic microorganisms that are commonly found in saline or freshwater environments. Over the years, microalgae represent promising sources of sustainable bioactivities with past literatures reflecting a g…
View article: The myth of cobra venom cytotoxin: More than just direct cytolytic actions
The myth of cobra venom cytotoxin: More than just direct cytolytic actions Open
Cobra venom cytotoxin (CTX) is a non-enzymatic three-finger toxin that constitutes 40-60% of cobra venom. Thus, it plays an important role in the pathophysiology of cobra envenomation, especially in local dermonecrosis. The three-finger hy…
View article: The influence of spouses and their driving roles in self-regulation: A qualitative exploration of driving reduction and cessation practices amongst married older adults
The influence of spouses and their driving roles in self-regulation: A qualitative exploration of driving reduction and cessation practices amongst married older adults Open
Our findings suggest spouse play a significant role in their partners' decision to self-regulate driving. This underscores a need to recognise the importance of interdependency amongst couples and its impact on their driving decisions and …
View article: Cytotoxicity of snake venom enzymatic toxins: phospholipase A2 and <scp>l</scp>-amino acid oxidase
Cytotoxicity of snake venom enzymatic toxins: phospholipase A2 and <span>l</span>-amino acid oxidase Open
The phospholipase A2 (PLA2) and l-amino acid oxidase (LAAO) are two major enzymes found in the venoms from most snake species. These enzymes have been structurally and functionally characterised for their pharmacological activities. Both P…
View article: Arctium lappa L. root extract induces cell death via mitochondrial-mediated caspase-dependent apoptosis in Jurkat human leukemic T cells
Arctium lappa L. root extract induces cell death via mitochondrial-mediated caspase-dependent apoptosis in Jurkat human leukemic T cells Open
View article: Exendin‐4 from <i>Heloderma suspectum</i> venom: From discovery to its latest application as type <scp>II</scp> diabetes combatant
Exendin‐4 from <i>Heloderma suspectum</i> venom: From discovery to its latest application as type <span>II</span> diabetes combatant Open
Type II diabetes mellitus (T2 DM ) is a chronic non‐communicable disease due to abnormal insulin actions causing uncontrolled hyperglycaemia. The treatment for T2 DM , for instance, metformin and incretin mimetic, mainly focuses on the res…
View article: Venomics of Tropidolaemus wagleri, the sexually dimorphic temple pit viper: Unveiling a deeply conserved atypical toxin arsenal
Venomics of Tropidolaemus wagleri, the sexually dimorphic temple pit viper: Unveiling a deeply conserved atypical toxin arsenal Open
Tropidolaemus wagleri (temple pit viper) is a medically important snake in Southeast Asia. It displays distinct sexual dimorphism and prey specificity, however its venomics and inter-sex venom variation have not been thoroughly investigate…
View article: The Effect of a Polyvalent Antivenom on the Serum Venom Antigen Levels of<i>Naja sputatrix</i>(Javan Spitting Cobra) Venom in Experimentally Envenomed Rabbits
The Effect of a Polyvalent Antivenom on the Serum Venom Antigen Levels of<i>Naja sputatrix</i>(Javan Spitting Cobra) Venom in Experimentally Envenomed Rabbits Open
The treatment protocol of antivenom in snake envenomation remains largely empirical, partly due to the insufficient knowledge of the pharmacokinetics of snake venoms and the effects of antivenoms on the blood venom levels in victims. In th…