Michelle K. Yong
YOU?
Author Swipe
View article: Incidence and Clinical Outcomes of Multiple Viral Infections After Allogeneic Hematopoietic Cell Transplantation
Incidence and Clinical Outcomes of Multiple Viral Infections After Allogeneic Hematopoietic Cell Transplantation Open
Background Recipients of allogeneic hematopoietic cell transplantation (alloHCT) are at risk of multiple viral infections. However, our knowledge about the clinical impact of viruses following alloHCT is predominantly focused on outcomes o…
View article: The Changing Epidemiology of Breakthrough Invasive Fungal Disease in Allogeneic Hematopoietic Stem Cell Transplant Recipients in the Era of Modified‐Release Posaconazole Prophylaxis
The Changing Epidemiology of Breakthrough Invasive Fungal Disease in Allogeneic Hematopoietic Stem Cell Transplant Recipients in the Era of Modified‐Release Posaconazole Prophylaxis Open
Background Allogeneic hemopoietic stem cell transplant (aHSCT) recipients are at high‐risk for invasive fungal disease (IFD), even with mould‐active antifungal prophylaxis (AFP). Methods This was a retrospective, observational, single‐cent…
View article: Interferon-α Nasal Spray Prophylaxis Reduces COVID-19 in Cancer Patients: A Randomized, Double-Blinded, Placebo-Controlled Trial
Interferon-α Nasal Spray Prophylaxis Reduces COVID-19 in Cancer Patients: A Randomized, Double-Blinded, Placebo-Controlled Trial Open
Background We evaluated whether a daily nasal spray of interferon-alpha (IFN-α) would reduce the incidence of COVID-19 or community-acquired respiratory viral infections in adult cancer patients. Methods In this multicenter, randomized, do…
View article: Estimating the prevalence of key healthcare-associated and opportunistic infections in Australian transplant and cancer populations: protocol for the PROSPER point prevalence study
Estimating the prevalence of key healthcare-associated and opportunistic infections in Australian transplant and cancer populations: protocol for the PROSPER point prevalence study Open
Introduction The immunocompromised host (ICH) is at increased risk for a range of opportunistic and healthcare-associated infections (OI/HAIs). With increased use of novel therapeutics and prolonged survival, the malignancy and transplant …
View article: The INTERACT study: Infection prevention and surveillance practice in the care of the Australasian cancer and transplant population
The INTERACT study: Infection prevention and surveillance practice in the care of the Australasian cancer and transplant population Open
This is the first survey of IPC/surveillance practice in the care of the Australasian cancer/transplant population, demonstrating multiple areas of variation including PPE use and approach to MDRO surveillance. Practice standardisation wil…
View article: American Society for Transplantation and Cellular Therapy Series #11: Updated Cytomegalovirus Guidelines in Hematopoietic Cell Transplant and Cellular Therapy Recipients
American Society for Transplantation and Cellular Therapy Series #11: Updated Cytomegalovirus Guidelines in Hematopoietic Cell Transplant and Cellular Therapy Recipients Open
The Practice Guidelines Committee of the American Society of Transplantation and Cellular Therapy partnered with the society's Transplant Infectious Diseases Special Interest Group to update its previous infectious disease guidelines for t…
View article: P-709. Risk factors for hypoxia and mechanical ventilation in Respiratory Syncytial Virus (RSV) infections in hospitalized solid organ transplant recipients (SOTR)
P-709. Risk factors for hypoxia and mechanical ventilation in Respiratory Syncytial Virus (RSV) infections in hospitalized solid organ transplant recipients (SOTR) Open
Background RSV is a common respiratory infection that causes significant morbidity in SOTR. However, risk factors for complications such as hypoxic respiratory failure, mechanical ventilation, and secondary infections have not been well de…
View article: Clostridioides difficile infection and recurrence in cancer patients (CIRCA): A multicentre, international study
Clostridioides difficile infection and recurrence in cancer patients (CIRCA): A multicentre, international study Open
CDI recurrence rates among cancer patients remain significant. Nonetheless, fidaxomicin and other preventive strategies are seldom used. We identified several factors that could inform the implementation of these strategies in cancer patie…
View article: Identifying Gaps in the International Consensus Case Definitions for Invasive Aspergillosis: A Review of Clinical Cases Not Meeting These Definitions
Identifying Gaps in the International Consensus Case Definitions for Invasive Aspergillosis: A Review of Clinical Cases Not Meeting These Definitions Open
Background International consensus definitions for invasive aspergillosis (IA) in research are rigorous, yet clinically significant cases are often excluded from clinical studies for not meeting proven/probable IA case definitions. To bett…
View article: Cytomegalovirus drives Vδ1+ γδ T cell expansion and clonality in common variable immunodeficiency
Cytomegalovirus drives Vδ1+ γδ T cell expansion and clonality in common variable immunodeficiency Open
The function and phenotype of γδ T cells in the context of common variable immunodeficiency (CVID) has not been explored. CVID is a primary immunodeficiency disorder characterized by impaired antibody responses resulting in increased susce…
View article: Evolution of Humoral and Cellular Immunity Post–Breakthrough Coronavirus Disease 2019 in Vaccinated Patients With Hematologic Malignancy Receiving Tixagevimab-Cilgavimab
Evolution of Humoral and Cellular Immunity Post–Breakthrough Coronavirus Disease 2019 in Vaccinated Patients With Hematologic Malignancy Receiving Tixagevimab-Cilgavimab Open
Background In-depth immunogenicity studies of tixagevimab-cilgavimab (T-C) are lacking, including following breakthrough coronavirus disease 2019 (COVID-19) in vaccinated patients with hematologic malignancy (HM) receiving T-C as pre-expos…
View article: CMV prevention strategies in allogeneic hematopoietic cell transplantation; the role of prophylaxis and pre‐emptive monitoring in the era of letermovir
CMV prevention strategies in allogeneic hematopoietic cell transplantation; the role of prophylaxis and pre‐emptive monitoring in the era of letermovir Open
The preferred strategy for preventing CMV in at‐risk populations in alloHCT has undergone a significant practice shift in recent years where the pendulum has swung from a pre‐emptive approach to now offering letermovir prophylaxis to all C…
View article: High Rates of Seroprotection and Seroconversion to Vaccine-Preventable Infections in the Early Post–Autologous Stem Cell Transplant Period
High Rates of Seroprotection and Seroconversion to Vaccine-Preventable Infections in the Early Post–Autologous Stem Cell Transplant Period Open
In patients early post–autologous stem cell transplant, seroprotection rates were high for Hemophilus influenzae type B and tetanus toxoid (70%–90%) but lower for Streptococcus pneumoniae (30%–50%) including after revaccination. There were…
View article: 2754 A case of JCV encephalitis in an immune-compromised patient treated with allogeneic JCV-specific cytotoxic T lymphocytes
2754 A case of JCV encephalitis in an immune-compromised patient treated with allogeneic JCV-specific cytotoxic T lymphocytes Open
Background JCV encephalitis is a rare manifestation of JC virus infection of the CNS in immunocompromised individuals. There are a few emerging treatments in this domain, including CD8+ Cytotoxic T lymphocytes grown specifically to target …
View article: COVID-19 infection among patients with cancer in Australia from 2020 to 2022: a national multicentre cohort study
COVID-19 infection among patients with cancer in Australia from 2020 to 2022: a national multicentre cohort study Open
This study was supported by research funding from MSD.
View article: Non-viral pathogens of infectious diarrhoea post allogeneic stem cell transplantation are associated with graft-versus-host-disease.
Non-viral pathogens of infectious diarrhoea post allogeneic stem cell transplantation are associated with graft-versus-host-disease. Open
Infectious diarrhoea is common post-allogeneic haematopoietic stem-cell transplantation (alloHSCT). While the epidemiology of Clostridioides difficile infection (CDI) post-alloHSCT has been described, the impact of other diarrhoeal pathoge…
View article: P103: EFFICACY AND SAFETY OF DUPILUMAB IN CHILDREN AGED 6 MONTHS TO 5 YEARS WITH MODERATE‐TO‐SEVERE ATOPIC DERMATITIS
P103: EFFICACY AND SAFETY OF DUPILUMAB IN CHILDREN AGED 6 MONTHS TO 5 YEARS WITH MODERATE‐TO‐SEVERE ATOPIC DERMATITIS Open
93.5% of all enrolled PID patients.On average, patients became competent in self-administration after 2.3 nurse visits (range 1-8 visits). Conclusion:Patients of variable ages with PID are suitable for homebased therapy with Hizentra ® .Th…
View article: Case Report: Cytomegalovirus Disease Is an Under-Recognized Contributor to Morbidity and Mortality in Common Variable Immunodeficiency
Case Report: Cytomegalovirus Disease Is an Under-Recognized Contributor to Morbidity and Mortality in Common Variable Immunodeficiency Open
Background Common Variable Immunodeficiency (CVID) is classified as a ‘Predominantly Antibody Deficiency’ (PAD), but there is emerging evidence of cellular immunodeficiency in a subset of patients. This evidence includes CVID patients diag…
View article: Safety and efficacy of intravenously administered cidofovir in adult haematopoietic cell transplant recipients: a retrospective multicentre cohort study
Safety and efficacy of intravenously administered cidofovir in adult haematopoietic cell transplant recipients: a retrospective multicentre cohort study Open
Objectives To evaluate the safety and efficacy of cidofovir for the treatment of double-stranded DNA (dsDNA) viral infections following allogeneic haematopoietic cell transplant (HCT). Methods This was a retrospective multicentre cohort st…
View article: Managing haematology and oncology patients during the <scp>COVID</scp> ‐19 pandemic: interim consensus guidance
Managing haematology and oncology patients during the <span>COVID</span> ‐19 pandemic: interim consensus guidance Open
Australasian Leukaemia and Lymphoma Group; Australasian Lung Cancer Trials Group; Australian and New Zealand Children's Haematology/Oncology Group; Australia and New Zealand Society of Palliative Medicine; Australasian Society for Infectio…
View article: <scp>Epstein‐Barr</scp> virus related post‐transplant lymphoproliferative disorder prevention strategies in allogeneic hematopoietic stem cell transplantation
<span>Epstein‐Barr</span> virus related post‐transplant lymphoproliferative disorder prevention strategies in allogeneic hematopoietic stem cell transplantation Open
Summary Epstein‐Barr virus associated post‐transplant lymphoproliferative disorders (EBV PTLD) are recognized as a significant cause of morbidity and mortality in patients undergoing allogeneic hematopoietic stem cell transplantation (allo…
View article: New advances in the management of cytomegalovirus in allogeneic haemopoietic stem cell transplantation
New advances in the management of cytomegalovirus in allogeneic haemopoietic stem cell transplantation Open
Cytomegalovirus (CMV) viraemia continues to be a frequent complication in the post‐haemopoietic stem cell transplantation period despite a low incidence of CMV end‐organ disease. Several significant advances in the understanding and manage…
View article: Fatal disseminated visceral varicella zoster virus infection in a renal transplant recipient
Fatal disseminated visceral varicella zoster virus infection in a renal transplant recipient Open
We report a case of fatal disseminated varicella zoster virus (VZV) with delayed–onset rash in a 66‐year‐old female more than 2 years following uncomplicated deceased donor renal transplantation. Whilst on a stable regimen of maintenance i…