Michiya Natori
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View article: Disruption of Tight Junctions in Intestinal Epithelial Cells by Toxic Advanced Glycation End-Products
Disruption of Tight Junctions in Intestinal Epithelial Cells by Toxic Advanced Glycation End-Products Open
Intestinal epithelial cells (IECs) play a crucial role in forming a protective barrier and regulating the absorption of substances passing through the small intestine. Disrupting the epithelial barrier function can result in intestinal dis…
View article: Recent Utilization of Pediatric Extrapolation and Modeling and Simulation Approaches in Pediatric Drug Development in Japan
Recent Utilization of Pediatric Extrapolation and Modeling and Simulation Approaches in Pediatric Drug Development in Japan Open
In Japan, the percentage of approved drugs with pediatric indications increased to 30% in 2010‐2015, but no further increase was observed through 2020. The Ministry of Health, Labor, and Welfare in Japan presented draft future directions t…
View article: Estradiol accelerates liver regeneration through estrogen receptor α
Estradiol accelerates liver regeneration through estrogen receptor α Open
Yoji Tsugawa,1 Michiya Natori,2 Hiroshi Handa,3 Takeshi Imai11Department of Aging Intervention, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8511, Japan; 2Department of Obstetrics and Gynecology, Tokyo Medical University,…
View article: <p>Estradiol accelerates liver regeneration through estrogen receptor α</p>
Estradiol accelerates liver regeneration through estrogen receptor α Open
Background: We previously demonstrated that liver resection triggers estradiol production, which, in turn, induces the proliferation of hepatocytes to promote liver regeneration in mice. In this study, we demonstrated estradiol-induced est…