Michiko Yamada
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View article: Overview and future studies of potential hereditary effects of parental exposure to atomic bomb radiation on their offspring
Overview and future studies of potential hereditary effects of parental exposure to atomic bomb radiation on their offspring Open
This is a brief review of studies conducted at the Atomic Bomb Casualty Commission and Radiation Effects Research Foundation regarding the possible transgenerational effects of atomic bomb radiation. These include clinical, epidemiological…
View article: Reproducibility of Age at Menarche Gathered From Mail Questionnaires: A Report From the Life Span Study
Reproducibility of Age at Menarche Gathered From Mail Questionnaires: A Report From the Life Span Study Open
This is the first study to evaluate menarcheal-age reproducibility between self- and proxy-reports using appropriate measures. Mail questionnaires at 9-year interval showed moderate reproducibility across all ages, including elderly self-r…
View article: Relationship Between Radiation Dose and Markers of Insulin Resistance and Inflammation in Atomic Bomb Survivors
Relationship Between Radiation Dose and Markers of Insulin Resistance and Inflammation in Atomic Bomb Survivors Open
Context In recent studies of childhood cancer survivors, diabetes has been considered a late effect associated with high therapeutic doses of radiation therapy. Our recent study of atomic bomb (A-bomb) survivors also suggested an associati…
View article: Magnetic resonance elastography for the prediction of hepatocellular carcinoma in chronic hepatitis B
Magnetic resonance elastography for the prediction of hepatocellular carcinoma in chronic hepatitis B Open
Background and Aim Magnetic resonance elastography (MRE) is used for the evaluation of liver fibrosis; however, it remains unclear whether MRE‐based liver stiffness is associated with hepatocellular carcinoma (HCC) development, particularl…
View article: Efficacy and safety of endoscopic ultrasound‐guided gallbladder drainage without dilation by using a 0.035‐inch stiff guidewire
Efficacy and safety of endoscopic ultrasound‐guided gallbladder drainage without dilation by using a 0.035‐inch stiff guidewire Open
Endoscopic ultrasound‐guided gallbladder drainage for patients with cholecystitis and high surgical risk is commonly performed by dilating the fistula before inserting the delivery sheath; however, this carries an increased risk of periton…
View article: Detailed Clinical Characteristics, Interventions, and Long-Term Outcomes of Patients With Gastric Cancer Who Received the Best Supportive Care Without Any Anticancer Treatment
Detailed Clinical Characteristics, Interventions, and Long-Term Outcomes of Patients With Gastric Cancer Who Received the Best Supportive Care Without Any Anticancer Treatment Open
Background: Due to the lack of studies, the long-term prognoses of unfit patients with gastric cancer (GC) who did not receive any aggressive cancer treatment (best supportive care [BSC] cases) remain unclear, especially for those with pot…
View article: Neurocognitive Function in Aged Survivors Exposed to Atomic Bomb Radiation In Utero: The Radiation Effects Research Foundation Adult Health Study
Neurocognitive Function in Aged Survivors Exposed to Atomic Bomb Radiation In Utero: The Radiation Effects Research Foundation Adult Health Study Open
Although some adverse effects on neurocognitive function have been reported in children and adolescents irradiated prenatally during the atomic bombings and the Chernobyl nuclear accident, little information is available for effects on the…
View article: Switching from entecavir to tenofovir alafenamide for maintaining complete virological response in chronic hepatitis B
Switching from entecavir to tenofovir alafenamide for maintaining complete virological response in chronic hepatitis B Open
Background and Aim Hepatocellular carcinoma development can be decreased by achieving and maintaining complete virological response (CVR) in chronic hepatitis B. However, it is unclear whether switching from entecavir (ETV) to tenofovir al…
View article: Pemigatinib treatment for intrahepatic cholangiocarcinoma with <scp>FGFR2</scp> fusion detected by a liquid comprehensive genomic profiling test
Pemigatinib treatment for intrahepatic cholangiocarcinoma with <span>FGFR2</span> fusion detected by a liquid comprehensive genomic profiling test Open
Key Clinical Message The liquid CGP was useful for detecting FGFR2 fusion and the patient experienced typical side effects (nail disorders, hyperphosphatemia, and taste disorders) of pemigatinib that required treatment.
View article: Risk of cardiovascular disease in lean patients with nonalcoholic fatty liver disease
Risk of cardiovascular disease in lean patients with nonalcoholic fatty liver disease Open
View article: Pemigatinib treatment for intrahepatic cholangiocarcinoma with FGFR2 fusion detected by a liquid comprehensive genomic profiling test
Pemigatinib treatment for intrahepatic cholangiocarcinoma with FGFR2 fusion detected by a liquid comprehensive genomic profiling test Open
Pemigatinib treatment for intrahepatic cholangiocarcinoma with FGFR2 fusion detected by a liquid comprehensive genomic profiling testShun Ishido¹*, Nobuharu Tamaki¹*, Kento Inada¹, Jun Itakura¹, Yuka Takahashi¹, Naoki Uchihara¹, Keito Suzu…
View article: The Effect of Prostate-Specific Antigen (PSA) Test on Radiation Risk Estimate for Prostate Cancer Incidence among Atomic-Bomb Survivors
The Effect of Prostate-Specific Antigen (PSA) Test on Radiation Risk Estimate for Prostate Cancer Incidence among Atomic-Bomb Survivors Open
Following our previous report on the radiation dose-response for prostate cancer incidence rates in the Life Span Study (LSS) cohort of atomic bomb survivors, we reevaluated the radiation-related risk adjusting for differences in baseline …
View article: Two Cases of Immune-Related ACTH Deficiency after the Initiation of Atezolizumab plus Bevacizumab for Multiple Hepatocellular Carcinoma
Two Cases of Immune-Related ACTH Deficiency after the Initiation of Atezolizumab plus Bevacizumab for Multiple Hepatocellular Carcinoma Open
Background: There have been a few case reports of immune-related Adrenocorticotropic Hormone (ACTH) deficiency in cases of atezolizumab plus bevacizumab therapy for unresectable HCC.Our report aims to enhance comprehension of immune-relate…
View article: Risk of cardiovascular disease in lean patients with nonalcoholic fatty liver disease
Risk of cardiovascular disease in lean patients with nonalcoholic fatty liver disease Open
Background: Patients with nonalcoholic fatty liver disease (NAFLD) are highly at risk for cardiovascular disease (CVD). However, the risk of developing CVD in patients with lean NAFLD is not yet fully understood. Therefore, this study aime…
View article: Clinical Utility of Comprehensive Genomic Profiling in Patients with Unresectable Hepatocellular Carcinoma
Clinical Utility of Comprehensive Genomic Profiling in Patients with Unresectable Hepatocellular Carcinoma Open
This study aimed to investigate the clinical usefulness of comprehensive genomic profiling (CGP) in patients with unresectable hepatocellular carcinoma who received multiple systemic therapies in real-world practice. In this study, all nin…
View article: Atypical Pseudo-Meigs' Syndrome without Pleural Effusion Due to Ovarian Metastasis from Sigmoid Colon Cancer
Atypical Pseudo-Meigs' Syndrome without Pleural Effusion Due to Ovarian Metastasis from Sigmoid Colon Cancer Open
We herein report a case of atypical pseudo-Meigs' syndrome without pleural effusion. A 46-year-old woman was diagnosed with an ovarian tumor and sigmoid colon cancer with massive ascites. She underwent surgical resection of the sigmoid col…
View article: Clinical Usefulness of Monitoring Muscle Volume during Atezolizumab Plus Bevacizumab Therapy in Patients with Unresectable Hepatocellular Carcinoma
Clinical Usefulness of Monitoring Muscle Volume during Atezolizumab Plus Bevacizumab Therapy in Patients with Unresectable Hepatocellular Carcinoma Open
Background: Sarcopenia is associated with overall survival in patients with hepatocellular carcinoma (HCC). However, it is not known whether muscle volume is associated with clinical outcomes during combination therapy with immune checkpoi…
View article: Incidence of Diabetes in the Atomic Bomb Survivors: 1969-2015
Incidence of Diabetes in the Atomic Bomb Survivors: 1969-2015 Open
Context Recent epidemiological studies have shown increased risk of diabetes among childhood cancer survivors who received high therapeutic doses of radiation, particularly to the total body or to the abdomen. However, the effect of low-to…
View article: Prediction of Lifetime Risk of Cardiovascular Disease Deaths Stratified by Sex in the Japanese Population
Prediction of Lifetime Risk of Cardiovascular Disease Deaths Stratified by Sex in the Japanese Population Open
Background Lifetime risk is an informative estimate for driving lifestyle and behavioral changes especially for young adults. The impact of composite risk factors for cardiovascular disease on lifetime risk stratified by sex has not been i…
View article: Risk Classification for Metabolic Syndrome and the Incidence of Cardiovascular Disease in Japan With Low Prevalence of Obesity: A Pooled Analysis of 10 Prospective Cohort Studies
Risk Classification for Metabolic Syndrome and the Incidence of Cardiovascular Disease in Japan With Low Prevalence of Obesity: A Pooled Analysis of 10 Prospective Cohort Studies Open
Background It is uncertain whether risk classification under the nationwide program on screening and lifestyle modification for metabolic syndrome captures well high‐risk individuals who could benefit from lifestyle interventions. We exami…
View article: Association of Thyroid Dysfunction With Cognitive Function
Association of Thyroid Dysfunction With Cognitive Function Open
In this individual participant data analysis of more than 74 000 adults, subclinical hypothyroidism and hyperthyroidism were not associated with cognitive function, cognitive decline, or incident dementia. No rigorous conclusions can be dr…
View article: Evaluation of a New Home Patient Services Practicum for Community Pharmacy Students in Japan
Evaluation of a New Home Patient Services Practicum for Community Pharmacy Students in Japan Open
This study aimed to evaluate the usefulness of the practicum as well as assess the knowledge, skills, and various specific realizations that the students gained from it. A total of 244 students role-played a scenario in which a pharmacist …
View article: Yamada et al. Respond to “Radiation and Reproductive Health”
Yamada et al. Respond to “Radiation and Reproductive Health” Open
View article: Congenital Malformations and Perinatal Deaths Among the Children of Atomic Bomb Survivors: A Reappraisal
Congenital Malformations and Perinatal Deaths Among the Children of Atomic Bomb Survivors: A Reappraisal Open
From 1948 to 1954, the Atomic Bomb Casualty Commission conducted a study of pregnancy outcomes among births to atomic bomb survivors (Hiroshima and Nagasaki, Japan) who had received radiation doses ranging from 0 Gy to near-lethal levels. …
View article: Radiation effects on atherosclerosis in atomic bomb survivors: a cross‐sectional study using structural equation modeling
Radiation effects on atherosclerosis in atomic bomb survivors: a cross‐sectional study using structural equation modeling Open
View article: Successful pembrolizumab treatment of microsatellite instability‐high intrahepatic cholangiocarcinoma: A case report
Successful pembrolizumab treatment of microsatellite instability‐high intrahepatic cholangiocarcinoma: A case report Open
Key Clinical Message The tumor reduction effect of pembrolizumab is extremely high compared to standard chemotherapy and might show prolonged survival. Therefore, the MSI status should be examined in patients with cholangiocarcinoma.
View article: Successful pembrolizumab treatment of microsatellite instability-high intrahepatic cholangiocarcinoma: A case report
Successful pembrolizumab treatment of microsatellite instability-high intrahepatic cholangiocarcinoma: A case report Open
Pembrolizumab is considered to be an effective therapy for patients with microsatellite instability (MSI)-high cancer. Here, we report a case of MSI-high cholangiocarcinoma effectively treated with pembrolizumab. MSI status should be activ…
View article: Longitudinal changes in red blood cell distribution width decades after radiation exposure in atomic‐bomb survivors
Longitudinal changes in red blood cell distribution width decades after radiation exposure in atomic‐bomb survivors Open
Summary Red blood cell distribution width (RDW), which generally increases with age, is a risk marker for morbidity and mortality in various diseases. We investigated the association between elevated RDW and prior radiation exposure by exa…
View article: Cognitive effects of low dose of ionizing radiation – Lessons learned and research gaps from epidemiological and biological studies
Cognitive effects of low dose of ionizing radiation – Lessons learned and research gaps from epidemiological and biological studies Open
The last decades have seen increased concern about the possible effects of low to moderate doses of ionizing radiation (IR) exposure on cognitive function. An interdisciplinary group of experts (biologists, epidemiologists, dosimetrists an…
View article: Cognitive Function Among Elderly Survivors Prenatally Exposed to Atomic Bombings
Cognitive Function Among Elderly Survivors Prenatally Exposed to Atomic Bombings Open
We found no significant radiation effect on cognitive function among 65- to 70-year-old subjects who were prenatally exposed to the bombings and did not have marked childhood cognitive function deterioration. The limitations of this study …