Explanipedia

Distinguishing Mental From Physical Fatigue in Patients With Low‐Grade Glioma Open

Femke F. Siebenga, Sandra E. Rakers, Floor Gelmers, Hiska L. van der Weide, Miranda C.A. Kramer , et al. · 2025

Background Fatigue is a common consequence of low‐grade gliomas (LGG), but its specific nature has not been extensively studied. In particular, it remains unclear if the prevalence and determinants of mental fatigue differ from those of ph…

OS04.8.A UNRAVELLING MENTAL AND PHYSICAL FATIGUE IN PATIENTS WITH LOW-GRADE GLIOMA TREATED WITH PROTON RADIATION THERAPY Open

F F Siebenga, Hiska L. van der Weide, Miranda C.A. Kramer, Anouk van der Hoorn, Roelien H. Enting , et al. · 2025

BACKGROUND Fatigue is a common consequence of low-grade gliomas (LGG), but its specific nature and progression over time has not been extensively studied. Additionally, the effects of proton radiation therapy on fatigue are unclear. Althou…

P15.06.B BREAKING BAD NEWS IN NEURO-ONCOLOGY: A QUALITATIVE STUDY INTO THE EXPERIENCES AND NEEDS OF PATIENTS WITH GLIOMAS AND THEIR RELATIVES Open

A de Boer, Michiel Wagemakers, Saskia Kuipers, Sophie Bunskoek, Anne M. Buunk · 2025

BACKGROUND Healthcare professionals working with patients with gliomas face the challenge of navigating difficult conversations. After surgery the neurosurgeon discusses the diagnosis with the patient and their relatives. Tailored communic…

P15.18.B RETURN TO WORK, SOCIAL, AND LEISURE ACTIVITIES AFTER AWAKE SURGERY FOR GLIOMAS Open

Anne M. Buunk, Jacoba M. Spikman, F F Siebenga, Hanne‐Rinck Jeltema, Michiel Wagemakers , et al. · 2025

BACKGROUND To measure outcome after awake craniotomy for gliomas, attention has shifted from purely oncological outcomes to long-term quality of life and functional recovery. One important yet underexplored dimension of recovery is the res…

Survival prediction in glioblastoma: 10-year follow-up from the Dutch Neurosurgery Quality Registry Open

Jeroen T.J.M. van Dijck, Hilko Ardon, Rutger K. Balvers, Eelke M. Bos, Lisette Bosscher , et al. · 2025

Neurocognitive function in lower grade glioma patients selected for proton radiotherapy: real-world data from a prospective cohort study Open

Hiska L. van der Weide, Anne M. Buunk, Femke F. Siebenga, Johannes A. Langendijk, Agata Bannink-Gawryszuk , et al. · 2025

Purpose To determine neurocognitive function (NCF) profiles of patients with lower grade glioma (LGG) eligible to undergo proton radiotherapy (PRT), and how these relate to clinical and radiological characteristics. PRT is offered to those…

Between-hospital variation in biopsy indication for patients with newly diagnosed glioblastoma in the Dutch Quality Registry for Neurosurgery Open

Ilaria Viozzi, Gerjon Hannink, Hilko Ardon, Rutger K. Balvers, Lisette Bosscher , et al. · 2025

Estimating overall survival of glioblastoma patients using clinical variables, tumor size, and location Open

Alexandros Ferles, Paulina Majewska, Ragnhild Holden Helland, Ivar Kommers, André Pedersen , et al. · 2025

Background Accurate prognosis of glioblastoma is crucial for better-informed treatment decisions, potentially leading to improved disease management. We investigated whether clinical variables, tumor size, and location, can serve as progno…

Effectiveness of Biopsy Combined with Same-session MR-guided LITT Versus Biopsy Alone in Patients with Primary Irresectable Glioblastoma: Results of a Multicenter Randomized Controlled Trial Open

C. Ineke Neutel, Christiaan G. Overduin, Anne Rijpma, Janneke P.C. Grutters, Gerjon Hannink , et al. · 2025

Clusters of resilience and vulnerability: executive functioning, coping and mental distress in patients with diffuse low-grade glioma Open

Floor Gelmers, Marieke E. Timmerman, Femke F. Siebenga, Hiska L. van der Weide, Sandra E. Rakers , et al. · 2024

Multi-class glioma segmentation on real-world data with missing MRI sequences: comparison of three deep learning algorithms Open

Hugh Pemberton, Jiaming Wu, Ivar Kommers, Domenique M. J. Müller, Yipeng Hu , et al. · 2023

Segmentation of glioblastomas in early post-operative multi-modal MRI with deep neural networks Open

Ragnhild Holden Helland, Alexandros Ferles, André Pedersen, Ivar Kommers, Hilko Ardon , et al. · 2023

Emotion recognition in relation to tumor characteristics in patients with low-grade glioma Open

Femke F. Siebenga, Hiska L. van der Weide, Floor Gelmers, Sandra E. Rakers, Miranda C.A. Kramer , et al. · 2023

Background Patients with low-grade gliomas (LGG) treated with surgery, generally function well and have a favorable prognosis. However, LGG can affect neurocognitive functioning. To date, little is known about social cognition (SC) in thes…

The vanishing of the <span>AC</span> o <span>A</span> syndrome after aneurysmal subarachnoid haemorrhage: New era, different management, fewer problems? Open

Anne M. Buunk, Jacoba M. Spikman, Michiel Wagemakers, Hanne‐Rinck Jeltema, Juriena D. de Vries , et al. · 2023

Historically, a specific set of symptoms has been related to the rupture and repair of anterior communicating artery (ACoA) aneurysms. These consequences were defined as the ‘ACoA syndrome’ and included observations of severe memory loss, …

P01.10.B EMOTION RECOGNITION IN PATIENTS WITH LOW-GRADE GLIOMA: THE RELATIONSHIP WITH TUMOR LOCATION AND TUMOR VOLUME Open

F F Siebenga, Hiska L. van der Weide, Floor Gelmers, Sandra E. Rakers, Miranda C.A. Kramer , et al. · 2023

BACKGROUND Patients with low-grade gliomas (LGG), generally function well at the time of diagnosis and have a favourable prognosis. However, LGG can have impact on cognitive functioning of patients. To date, little is known about social co…

Segmentation of glioblastomas in early post-operative multi-modal MRI with deep neural networks Open

Ragnhild Holden Helland, Alexandros Ferles, André Pedersen, Ivar Kommers, Hilko Ardon , et al. · 2023

Extent of resection after surgery is one of the main prognostic factors for patients diagnosed with glioblastoma. To achieve this, accurate segmentation and classification of residual tumor from post-operative MR images is essential. The c…

Segmentation of glioblastomas in early post-operative multi-modal MRI with deep neural networks Open

Ragnhild Holden Helland, Alexandros Ferles, André Pedersen, Ivar Kommers, Hilko Ardon , et al. · 2023

Extent of resection after surgery is one of the main prognostic factors for patients diagnosed with glioblastoma. To achieve this, accurate segmentation and classification of residual tumor from post-operative MR images is essential. The c…

Fluorescence guided surgery for the detection of meningioma using bevacizumab-IRDye800CW (LUMINA trial) - a single center phase I/II study Open

Bianca Dijkstra, Quirine C. F. Cordia, Julie Nonnekens, Gert Jan Meersma, Venkata Sasank Donthu , et al. · 2023

Segmentation of Glioblastomas in Early Post-Operative Multi-Modal MRI with Deep Neural Networks Open

Ragnhild Holden Helland, Alexandros Ferles, André Pedersen, Ivar Kommers, Hilko Ardon , et al. · 2023

Emotion Recognition in Patients with Low-Grade Glioma before and after Surgery Open

Anne M. Buunk, Marleen J. J. Gerritsen, Hanne‐Rinck Jeltema, Michiel Wagemakers, Jan D. M. Metzemaekers , et al. · 2022

Research on patients with low-grade gliomas (LGGs) showed neurocognitive impairments in various domains. However, social cognition has barely been investigated. Facial emotion recognition is a vital aspect of social cognition, but whether …

P11.37.B When to resect or biopsy for patients with supratentorial glioblastoma: a multivariable prediction model Open

Ivar Kommers, Roelant S. Eijgelaar, Frederik Barkhof, David Bouget, André Pedersen , et al. · 2022

Background The prospects of a patient with suspected glioblastoma may rely heavily on the indication for surgical resection versus biopsy only. Biopsy percentages vary considerably across hospitals and guidelines for treatment of glioblast…

Preoperative Brain Tumor Imaging: Models and Software for Segmentation and Standardized Reporting Open

David Bouget, André Pedersen, Asgeir Store Jakola, Vasileios K. Kavouridis, Kyrre E. Emblem , et al. · 2022

For patients suffering from brain tumor, prognosis estimation and treatment decisions are made by a multidisciplinary team based on a set of preoperative MR scans. Currently, the lack of standardized and automatic methods for tumor detecti…

Emotion recognition in patients with low-grade glioma before and after surgery Open

Anne M. Buunk, Mylène Gerritsen, Hanne‐Rinck Jeltema, Michiel Wagemakers, J. D. M. Metzemaekers , et al. · 2022

Purpose. Research on patients with low-grade gliomas (LGG) showed neurocognitive impairments in various domains. However, social cognition has barely been investigated, while it is acknowledged as an important neurocognitive domain. Facial…

Distinct Slow-Wave Activity Patterns in Resting-State Electroencephalography and Their Relation to Language Functioning in Low-Grade Glioma and Meningioma Patients Open

Nienke Wolthuis, Ingeborg Bosma, Roelien Bastiaanse, Perumpillichira J. Cherian, Marion Smits , et al. · 2022

Introduction Brain tumours frequently cause language impairments and are also likely to co-occur with localised abnormal slow-wave brain activity. However, it is unclear whether this applies specifically to low-grade brain tumours. We inve…

Between-hospital variation in time to glioblastoma surgery: a report from the Quality Registry Neuro Surgery in the Netherlands Open

Merijn E de Swart, Domenique M. J. Müller, Hilko Ardon, Rutger K. Balvers, Lisette Bosscher , et al. · 2022

OBJECTIVE Patients with glioblastoma are often scheduled for urgent elective surgery. Currently, the impact of the waiting period until glioblastoma surgery is undetermined. In this national quality registry study, the authors determined t…

Rare central nervous system tumors in adults: a population-based study of ependymomas, pilocytic astrocytomas, medulloblastomas, and intracranial germ cell tumors Open

Vincent K.Y. Ho, Anja Gijtenbeek, Michiel Wagemakers, Walter Taal, Myra E. van Linde , et al. · 2022

Background Ependymomas, pilocytic astrocytomas, medulloblastomas, and intracranial germ cell tumors occur relative frequently in children, but are rare central nervous system (CNS) tumors in adults. In this population-based survey, we esta…

Resting-State Electroencephalography Functional Connectivity Networks Relate to Pre- and Postoperative Language Functioning in Low-Grade Glioma and Meningioma Patients Open

Nienke Wolthuis, Djaina Satoer, Wencke S. Veenstra, Marion Smits, Michiel Wagemakers , et al. · 2021

Introduction: Preservation of language functioning in patients undergoing brain tumor surgery is essential because language impairments negatively impact the quality of life. Brain tumor patients have alterations in functional connectivity…

Glioblastoma Surgery Imaging–Reporting and Data System: Validation and Performance of the Automated Segmentation Task Open

David Bouget, Roelant S. Eijgelaar, André Pedersen, Ivar Kommers, Hilko Ardon , et al. · 2021

For patients with presumed glioblastoma, essential tumor characteristics are determined from preoperative MR images to optimize the treatment strategy. This procedure is time-consuming and subjective, if performed by crude eyeballing or ma…

11C-methyl-L-methionine PET measuring parameters for the diagnosis of tumour progression against radiation-induced changes in brain metastases Open

Chris W. Govaerts, Bart RJ. van Dijken, Gilles N. Stormezand, Hiska L. van der Weide, Michiel Wagemakers , et al. · 2021

Objectives: Radiation-induced changes (RIC) secondary to focal radiotherapy can imitate tumour progression in brain metastases and make follow-up clinical decision making unreliable. 11C-methyl-L-methionine-PET (MET-PET) is widely used for…

Glioblastoma Surgery Imaging—Reporting and Data System: Standardized Reporting of Tumor Volume, Location, and Resectability Based on Automated Segmentations Open

Ivar Kommers, David Bouget, André Pedersen, Roelant S. Eijgelaar, Hilko Ardon , et al. · 2021

Treatment decisions for patients with presumed glioblastoma are based on tumor characteristics available from a preoperative MR scan. Tumor characteristics, including volume, location, and resectability, are often estimated or manually del…

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