Michellie Thurman
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View article: Efficient trapping and destruction of SARS-CoV-2 using PECO-assisted Molekule air purifiers in the laboratory and real-world settings
Efficient trapping and destruction of SARS-CoV-2 using PECO-assisted Molekule air purifiers in the laboratory and real-world settings Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted human-to-human via aerosols and air-borne droplets. Therefore, capturing and destroying viruses from indoor premises are essential to reduce the probability of hum…
View article: Proteomic landscape of astrocytes and pericytes infected with HIV/SARS-CoV-2 mono/co-infection, impacting on neurological complications
Proteomic landscape of astrocytes and pericytes infected with HIV/SARS-CoV-2 mono/co-infection, impacting on neurological complications Open
Background Although most individuals recover from coronavirus disease 2019 (COVID-19) within a few weeks, some people continue to experience a wide range of symptoms known as post-acute sequelae of SARS-CoV-2 (PASC) or long COVID. Majority…
View article: Early treatment with anti-α4β7 antibody facilitates increased gut macrophage maturity in SIV-infected rhesus macaques
Early treatment with anti-α4β7 antibody facilitates increased gut macrophage maturity in SIV-infected rhesus macaques Open
Despite advances in combination antiretroviral therapy (cART), people living with HIV (PLWH) continue to experience gastrointestinal dysfunction. Infusions of anti-α 4 β 7 monoclonal antibodies (mAbs) have been proposed to increase virolog…
View article: Systems biology analyses reveal enhanced chronic morphine distortion of gut-brain interrelationships in simian human immunodeficiency virus infected rhesus macaques
Systems biology analyses reveal enhanced chronic morphine distortion of gut-brain interrelationships in simian human immunodeficiency virus infected rhesus macaques Open
Background Commonly used opioids, such as morphine have been implicated in augmented SIV/HIV persistence within the central nervous system (CNS). However, the extent of myeloid cell polarization and viral persistence in different brain reg…
View article: Improved Database Filtering Technology Enables More Efficient Ab Initio Design of Potent Peptides against Ebola Viruses
Improved Database Filtering Technology Enables More Efficient Ab Initio Design of Potent Peptides against Ebola Viruses Open
The rapid mutations of viruses such as SARS-CoV-2 require vaccine updates and the development of novel antiviral drugs. This article presents an improved database filtering technology for a more effective design of novel antiviral agents. …
View article: PI3K‐α/mTOR/BRD4 inhibitor alone or in combination with other anti‐virals blocks replication of SARS‐CoV‐2 and its variants of concern including Delta and Omicron
PI3K‐α/mTOR/BRD4 inhibitor alone or in combination with other anti‐virals blocks replication of SARS‐CoV‐2 and its variants of concern including Delta and Omicron Open
We demonstrated that SF2523, a dual small molecule inhibitor of PI3K-α/mTOR/BRD4 pathways, can inhibit the replication of SARS-CoV-2 and its emerging variants of concern (VOCs), including Delta and Omicron. Further, we also found that SF25…
View article: Chronic Morphine Exposure distorts Gut-Brain Interrelationships in SHIV Infected Rhesus Macaques
Chronic Morphine Exposure distorts Gut-Brain Interrelationships in SHIV Infected Rhesus Macaques Open
Background Commonly used opioids, such as morphine have been implicated in augmented SIV/HIV persistence within the Central Nervous System (CNS). However, the extent of myeloid cell polarization and viral persistence in different brain reg…
View article: Pathways for Dolutegravir Transformation from a Daily Oral to a Once-a-Year Parenteral Medicine
Pathways for Dolutegravir Transformation from a Daily Oral to a Once-a-Year Parenteral Medicine Open
An “ultra” long-acting (LA) integrase strand transfer inhibitor was created by screening a library of monomeric and dimeric dolutegravir (DTG) prodrug nanoformulations. This led, to the best of our knowledge, a “first in class” 18-carbon c…
View article: Diminished Peripheral CD29hi Cytotoxic CD4+ T Cells Are Associated With Deleterious Effects During SIV Infection
Diminished Peripheral CD29hi Cytotoxic CD4+ T Cells Are Associated With Deleterious Effects During SIV Infection Open
Cytotoxic CD4+ T cells (CD4+ CTLs) limit HIV pathogenesis, as evidenced in elite controllers (a subset of individuals who suppress the virus without the need for therapy). CD4+ CTLs have also been shown to kill HIV-infected macrophages. Ho…
View article: Therapeutic implications of SARS-CoV-2 dysregulation of the gut-brain-lung axis
Therapeutic implications of SARS-CoV-2 dysregulation of the gut-brain-lung axis Open
The emergence and rapid spread of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused over 180 million confirmed cases resulting in over 4 million deaths worldwide with no clear end in sight for the coronavirus di…
View article: Discovery and in-vitro evaluation of potent SARS-CoV-2 entry inhibitors
Discovery and in-vitro evaluation of potent SARS-CoV-2 entry inhibitors Open
SARS-CoV-2 infection initiates with the attachment of spike protein to the ACE2 receptor. While vaccines have been developed, no SARS-CoV-2 specific small molecule inhibitors have been approved. Herein, utilizing the crystal structure of t…
View article: Blockade of SARS-CoV-2 infection in vitro by highly potent PI3K-α/mTOR/BRD4 inhibitor
Blockade of SARS-CoV-2 infection in vitro by highly potent PI3K-α/mTOR/BRD4 inhibitor Open
Pathogenic viruses like SARS-CoV-2 and HIV hijack the host molecular machinery to establish infection and survival in infected cells. This has led the scientific community to explore the molecular mechanisms by which SARS-CoV-2 infects hos…
View article: The slo-1 BK potassium channel interacts genetically with pmr-1 secretory pathway calcium ATPase during C. elegans embryonic cell migration
The slo-1 BK potassium channel interacts genetically with pmr-1 secretory pathway calcium ATPase during C. elegans embryonic cell migration Open
Calcium signaling is known to play a critical role in cell migration (Ridley et al., 2003; Wei et al., 2012). In C. elegans, embryos with disruptions in the secretory pathway calcium ATPase gene pmr-1 show defects in cell migration that re…
View article: Combined Effects of Drugs of Abuse and HIV Infection Comorbidity on Primary Pericytes
Combined Effects of Drugs of Abuse and HIV Infection Comorbidity on Primary Pericytes Open
Background: Pericyte cells are an integral component of the vascular system and blood-brain barrier. HIV infection has been shown to impact both pericytes and the blood-brain barrier. Similarly, drugs of abuse have been found to alter bloo…
View article: Chronic Morphine Administration Differentially Modulates Viral Reservoirs in a Simian Immunodeficiency Virus SIVmac251-Infected Rhesus Macaque Model
Chronic Morphine Administration Differentially Modulates Viral Reservoirs in a Simian Immunodeficiency Virus SIVmac251-Infected Rhesus Macaque Model Open
Identification and clearance of human immunodeficiency virus (HIV) reservoirs is a major challenge in achieving a cure for HIV. This is further complicated by comorbidities that may alter the size of the reservoirs.
View article: Biomarkers of Activation and Inflammation to Track Disparity in Chronological and Physiological Age of People Living With HIV on Combination Antiretroviral Therapy
Biomarkers of Activation and Inflammation to Track Disparity in Chronological and Physiological Age of People Living With HIV on Combination Antiretroviral Therapy Open
With advancement, prompt use, and increasing accessibility of antiretroviral therapy, people with HIV are living longer and have comparable lifespans to those negative for HIV. However, people living with HIV experience tradeoffs with qual…
View article: Chronic morphine administration differentially modulates viral reservoirs in SIVmac251 infected rhesus macaque model
Chronic morphine administration differentially modulates viral reservoirs in SIVmac251 infected rhesus macaque model Open
HIV persists in cellular reservoirs despite effective anti-retroviral therapy with rebound of viremia upon therapy interruption. Opioids modulate the immune system and suppress antiviral gene responses, which significantly impact people li…