Michiel F. Schreuder
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View article: Preserving nephron number in children after preterm birth: a top priority
Preserving nephron number in children after preterm birth: a top priority Open
View article: A nationwide study evaluating indications and outcomes for adrenalectomy in children in the Netherlands
A nationwide study evaluating indications and outcomes for adrenalectomy in children in the Netherlands Open
Adrenalectomies in children are rare in the Netherlands, especially for non-neuroblastoma tumors, and most surgeons perform less than 1 procedure per year. Open adrenalectomy is usually performed for suspected malignant tumors, whereas min…
View article: Renal hypertrophy and hyperfiltration is enhanced in early acquired compared with a congenital solitary function kidney model in sheep
Renal hypertrophy and hyperfiltration is enhanced in early acquired compared with a congenital solitary function kidney model in sheep Open
A congenital solitary functioning kidney (C-SFK) or an early acquired SFK (EA-SFK), due to childhood unilateral nephrectomy (UNX), increases the risk of hypertension and kidney disease early in life. Evidence suggests that children with an…
View article: Whole-genome sequencing reveals contribution of rare and common variation to structural kidney and urinary tract malformations
Whole-genome sequencing reveals contribution of rare and common variation to structural kidney and urinary tract malformations Open
Congenital anomalies of the kidneys and urinary tract (CAKUT) are the commonest cause of kidney failure in children and young adults with over 50 monogenic causes identified, largely in cohorts enriched for familial, syndromic, or consangu…
View article: Translational strategies to uncover the etiology of congenital anomalies of the kidney and urinary tract
Translational strategies to uncover the etiology of congenital anomalies of the kidney and urinary tract Open
While up to 50% of children requiring kidney replacement therapy have congenital anomalies of the kidney and urinary tract (CAKUT), they represent only a fraction of the total patient population with CAKUT. The extreme variability in clini…
View article: Saliva monitoring of prednisolone in children with first onset steroid‐sensitive nephrotic syndrome: Is it possible?
Saliva monitoring of prednisolone in children with first onset steroid‐sensitive nephrotic syndrome: Is it possible? Open
Aims Prednisolone is the cornerstone of treatment for idiopathic nephrotic syndrome in children, but is associated with marked side‐effects. Therapeutic drug monitoring using saliva would be a patient‐friendly option to monitor prednisolon…
View article: Investigating the use of finerenone in children with chronic kidney disease and proteinuria: design of the FIONA and open-label extension studies
Investigating the use of finerenone in children with chronic kidney disease and proteinuria: design of the FIONA and open-label extension studies Open
View article: Levamisole Modulation of Podocytes’ Actin Cytoskeleton in Nephrotic Syndrome
Levamisole Modulation of Podocytes’ Actin Cytoskeleton in Nephrotic Syndrome Open
Podocytes play a central role in glomerular diseases such as (idiopathic) nephrotic syndrome (iNS). Glucocorticoids are the gold standard therapy for iNS. Nevertheless, frequent relapses are common. In children with iNS, steroid-sparing ag…
View article: Genetic and environmental factors driving congenital solitary functioning kidney
Genetic and environmental factors driving congenital solitary functioning kidney Open
Background Congenital solitary functioning kidney (CSFK) is an anomaly predisposing to hypertension, albuminuria and chronic kidney disease. Its aetiology is complex and includes genetic and environmental factors. The role of gene–environm…
View article: Health-related quality of life of children with first onset steroid-sensitive nephrotic syndrome
Health-related quality of life of children with first onset steroid-sensitive nephrotic syndrome Open
View article: Brief early life angiotensin-converting enzyme inhibition attenuates the diuretic response to saline loading in sheep with solitary functioning kidney
Brief early life angiotensin-converting enzyme inhibition attenuates the diuretic response to saline loading in sheep with solitary functioning kidney Open
A solitary functioning kidney (SFK) from birth predisposes to hypertension and kidney dysfunction, and this may be associated with impaired fluid and sodium homeostasis. Brief and early angiotensin-converting enzyme inhibition (ACEi) in a …
View article: Distress in parents of children with first-onset steroid-sensitive nephrotic syndrome
Distress in parents of children with first-onset steroid-sensitive nephrotic syndrome Open
View article: Cystatin C as a Marker for Glomerular Filtration Rate in Critically Ill Neonates and Children: Validation Against Iohexol Plasma Clearance
Cystatin C as a Marker for Glomerular Filtration Rate in Critically Ill Neonates and Children: Validation Against Iohexol Plasma Clearance Open
\n Contains fulltext :\n 295816.pdf (Publisher’s version ) (Open Access)\n
View article: Multi-population genome-wide association study implicates immune and non-immune factors in pediatric steroid-sensitive nephrotic syndrome
Multi-population genome-wide association study implicates immune and non-immune factors in pediatric steroid-sensitive nephrotic syndrome Open
View article: Maternal risk factors for posterior urethral valves
Maternal risk factors for posterior urethral valves Open
Introduction Posterior urethral valves (PUV) is a congenital disorder causing an obstruction of the lower urinary tract that affects approximately 1 in 4,000 male live births. PUV is considered a multifactorial disorder, meaning that both …
View article: Rituximab-associated hypogammaglobulinemia in children with idiopathic nephrotic syndrome: results of an ESPN survey
Rituximab-associated hypogammaglobulinemia in children with idiopathic nephrotic syndrome: results of an ESPN survey Open
Background There is paucity of information on rituximab-associated hypogammaglobulinemia (HGG) and its potential infectious consequences in children treated for idiopathic nephrotic syndrome (INS). Methods A survey was distributed by the E…
View article: Beneficial effects of brief early life angiotensin-converting enzyme inhibition wane with time in sheep with solitary functioning kidney
Beneficial effects of brief early life angiotensin-converting enzyme inhibition wane with time in sheep with solitary functioning kidney Open
A child with a congenital solitary functioning kidney (SFK) may develop kidney disease from early in life due to hyperfiltration injury. Previously, we showed in a sheep model of SFK that brief angiotensin-converting enzyme inhibition (ACE…
View article: Environmental and parental risk factors for congenital solitary functioning kidney — a case–control study
Environmental and parental risk factors for congenital solitary functioning kidney — a case–control study Open
Background The etiology of congenital solitary functioning kidney (CSFK) is largely unknown but likely includes various risk factors. We performed a case–control study to compare exposure to environmental and parental risk factors during e…
View article: A Genome-Wide Association Study into the Aetiology of Congenital Solitary Functioning Kidney
A Genome-Wide Association Study into the Aetiology of Congenital Solitary Functioning Kidney Open
Congenital solitary functioning kidney (CSFK) is a birth defect that occurs in 1:1500 children and predisposes them to kidney injury. Its aetiology is likely multifactorial. In addition to known monogenic causes and environmental risk fact…
View article: Human scattered tubular cells represent a heterogeneous population of glycolytic dedifferentiated proximal tubule cells
Human scattered tubular cells represent a heterogeneous population of glycolytic dedifferentiated proximal tubule cells Open
Scattered tubular cells (STCs) are a phenotypically distinct cell population in the proximal tubule that increase in number after acute kidney injury. We aimed to characterize the human STC population. Three‐dimensional human tissue analys…
View article: Uncovering risk factors for kidney injury in children with a solitary functioning kidney
Uncovering risk factors for kidney injury in children with a solitary functioning kidney Open
Children with a solitary functioning kidney (SFK) have an increased risk of kidney injury. The exact risk of and risk factors for kidney injury remain unknown, which impedes personalized care. Here, we recruited a nationwide multicenter co…
View article: Proenkephalin A as a marker for glomerular filtration rate in critically ill children: validation against gold standard iohexol GFR measurements
Proenkephalin A as a marker for glomerular filtration rate in critically ill children: validation against gold standard iohexol GFR measurements Open
Objectives Accurate determination of glomerular filtration rate (GFR) is important. Several endogenous biomarkers exist for estimating GFR, yet, they have limited accuracy, especially in the paediatric population. Proenkephalin A 119–159 (…
View article: Pregnancy after kidney transplantation: more attention is needed for long-term follow-up of the offspring
Pregnancy after kidney transplantation: more attention is needed for long-term follow-up of the offspring Open
View article: Correspondence to: Reliability of glomerular filtration rate estimating formulas compared to iohexol plasma clearance in critically ill children
Correspondence to: Reliability of glomerular filtration rate estimating formulas compared to iohexol plasma clearance in critically ill children Open
View article: Genome-wide association study in patients with posterior urethral valves
Genome-wide association study in patients with posterior urethral valves Open
Congenital lower urinary tract obstructions (LUTO) are most often caused by posterior urethral valves (PUV), a male limited anatomical obstruction of the urethra affecting 1 in 4,000 male live births. Little is known about the genetic back…
View article: Circulating Permeability Factors in Focal Segmental Glomerulosclerosis: In Vitro Detection
Circulating Permeability Factors in Focal Segmental Glomerulosclerosis: In Vitro Detection Open
View article: Multi-population genome-wide association study implicates both immune and non-immune factors in the etiology of pediatric steroid sensitive nephrotic syndrome
Multi-population genome-wide association study implicates both immune and non-immune factors in the etiology of pediatric steroid sensitive nephrotic syndrome Open
Pediatric steroid-sensitive nephrotic syndrome (pSSNS) is the most common childhood glomerular disease. Previous genome-wide association studies (GWAS) identified a risk locus in the HLA Class II region and three additional signals. But th…
View article: Plasma exchange or immunoadsorption for recurrent focal segmental glomerulosclerosis: clear differences <i>in vitro</i>
Plasma exchange or immunoadsorption for recurrent focal segmental glomerulosclerosis: clear differences <i>in vitro</i> Open
Contains fulltext : 287636.pdf (Publisher’s version ) (Open Access)
View article: Glomerular filtration rate in critically ill neonates and children: creatinine-based estimations versus iohexol-based measurements
Glomerular filtration rate in critically ill neonates and children: creatinine-based estimations versus iohexol-based measurements Open
View article: Definition, diagnosis and clinical management of non-obstructive kidney dysplasia: a consensus statement by the ERKNet Working Group on Kidney Malformations
Definition, diagnosis and clinical management of non-obstructive kidney dysplasia: a consensus statement by the ERKNet Working Group on Kidney Malformations Open
Kidney dysplasia is one of the most frequent causes of chronic kidney failure in children. While dysplasia is a histological diagnosis, the term ‘kidney dysplasia’ is frequently used in daily clinical life without histopathological confirm…