Michiko Mandai
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View article: Regenerative therapies using pluripotent stem cell-derived retinal organoids
Regenerative therapies using pluripotent stem cell-derived retinal organoids Open
Photoreceptor degeneration leads to irreversible vision loss in numerous inherited retinal diseases. While gene therapy addresses specific mutations, cell replacement strategies offer a potentially broader solution applicable across multip…
View article: Hidden Markov models reveal behavioral state dynamics in depth-related locomotion in mice
Hidden Markov models reveal behavioral state dynamics in depth-related locomotion in mice Open
Understanding how mice process and respond to visual depth cues is crucial for studying visual perception, yet traditional behavioral analyses often miss key aspects of this process, such as the dynamic transitions between behavioral state…
View article: Hidden Markov Models Reveal Behavioral State Dynamics in Depth-Related Locomotion in Mice
Hidden Markov Models Reveal Behavioral State Dynamics in Depth-Related Locomotion in Mice Open
Understanding how mice process and respond to visual depth cues is crucial for studying visual perception, yet traditional behavioral analyses often miss key aspects of this process, such as the dynamic transitions between behavioral state…
View article: Characterization of the depolarization contrast line in the outer retina using polarization-sensitive optical coherence tomography
Characterization of the depolarization contrast line in the outer retina using polarization-sensitive optical coherence tomography Open
This study aimed to characterize the anatomical features of a new observation, the depolarization contrast line (DCL) near the photoreceptor inner/outer segment (IS/OS) area visualized using polarization-sensitive optical coherence tomogra…
View article: Allogenic Transplantation of RPE Strips Lacking MHC Class II Can Avoid Rejection in Nonhuman Primate Eyes
Allogenic Transplantation of RPE Strips Lacking MHC Class II Can Avoid Rejection in Nonhuman Primate Eyes Open
Allogeneic transplantation of CIITA-/- RPE strips may reduce rejection risk in RPE-ablated disease model eyes, suggesting potential clinical benefits of MHC class II-deficient RPE grafts, particularly for diseases with inflammatory patholo…
View article: Transplantation of genome-edited retinal organoids restores some fundamental physiological functions coordinated with severely degenerated host retinas
Transplantation of genome-edited retinal organoids restores some fundamental physiological functions coordinated with severely degenerated host retinas Open
We have previously shown that the transplantation of stem cell-derived retinal organoid (RO) sheets into animal models of end-stage retinal degeneration can lead to host-graft synaptic connectivity and restoration of vision, which was furt…
View article: Optimization of HITI-Mediated Gene Insertion for Rhodopsin and Peripherin-2 in Mouse Rod Photoreceptors: Targeting Dominant Retinitis Pigmentosa
Optimization of HITI-Mediated Gene Insertion for Rhodopsin and Peripherin-2 in Mouse Rod Photoreceptors: Targeting Dominant Retinitis Pigmentosa Open
The study showcases a workflow for the rapid optimization and validation of highly effective HITI-treatment gene constructs against dominant-negative inheritance in inherited retinal dystrophy. These findings suggest the potential utility …
View article: Transplantation of human pluripotent stem cell-derived retinal sheet in a primate model of macular hole
Transplantation of human pluripotent stem cell-derived retinal sheet in a primate model of macular hole Open
Macular hole (MH) is a retinal break involving the fovea that causes impaired vision. Although advances in vitreoretinal surgical techniques achieve >90% MH closure rate, refractory cases still exist. For such cases, autologous retinal tra…
View article: Cellular and circuit remodeling of the primate foveal midget pathway after acute photoreceptor loss
Cellular and circuit remodeling of the primate foveal midget pathway after acute photoreceptor loss Open
The retinal fovea in human and nonhuman primates is essential for high acuity and color vision. Within the fovea lies specialized circuitry in which signals from a single cone photoreceptor are largely conveyed to one ON and one OFF type m…
View article: Adaptive Optics Optical Coherence Tomography Analysis of Induced Pluripotent Stem Cell-Derived Retinal Organoid Transplantation in Retinitis Pigmentosa
Adaptive Optics Optical Coherence Tomography Analysis of Induced Pluripotent Stem Cell-Derived Retinal Organoid Transplantation in Retinitis Pigmentosa Open
This study evaluates the transplantation of induced pluripotent stem cell (iPSC)-derived retinal organoids into patients with advanced retinitis pigmentosa using adaptive optics optical coherence tomography (AO-OCT) to monitor retinal chan…
View article: Graft cell expansion from hiPSC-RPE strip after transplantation in primate eyes with or without RPE damage
Graft cell expansion from hiPSC-RPE strip after transplantation in primate eyes with or without RPE damage Open
Clinical studies using suspensions or sheets of human pluripotent cell-derived retinal pigment epithelial cells (hiPSC-RPE) have been conducted globally for diseases such as age-related macular degeneration. Despite being minimally invasiv…
View article: DISCREPANCY BETWEEN FUNDUS AUTOFLUORESCENCE ABNORMALITY AND VISUAL FIELD LOSS IN BIETTI CRYSTALLINE DYSTROPHY
DISCREPANCY BETWEEN FUNDUS AUTOFLUORESCENCE ABNORMALITY AND VISUAL FIELD LOSS IN BIETTI CRYSTALLINE DYSTROPHY Open
Purpose: The aim of this study was to explore the potential benefits of retinal pigment epithelium replacement therapy in patients with Bietti crystalline dystrophy (BCD) by assessing the disease pathology with the distinctive relationship…
View article: Relationship between residual visual field and full-field stimulus testing in patients with late-stage retinal degenerative diseases
Relationship between residual visual field and full-field stimulus testing in patients with late-stage retinal degenerative diseases Open
This study aimed to investigate how the extent and central/peripheral location of the residual visual field (VF) in patients with late-stage inherited retinal diseases (IRDs) are related to retinal sensitivity detected using full-field sti…
View article: Investigation of the effectiveness of gelatin hydrolysate in human iPS-RPE cell suspension transplantation
Investigation of the effectiveness of gelatin hydrolysate in human iPS-RPE cell suspension transplantation Open
Gelatin hydrolysate is considered a valuable and useful candidate for future regenerative therapies in hiPSC-RPE suspension transplantation.
View article: Dataset for "Label-free enrichment of human pluripotent stem cell-derived early retinal progenitor cells for cell-based regenerative therapies"
Dataset for "Label-free enrichment of human pluripotent stem cell-derived early retinal progenitor cells for cell-based regenerative therapies" Open
The raw dataset for "Label-free enrichment of human pluripotent stem cell-derived early retinal progenitor cells for cell-based regenerative therapies" DOI:https://doi.org/10.1016/j.stemcr.2023.12.001
View article: Label-free enrichment of human pluripotent stem cell-derived early retinal progenitor cells for cell-based regenerative therapies
Label-free enrichment of human pluripotent stem cell-derived early retinal progenitor cells for cell-based regenerative therapies Open
Pluripotent stem cell-based therapy for retinal degenerative diseases is a promising approach to restoring visual function. A clinical study using retinal organoid (RO) sheets was recently conducted in patients with retinitis pigmentosa. H…
View article: Dataset for "Label-free enrichment of human pluripotent stem cell-derived early retinal progenitor cells for cell-based regenerative therapies"
Dataset for "Label-free enrichment of human pluripotent stem cell-derived early retinal progenitor cells for cell-based regenerative therapies" Open
The raw dataset for "Label-free enrichment of human pluripotent stem cell-derived early retinal progenitor cells for cell-based regenerative therapies" DOI:https://doi.org/10.1016/j.stemcr.2023.12.001
View article: dataset for "Label-free enrichment of human pluripotent stem cell-derived early retinal progenitor cells for cell-based regenerative therapies"
dataset for "Label-free enrichment of human pluripotent stem cell-derived early retinal progenitor cells for cell-based regenerative therapies" Open
The raw dataset for "Enrichment of human stem cell-derived early retinal progenitor cells using label-free ghost cytometry sorting for cell-based therapies"
View article: Efficient workflow for validating homology-independent targeted integration-mediated gene insertion in rod photoreceptor cells to treat dominant-negative mutations causing retinitis pigmentosa
Efficient workflow for validating homology-independent targeted integration-mediated gene insertion in rod photoreceptor cells to treat dominant-negative mutations causing retinitis pigmentosa Open
Among the genome-editing methods for repairing disease-causing mutations resulting in dominant inhibition, homology-independent targeted integration (HITI)-mediated gene insertion of the normal form of the causative gene is useful because …
View article: dataset for "Label-free enrichment of human pluripotent stem cell-derived early retinal progenitor cells for cell-based regenerative therapies"
dataset for "Label-free enrichment of human pluripotent stem cell-derived early retinal progenitor cells for cell-based regenerative therapies" Open
The raw dataset for "Enrichment of human stem cell-derived early retinal progenitor cells using label-free ghost cytometry sorting for cell-based therapies"
View article: Comparing the transcriptome of developing native and iPSC-derived mouse retinae by single cell RNA sequencing
Comparing the transcriptome of developing native and iPSC-derived mouse retinae by single cell RNA sequencing Open
We report the generation and analysis of single-cell RNA-Seq data (> 38,000 cells) from mouse native retinae and induced pluripotent stem cell (iPSC)-derived retinal organoids at four matched stages of development spanning the emergence of…
View article: Pluripotent stem cell-derived retinal organoid/cells for retinal regeneration therapies: A review
Pluripotent stem cell-derived retinal organoid/cells for retinal regeneration therapies: A review Open
In recent decades, many researchers have attempted to restore vision via transplantation of retina/retinal cells in eyes with retinal degeneration. The advent of induced pluripotent stem cells (iPSC) and retinal organoid induction technolo…