Explanipedia

Performance-weighted ensemble learning for detecting patients with FTD and ALS from brief reading speech Open

Yuki Ito, Reiko Ohdake, Shōhei Kato, Michihito Masuda, Maki Suzuki , et al. · 2025

We developed a novel machine learning model named performance-weighted ensemble learning (PWEL) to detect frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) using speech from word and sentence reading tasks. Overall, 197…

Nation-wide Japanese FTD consortium FTLD-J: Utility of case review meetings Open

Shunsuke Sato, Kohji Mori, Michihito Masuda, Maki Suzuki, Daiki Taomoto , et al. · 2025

Our results suggested that case review meetings in a multicenter study may improve diagnostic consistency, especially in bvFTD.

A Case of Neuronal Intranuclear Inclusion Disease Diagnosed Definitively from Skin Tissue Open

Maki Yoshimitsu, Emi Nishida, Michihito Masuda, Kuka ISHIOKA · 2023

82 歳,男性。約 3 カ月前からの物忘れを主訴に近医内科より当院脳神経内科を紹介され受診した。頭部 MRI にて特徴的な所見を認めたため神経核内封入体病(neuronal intranuclear inclusion disease)を疑われ,診断のための皮膚生検を目的として当科へ紹介となった。腹部から脂肪織を含めて皮膚生検を施行した。病理組織学的に,汗腺細胞や血管内皮細胞の核の一部にごく小さな空胞状変化を認め,核内にユビキチン陽性の小型球状物を少数認めたものの典型像と…

＜Editors' Choice＞ Pattern of THK 5351 retention in normal aging involves core regions of resting state networks associated with higher cognitive function. Open

Yusuke Yoshida, Takamasa Yokoi, Kazuhiro Hara, Hirohisa Watanabe, Hiroshi Yamaguchi , et al. · 2023

We aimed to elucidate the distribution pattern of the positron emission tomography probe [18F]THK 5351, a marker for astrogliosis and tau accumulation, in healthy aging. We also assessed the relationship between THK5351 retention and resti…

Comparative examination of the pons and corpus callosum as reference regions for quantitative evaluation in positron emission tomography imaging for Alzheimer’s disease using 11C-Pittsburgh Compound-B Open

Tomohiro Tada, Kazuhiro Hara, Naotoshi Fujita, Yoshinori Ito, Hiroshi Yamaguchi , et al. · 2023

Connectivity impairment of cerebellar and sensorimotor connector hubs in Parkinson’s disease Open

Epifanio Bagarinao, Kazuya Kawabata, Hirohisa Watanabe, Kazuhiro Hara, Reiko Ohdake , et al. · 2022

Cognitive and movement processes involved integration of several large-scale brain networks. Central to these integrative processes are connector hubs, brain regions characterized by strong connections with multiple networks. Growing evide…

Functional connector hubs in the cerebellum Open

Kazuya Kawabata, Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori , et al. · 2022

Accumulating evidence from anatomical and neuroimaging studies suggests that the cerebellum is engaged in a variety of motor and cognitive tasks. Given its various functions, a key question is whether the cerebellum also plays an important…

Bridging large-scale cortical networks: Integrative and function-specific hubs in the thalamus Open

Kazuya Kawabata, Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori , et al. · 2021

The thalamus is critical for the brain's integrative hub functions; however, the localization and characterization of the different thalamic hubs remain unclear. Using a voxel-level network measure called functional connectivity overlap ra…

Aging Impacts the Overall Connectivity Strength of Regions Critical for Information Transfer Among Brain Networks Open

Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara , et al. · 2020

Recent studies have demonstrated that connector hubs, regions considered critical for the flow of information across neural systems, are mostly involved in neurodegenerative dementia. Considering that aging can significantly affect the bra…

The neural network basis of altered decision‐making in patients with amyotrophic lateral sclerosis Open

Kazunori Imai, Michihito Masuda, Hirohisa Watanabe, Aya Ogura, Reiko Ohdake , et al. · 2020

Objective Amyotrophic lateral sclerosis (ALS) is a multisystem disorder associated with motor impairment and behavioral/cognitive involvement. We examined decision‐making features and changes in the neural hub network in patients with ALS …

Identifying the brain's connector hubs at the voxel level using functional connectivity overlap ratio Open

Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara , et al. · 2020

Changes in white matter fiber density and morphology across the adult lifespan: A cross‐sectional fixel‐based analysis Open

Shao Wei Choy, Epifanio Bagarinao, Hirohisa Watanabe, Eric Tatt Wei Ho, Satoshi Maesawa , et al. · 2020

White matter (WM) fiber bundles change dynamically with age. These changes could be driven by alterations in axonal diameter, axonal density, and myelin content. In this study, we applied a novel fixel‐based analysis (FBA) framework to exa…

Visuoperceptual disturbances in Parkinson's disease Open

Kazuya Kawabata, Reiko Ohdake, Hirohisa Watanabe, Epifanio Bagarinao, Kazuhiro Hara , et al. · 2020

Semantic deficits in ALS related to right lingual/fusiform gyrus network involvement Open

Aya Ogura, Hirohisa Watanabe, Kazuya Kawabata, Reiko Ohdake, Yasuhiro Tanaka , et al. · 2019

Reorganization of brain networks and its association with general cognitive performance over the adult lifespan Open

Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara , et al. · 2019

Healthy aging is associated with structural and functional changes in the brain even in individuals who are free of neurodegenerative diseases. Using resting state functional magnetic resonance imaging data from a carefully selected cohort…

Semantic Deficits in ALS Related to Right Lingual/Fusiform Gyrus Network Involvement: A Case-Control Study Open

Aya Ogura, Hirohisa Watanabe, Kazuya Kawabata, Reiko Ohdake, Yasuhiro Tanaka , et al. · 2019

Involvement of the Precuneus/Posterior Cingulate Cortex Is Significant for the Development of Alzheimer’s Disease: A PET (THK5351, PiB) and Resting fMRI Study Open

Takamasa Yokoi, Hirohisa Watanabe, Hiroshi Yamaguchi, Epifanio Bagarinao, Michihito Masuda , et al. · 2018

Background: Imaging studies in Alzheimer's disease (AD) have yet to answer the underlying questions concerning the relationship among tau retention, neuroinflammation, network disruption and cognitive decline. We compared the spatia…

Severe hyposmia and aberrant functional connectivity in cognitively normal Parkinson’s disease Open

Noritaka Yoneyama, Hirohisa Watanabe, Kazuya Kawabata, Epifanio Bagarinao, Kazuhiro Hara , et al. · 2018

PD-SH showed extensive decreased amygdala FC. Particularly, decreased FC between the amygdala and inferior parietal lobule, lingual gyrus, and fusiform gyrus were associated with the severity of hyposmia and cognitive performance. In contr…

Pathologic Involvement of Glutamatergic Striatal Inputs From the Cortices in TAR DNA-Binding Protein 43 kDa-Related Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis Open

Yuichi Riku, Hirohisa Watanabe, Mari Yoshida, Maya Mimuro, Yasushi Iwasaki , et al. · 2017

In frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS), recent studies have presumed relationships between cognitive declines and striatal dysfunctions. The striatum contributes to socio-cognitive functions by …

Involvement of the caudate nucleus head and its networks in sporadic amyotrophic lateral sclerosis-frontotemporal dementia continuum Open

Michihito Masuda, Joe Senda, Hirohisa Watanabe, Bagarinao Epifanio, Yasuhiro Tanaka , et al. · 2016

We investigated common structural and network changes across the sporadic amyotrophic lateral sclerosis (ALS)-frontotemporal dementia (FTD) continuum. Based on cluster analysis using the frontotemporal assessment battery, 51 patients with …

Marked Involvement of the Striatal Efferent System in TAR DNA-Binding Protein 43 kDa-Related Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis Open

Yuichi Riku, Hirohisa Watanabe, Mari Yoshida, Maya Mimuro, Yasushi Iwasaki , et al. · 2016

Recent pathological studies indicate that neuronal loss and/or TAR DNA-binding protein-43 kDa (TDP-43) inclusions are frequent in the striatum of patients with TDP-43-related frontotemporal lobar degeneration (FTLD-TDP) and amyotrophic lat…

Memory Loss and Frontal Cognitive Dysfunction in a Patient with Adult-onset Neuronal Intranuclear Inclusion Disease Open

Kunihiko Araki, Jun Sone, Yusuke Fujioka, Michihito Masuda, Reiko Ohdake , et al. · 2016

Neuronal intranuclear inclusion disease (NIID) is an uncommon progressive neurodegenerative disorder. Adult-onset NIID can result in prominent dementia. We herein describe the case of a 74-year-old man who presented with dementia, cerebell…

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